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anti-Human TOPORS Antibodies:
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Human Monoclonal TOPORS Primary Antibody for IF, IHC (p) - ABIN564418
Hackbarth, Galvez-Peralta, Dai, Loegering, Peterson, Meng, Karnitz, Kaufmann: Mitotic phosphorylation stimulates DNA relaxation activity of human topoisomerase I. in The Journal of biological chemistry 2008
dtopors plays a structural role in spermatocyte lamina that is critical for multiple aspects of meiotic chromosome transmission
Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein
Data suggest a mechanism for the inhibitory effects of Sdc-1 (show SDC1 Antibodies) on cell growth that involves the interaction between the cytoplasmic domain of Sdc-1 (show SDC1 Antibodies) and the SUMO-1 (show SUMO1 Antibodies) E3 ligase, Topors.
These results indicate a unique role for Topors in the maintenance of genomic stability and pericentric heterochromatin, as well as in cellular sensitivity to histone deacetylase (show HDAC1 Antibodies) inhibitors.
NKX3.1 (show NKX3-1 Antibodies) can be ubiquitinated by TOPORS in vitro and in vivo, and overexpression of TOPORS leads to NKX3.1 (show NKX3-1 Antibodies) proteasomal degradation in prostate cancer cells
P26s4 (show PSMC1 Antibodies) Associates with the C-Terminal Region of TOPORS.
Data suggest that TOPORS plays key role in turnover of H2AX (show H2AFX Antibodies) (H2A histone family, member X protein) depending on the type of oxidative stress/DNA damage; TOPORS may act as an E3 ubiquitin ligase (show MUL1 Antibodies) for histones.
Disturbed flow induces peroxynitrite production and binding to the E3 SUMO (small ubiquitin-like modifier (show SUMO1 Antibodies)) ligase PIASy (show PIAS4 Antibodies) (protein inhibitor of activated STATy).
In photoreceptors, TOPORS localizes primarily to the basal bodies of connecting cilium and in the centrosomes.
Polo-like kinase 1 (Plk1 (show PLK1 Antibodies))-associated phosphorylation of Topors at S718 is essential for nocodazole-induced degradation of Topors.
We present a novel mutation in the TOPORS gene co-segregating with a distinct phenotype of adPRD in a large Norwegian family.
Topors, a p53 (show TP53 Antibodies) and topoisomerase I (show TOP1 Antibodies) binding protein, interacts with the adeno (show ADORA2A Antibodies)-associated virus (AAV-2) Rep78/68 proteins and enhances AAV-2 gene expression
topors localizes in punctate nuclear regions associated with PML (show PML Antibodies) protein nuclear bodies.
Multiple SUMO-1 (show SUMO1 Antibodies) modified forms of Topors could be detected after cotransfection of exogenous SUMO-1 (show SUMO1 Antibodies) and Topors induced the colocalization of a YFP tagged SUMO-1 (show SUMO1 Antibodies) protein in a speckled pattern in the nucleus.
topors functions as a negative regulator of cell growth, and possibly as a tumor suppressor
This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus.
, topoisomerase I-interacting protein
, E3 ubiquitin-protein ligase Topors
, topoisomerase I binding, arginine/serine-rich
, E3 ubiquitin-protein ligase Topors-like
, e3 ubiquitin-protein ligase Topors-like
, SUMO1-protein E3 ligase Topors
, p53-binding protein 3
, topoisomerase 1-binding RING finger
, topoisomerase I-binding RING finger protein
, topoisomerase I-binding arginine/serine-rich protein
, tumor suppressor p53-binding protein 3