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Show all synonyms
Tex14 is an important mediator of kinetochore structure and function and the fidelity of chromosome separation.
TEX14 prevents the completion of cytokinesis by altering the destiny of CEP55 (show CEP55 ELISA Kits) from a nidus for abscission to an integral component of the intercellular bridge.
TEX14, also known as SgK307, contains a variant and probably inactive protein kinase domain and N-terminal ankyrin repeats.
TEX14 is specifically expressed in testis
Data indicate that testis-expressed gene 14 (TEX14) is expressed in germ cells.
RBM44 interacts with itself and TEX14 using yeast two-hybrid, mammalian two-hybrid, and immunoprecipitation.
TEX14 is required for intercellular bridges in vertebrate germ cells, and these studies provide evidence that the intercellular bridge is essential for spermatogenesis and fertility
Despite the absence of embryonic intercellular bridges in the Tex14-null mice, male mice initiate spermatogenesis, and female mice are fertile. But fewer oocytes were present in Tex14-null neonatal ovaries.
Tex14 is expressed throughout spermatogenesis
Tex14 is specifically expressed in testis in a cDNA subtraction screen
The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.
inactive serine/threonine-protein kinase TEX14
, testis expressed gene 14
, testis-expressed protein 14
, testis-expressed sequence 14 protein
, testis expressed 14
, testis expressed sequence 14
, testis-expressed protein 14-like
, cancer/testis antigen 113
, protein kinase-like protein SgK307
, sugen kinase 307