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Tacc3 is required for the proper mitosis of Apc (show APC Proteins)-deficient ISCs (show NFS1 Proteins), and its disruption significantly attenuated the expansion of the crypt domain. In vivo analysis of corresponding mutant mice demonstrated that Tacc3 disruption led to a significant decrease in tumor number and prolonged survival.
Aurora-A kinase does not regulate TACC3-chTOG complex formation, indicating that Aurora-A solely functions as a recruitment factor for the TACC3-chTOG complex to centrosomes and proximal mitotic spindles.
The TACC3 and clathrin were interdependent for spindle recruitment, having to interact in order for either to be recruited to the spindle.
DOCK7 interaction with TACC3 controls interkinetic nuclear migration and the genesis of neurons from radial glial progenitor cells during cortical development
results show that Tacc3 is a vulnerable component of the spindle assembly in lymphoma cells and is a promising cancer chemotherapy target
Tacc3 is a negative regulator of the Notch (show NOTCH1 Proteins) signaling pathway.
role in hematopoietic stem cell function and interface with p53 (show TP53 Proteins)-regulated apoptosis
the alpha-helix of FOG (show APAF1 Proteins)-ZF3 recognizes a C-terminal portion of the TACC3 coiled-coil.
in addition to spindle assembly, Tacc3 has critical roles in chromosome separation and cytokinesis, and is essential for the mitosis of sclerotome mesenchymal cells during axial formation in mammals.
The combination treatment of SNIPER(TACC3) and bortezomib exhibited a synergistic anticancer activity in several cancer cell lines.
Study provides evidence of the significant oncogenic potential of the FGFR3 (show FGFR3 Proteins)-TACC3 fusion protein. The presence of the TACC coiled-coil domain leads to increased and altered levels of FGFR3 (show FGFR3 Proteins) activation, fusion protein phosphorylation, downstream signaling, cellular transformation, proliferation, and viability.
Taken together, these findings uncover a supportive role for TACC3 in PCa (show FLVCR1 Proteins) metastasis, which is mediated by the activation of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway, suggesting that TACC3 may serve as a prognostic marker in patients with metastatic PCa (show FLVCR1 Proteins).
our observations identify TACC3 as an oncogene (show RAB1A Proteins) of tumor malignancy, as well as a prognostic and motoring biomarker for glioma patients.
The results showed that the expression of TACC3 was downregulated in preeclamptic placentas.
TACC3 overexpression was associated with clinicopathological features of aggressiveness, increased EMT (show ITK Proteins)-related protein expression, and poor survival, suggesting a potential role for TACC3 as a prognostic biomarker and therapeutic target in HCC (show FAM126A Proteins)
Results showed that high level of TACC3 expression was correlated with advanced clinicopathological classifications, and poor prognosis in non-small cell lung cancer patients indicating that TACC3 is a potential prognostic marker.
TACC3 is enriched in hepatocellular carcinoma and down-regulation inhibits the proliferation, clonogenicity, and cancer stem cell-like phenotype of HCC (show FAM126A Proteins) cells
The measurement of TACC3 protein expression may be beneficial for predicting clinical outcomes for gastric cancer patients
TACC3 depletion in human cell lines causes shorter mitotic spindles. co-immunoprecipitation experiments showed reduced binding between TACC3-F543A and Aurora-A (show AURKA Proteins).
TACC1 (show TACC1 Proteins) and TACC3 are each required for maintaining normal microtubule growth speed in Xenopus
XTACC3 can induce the recruitment of larger amounts of XMAP215 by increasing its local concentration, thereby promoting efficient microtubule elongation during mitosis
TACC3 promotes axon outgrowth and regulates microtubule dynamics in multiple embryonic cell types.
Results suggest that phosphorylation of maskin by Aurora-A (show AURKA Proteins) prevents meiosis II proteins from being produced during meiosis I.
Maskin functions in mitotic spindle assembly.
Maskin activity and localization is controlled by differential phosphorylation
Maskin phosphorylation-dephosphorylation also oscillates with the cell cycle and is controlled by the kinase CDK1 and the phosphatase calcineurin
Maskin mRNA is translationally regulated by at least two repressor elements and an activation element.
This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells.
, Arnt interacting protein
, transforming acidic coiled-coil-containing protein 3
, transforming acidic coiled coil 3
, CPEB-associated factor Maskin
, cytoplasmic polyadenylation element-binding protein-associated factor Maskin