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the TAF2-TAF8-TAF10 complex demonstrates that there is a stepwise assembly pathway of nuclear holo-TFIID, regulated by nuclear import of preformed cytoplasmic submodules
This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
, TBP-associated factor
, TBP-associated factor 8
, transcription initiation factor TFIID subunit 8
, TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 45/50kDa
, TBP-associated factor 43 kDa
, TBP-associated factor TAFII43
, TBP-associated factor, RNA polymerase II, 43 kD
, protein taube nuss
, taube nuss homolog
, transcription initiation factor TFIID 43 kDa subunit
, taube nuss