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|Application / Reactivity||Mouse (Murine)||Human||Rat (Rattus)||Monkey|
|Western Blotting (WB)||185 Antibodies||377 Antibodies||129 Antibodies||9 Antibodies|
|Proximity Ligation Assay (PLA)||2 Antibodies|
|Immunostaining (ISt)||1 Antibodies|
|Immunoprecipitation (IP)||35 Antibodies||35 Antibodies||3 Antibodies||14 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||63 Antibodies||34 Antibodies||23 Antibodies|
|Immunohistochemistry (IHC)||272 Antibodies||142 Antibodies||9 Antibodies||120 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||2 Antibodies||3 Antibodies|
|Antigen||BCL2-Associated Agonist of Cell Death (BAD) Antibodies|
|Reactivity||Human, Monkey, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This BAD antibody is un-conjugated Alternatives|
Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
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Product Details anti-BAD AntibodyTarget Details BAD Application Details Handling Images
|Specificity||The antibody detects the 22 kDa Bad protein and it does not cross-react with related family members.|
|Cross-Reactivity (Details)||Does not cross-react with related family members.|
|Immunogen||Synthetic peptide surrounding amino acid 115 of mouse Bad|
Target Details BADProduct Details anti-BAD Antibody Application Details Handling Images back to top
|Alternative Name||Bad (BAD Antibody Abstract)|
The Bcl-2 (B-cell leukemia/lymphoma 2) family proteins function to either inhibit (Bcl-2 and Bcl-XL) or promote (Bax and Bad) apoptosis. Similar to other family member, Bad also exhibits sequence homology to Bcl-2. Bad can selectively dimerize with Bcl-xL and Bcl-2, but not with Bax, Bcl-xs, Mcl-1, or itself. In mammalian cells, Bad binds more strongly to Bcl-xL than Bcl-2. This may explain why Bad reverse the death repressor activity of Bcl-xL, but not that of Bcl-2
Synonyms: BBC6, BCL2L8, Bcl-2-binding component 6, Bcl-2-like 8 protein
|Research Area||Cancer, Apoptosis/Necrosis|
|Pathways||MAPK Signaling, PI3K-Akt Signaling, RTK Signaling, Apoptosis, Fc-epsilon Receptor Signaling Pathway|
Application DetailsProduct Details anti-BAD Antibody Target Details BAD Handling Images back to top
Western blot analysis (1-2 μg/mL), Immunoprecipitation (4-8 μg/mL), and Immunohistochemistry (20-40 μg/mL).
However, the optimal conditions should be determined individually.
Country of Animal Origin: China
|Restrictions||For Research Use only|
HandlingProduct Details anti-BAD Antibody Target Details BAD Application Details Images back to top
|Buffer||100 μg (0.5 mg/mL) antigen affinity purified rabbit anti-Bad polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50 % glycerol, 1 % BSA, 0.02 % thimerosal.|
|Precaution of Use||This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
|Storage Comment||For long-term storage, aliquot and freeze at -70 °C.|
|Expiry Date||12 months|