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anti-Human SUN1 Antibodies:
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Human Polyclonal SUN1 Primary Antibody for ICC, IF - ABIN4356964
Ramachandran, Pucadyil, Liu, Acharya, Leonard, Lukiyanchuk, Schmid: Membrane insertion of the pleckstrin homology domain variable loop 1 is critical for dynamin-catalyzed vesicle scission. in Molecular biology of the cell 2009
Show all 8 references for ABIN4356964
Human Polyclonal SUN1 Primary Antibody for ICC, IF - ABIN4356962
Chaumet, Wright, Seet, Tham, Gounko, Bard: Nuclear envelope-associated endosomes deliver surface proteins to the nucleus. in Nature communications 2015
Dog (Canine) Polyclonal SUN1 Primary Antibody for IHC, WB - ABIN2783971
Chi, Haller, Peloponese, Jeang: Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes. in The Journal of biological chemistry 2007
Human Polyclonal SUN1 Primary Antibody for WB - ABIN525108
Jung, Nobumori, Goulbourne, Tu, Lee, Tatar, Wu, Yoshinaga, de Jong, Coffinier, Fong, Young: Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration. in Proceedings of the National Academy of Sciences of the United States of America 2013
Human Monoclonal SUN1 Primary Antibody for ICC, IF - ABIN1042680
Hodzic, Yeater, Bengtsson, Otto, Stahl: Sun2 is a novel mammalian inner nuclear membrane protein. in The Journal of biological chemistry 2004
Coiled-coil domains of SUN-1 are required for oligomerization and retention of the protein in the nuclear envelope, especially at later stages of female gametogenesis.
POT-1 (show POT1 Antibodies) has a role in anchoring telomeres through SUN-1 at the nuclear periphery.
This suggests that SUN-1 phosphorylation is critical to delaying meiosis in response to perturbed synapsis. SUN-1 may be an integral part of a checkpoint system to monitor establishment of the obligate crossover
The dynamics of matefin/SUN-1 aggregates remained unchanged throughout leptonene/zygotene, despite the progression of pairing.
Data show that ZYG-12 is immobile at the outer nuclear membrane and that SUN-1 is sufficient to localize ZYG-12 in cells.
Data suggest that the properties of the nuclear envelope are altered during the time window when homologs are sorted and Matefin/SUN-1 aggregates form, thereby controling the movement, homologous pairing and interhomolog recombination of chromosomes.
wndchrm revealed a consistent negative correlation between SUN1 expression and the size of nucleoli in human breast cancer tissues.
Nuclear envelope associated endosome-mediated transfer depends on the nuclear envelope proteins SUN1 and SUN2 (show SUN2 Antibodies), as well as the Sec61 (show SEC61A1 Antibodies) translocon complex.
SUN1 plays a role in hnRNP (show HNRNPC Antibodies)-involved mRNA export.
An important role for SUN1 and SUN2 (show SUN2 Antibodies) in muscle disease pathogenesis.
these data support a model whereby mitotic phosphorylation of SUN1 disrupts interactions with nucleoplasmic binding partners, promoting disassembly of the nuclear lamina and, potentially, its chromatin interactions
The Caenorhabditis elegans lamin, LMN-1, is required for nuclear migration and interacts with the nucleoplasmic domain of the SUN protein UNC-84.
Results highlight the interactions at the nuclear envelope where mutations in the EMD (show EMD Antibodies) and TMPO (show TMPO Antibodies) gene in combination with mutations in SUN1 have an impact on several components of the network.
Farnesylation of progerin enhances its interaction with SUN1 and reduces SUN1 mobility.
Codepletion of SUN1/2 slows cell proliferation and results in an accumulation of morphologically defective and disoriented mitotic spindles.
Reduction of SUN1 overaccumulation in LMNA mutant fibroblasts and in cells derived from (show LMNA Antibodies) HGPS patients corrected nuclear defects and cellular senescence.
Results provide evidence that SUN1 and KASH5 are essential factors in the regulation of meiotic resumption and spindle formation.
A cell-type-specific role for Sun1 and Sun2 (show SUN2 Antibodies) in nucleokinesis during cerebellar development, is reported.
ablation of the kinase CDK2 alters the nuclear envelope in mouse spermatocytes, and that the proteins SUN1, KASH5 (also known as CCDC155) and lamin C2 show an abnormal cap-like distribution facing the centrosome.
our results clearly indicate that SUN1 and SUN2 (show SUN2 Antibodies), at least partially, fulfill redundant meiotic functions
Sun1, a component of LINC complexes, but not A-type lamins, which interact with LINC complexes at the nuclear envelope, participate in cone nuclei positioning.
Sun1 has a role in DNA damage response.
It was shown KASH5 possesses hitherto unknown KASH-related sequences that directly interacted with SUN1 and mediated telomere localization. KASH5 interacted with the microtubule-associated dynein- dynactin (show DCTN1 Antibodies) complex.
These findings implicate Sun1 protein accumulation as a common pathogenic event in Lmna (show LMNA Antibodies)(-/-), LmnaDelta9 mice, models for Emery-Dreifuss muscular dystrophy and Hutchinson-Gilford progeria disorders.
Syne-2 (show SYNE2 Antibodies), SUN1 and SUN2 (show SUN2 Antibodies) play critical roles during interkinetic nuclear migration and photoreceptor cell migration in the mouse retina development.
perturbations in lamin A (show LMNA Antibodies)-SUN1 and SUN2 (show SUN2 Antibodies) protein interactions may underlie the opposing effects of EDMD (show EMD Antibodies) and HGPS (show LMNA Antibodies) mutations on nuclear and cellular mechanics
This gene is a member of the unc-84 homolog family and encodes a nuclear nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Alternatively spliced transcript variants have been described.
SUN domain-containing protein 1
, Sad1 unc-84 domain protein 1
, protein unc-84 homolog A
, sad1/unc-84 protein-like 1
, unc-84 homolog A