Browse our anti-serglycin (SRGN) Antibodies

Full name:
anti-serglycin Antibodies (SRGN)
On www.antibodies-online.com are 45 serglycin (SRGN) Antibodies from 16 different suppliers available. Additionally we are shipping serglycin Kits (14) and serglycin Proteins (11) and many more products for this protein. A total of 76 serglycin products are currently listed.
Synonyms:
Pgsg, PPG, Prg, Prg1, Sgc

Most Popular Reactivities for anti-serglycin (SRGN) Antibodies

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anti-Rat (Rattus) Antibodies:

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Top referenced anti-serglycin Antibodies

  1. Human Polyclonal SRGN Primary Antibody for EIA, FACS - ABIN954731 : Ma, Rudd, Edner, Gavhed, Ramme, Fadeel, Nordenskjöld, Henter, Zheng: Sequence analysis of the SRGN, AP3B1, ARF6, and SH2D1A genes in familial hemophagocytic lymphohistiocytosis. in Pediatric blood & cancer 2008 (PubMed)
    Show all 5 references for 954731

  2. Human Polyclonal SRGN Primary Antibody for IHC, IHC (p) - ABIN4355974 : Chang, Chan, Braun, Green, OBrien, Chait, Day, Wight: Monocyte-to-macrophage differentiation: synthesis and secretion of a complex extracellular matrix. in The Journal of biological chemistry 2012 (PubMed)
    Show all 4 references for 4355974

  3. Human Monoclonal SRGN Primary Antibody for ELISA, WB - ABIN519156 : Li, Ong, Cao, Xiang, Shao, Ooi, Peng, Lu, Zhang, Petillo, Qin, Bao, Zheng, Chia, Iyer, Kang, Zeng, Soo, Trent, Teh, Qian: Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis. in Cancer research 2011 (PubMed)
    Show all 3 references for 519156

More Antibodies against serglycin Interaction Partners

Human serglycin (SRGN) interaction partners

  1. SRGN secreted by tumor cells and stromal components in the TME promotes malignant phenotypes through interacting with tumor cell receptor CD44 (show CD44 Antibodies)

  2. Extracellular spce serglycin upregulated CD44 (show CD44 Antibodies) receptor expression to maintain nasopharyngeal carcinoma stemness by interacting with CD44 (show CD44 Antibodies) and activating the MAPK (show MAPK1 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway.

  3. SRGN expression is significantly upregulated in human masticatory mucosa during wound healing

  4. Patients with NPC (show NPC1 Antibodies) with tumors showing strong tumor intensity and low infiltrated percentage of tumor-infiltrated lymphocytes with serglycin may be at high risk for distant metastases.

  5. The elevated levels of serglycin in aggressive cancer and stromal cells may suggest a key role for serglycin in disease progression

  6. These results suggest functions for serglycin in endothelial cells trough interactions with partner molecules, in biological processes with relevance for diabetic complications, cardiovascular disease and cancer development.

  7. These results suggest that different signaling pathways are involved in regulating secretion of serglycin and partner molecules in activated endothelial cells.

  8. The reduced expression of SRGN was accompanied by elevated levels of E-cadherin (show CDH1 Antibodies).

  9. These studies provide direct evidence for a critical role for serglycin in MM pathogenesis and show that targeting serglycin may provide a novel therapeutic approach for MM.

  10. These results suggest that human epicardial adipose tissue (EAT) has strong inflammatory properties in patients with coronary artery disease and provide novel evidence that serglycin is an adipocytokine highly expressed in EAT.

Mouse (Murine) serglycin (SRGN) interaction partners

  1. Data suggest that serglycin proteoglycans play a role in extravasation as well as colonization and growth of metastatic cells.

  2. serglycin deficient mice exhibited elevated concentrations of serum LDL after feeding high-fat diet for 20 weeks.

  3. serglycin plays a critical role in the maturation of dense-core cytotoxic granules in cytotoxic lymphocytes and the trafficking and storage of perforin (show PRF1 Antibodies) and granzyme B (show Gzmb Antibodies), whereas granzyme A (show GZMA Antibodies) is unaffected

  4. Wild-type mast cells efficiently degraded exogenous or endogenously produced IL-13 (show IL13 Antibodies) upon degranulation,whereas serglycin -/- mast cells completely lacked this ability.

  5. Dopamine storage increased during mast cell maturation from bone marrow precursors, and was dependent on the presence of serglycin.

  6. Cells lacking mouse mast cell protease 6 (show TPSB2 Antibodies) exhibited similar defects in apoptosis as observed in serglycin(-/-) cells, indicating that the pro-apoptotic function of serglycin is due to downstream effects of proteases that are complex-bound to serglycin

  7. The PRG-1 (show PTGR1 Antibodies) transcription is initiated at multiple transcription start site and no influence on expression in vivo by Nex1 (show NEUROD6 Antibodies) deficiency.

  8. serglycin proteoglycan as a novel player in mast cell apoptosis.

  9. serglycin proteoglycan is dispensable for normal secretion and activity of mast cell proteases in response to peritoneal infection with T. gondii.

  10. SG proteoglycan (show Vcan Antibodies) has a key role in mast cell function

serglycin (SRGN) Antigen Profile

Antigen Summary

This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene.

Alternative names and synonyms associated with serglycin (SRGN)

  • serglycin (SRGN) antibody
  • serglycin (Srgn) antibody
  • Pgsg antibody
  • PPG antibody
  • Prg antibody
  • Prg1 antibody
  • Sgc antibody

Protein level used designations for anti-serglycin (SRGN) Antibodies

hematopoetic proteoglycan core peptide , hematopoetic proteoglycan core protein , hematopoietic proteoglycan core protein , p.PG , platelet proteoglycan core protein , proteoglycan 1, secretory granule , proteoglycan protein core for mast cell secretory granule , secretory granule proteoglycan core peptide , secretory granule proteoglycan core protein , serglycin proteoglycan , gp600 , mastocytoma proteoglycan core protein , proteoglycan, secretory granule , PG19 core protein , chondroitin sulfate proteoglycan core protein , cytolytic granule proteoglycan core protein , proteoglycan 10K core protein , proteoglycan peptide core protein

GENE ID SPECIES
5552 Homo sapiens
19073 Mus musculus
56782 Rattus norvegicus
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