Browse our BCL2 Proteins (BCL2)

Full name:
B-Cell CLL/lymphoma 2 Proteins (BCL2)
On www.antibodies-online.com are 28 B-Cell CLL/lymphoma 2 (BCL2) Proteins from 12 different suppliers available. Additionally we are shipping BCL2 Antibodies (1098) and BCL2 Kits (91) and many more products for this protein. A total of 1250 BCL2 products are currently listed.
Synonyms:
AW986256, BCL-2, Bcl2, C430015F12Rik, D630044D05Rik, D830018M01Rik, PPP1R50
list all proteins Gene Name GeneID UniProt
BCL2 596 P10415
Rat BCL2 BCL2 24224 P49950
BCL2 12043 P10417

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BCL2 Proteins (BCL2) by Origin

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Top referenced BCL2 Proteins

  1. Human BCL2 Protein expressed in Escherichia coli (E. coli) - ABIN667734 : Fernandez-Sarabia, Bischoff: Bcl-2 associates with the ras-related protein R-ras p23. in Nature 1993 (PubMed)
    Show all 2 references for 667734

  2. Human BCL2 Protein expressed in Wheat germ - ABIN1346542 : Su, Guo, Qi: Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy. in Biochimica et biophysica acta 2014 (PubMed)

More Proteins for BCL2 Interaction Partners

Mouse (Murine) B-Cell CLL/lymphoma 2 (BCL2) interaction partners

  1. This study provides evidence from transgenic mouse models that Crebbp (show CREBBP Proteins) deletion results in deficits in B-cell development and can cooperate with Bcl2 overexpression to promote B-cell lymphoma.

  2. an essential role for the binding of BCL2 to BIM (show BCL2L11 Proteins) in the survival of noncycling NK cells.

  3. LIGHT signalling pathway combined with IFN-gamma (show IFNG Proteins) induces beta cells apoptosis via an NF-kappaB (show NFKB1 Proteins)/Bcl2-dependent mitochondrial pathway.

  4. Bcl-2 was highly expressed in tubulointerstitial infiltrates in (NZB x NZW)F1 (NZB/NZW) lupus-prone mice.

  5. The abnormal expression of epidermal cytokeratins suggests that Ha-Ras and Bcl-2 suppress the terminal differentiation and sustain the stem cell-like features in epidermal keratinocytes

  6. the augmentation of endogenous MTA1 (show MTA1 Proteins) expression during neuronal ischemic injury acts additionally to an endocrinous cascade orchestrating intimate interactions between ERalpha (show ESR1 Proteins) and BCL2 pathways.

  7. Interestingly, SKPs showed higher protein levels of Bcl-2, Nrf2 (show NFE2L2 Proteins), and HO-1 (show HMOX1 Proteins) than FBs (show FBS Proteins). SKPs exert a beneficial effect on resisting UVB-induced apoptosis, which may be associated with Bcl-2 and Nrf2 (show NFE2L2 Proteins) upregulation.

  8. Bcl-2 is an essential regulator in the survival of doublecortin (show DCX Proteins)-expressing immature neurons.

  9. Results show that the deletion of BCL-2, on its own or in concert with MCL-1 (show MCL1 Proteins), does not affect platelet production or platelet lifespan.

  10. the expression changes observed within the BCL2 family did not depend on STAT3 (show STAT3 Proteins) signalling, in line with its initiating role early in the process, but rather appear to result from relief of repression by STAT5 (show STAT5A Proteins).

Guinea Pig B-Cell CLL/lymphoma 2 (BCL2) interaction partners

  1. bcl-2 and bax (show BAX Proteins) were expressed strongly in denervated guinea-pig facial muscle. [bcl-2; bax (show BAX Proteins)]

Human B-Cell CLL/lymphoma 2 (BCL2) interaction partners

  1. MYC (show MYC Proteins) and BCL2 genetic alterations were profiled using next-generation sequencing and high-resolution single nucleotide polymorphism array in 347 de novo diffuse large B-cell lymphoma cases.

  2. findings suggest that expression of cFLIPL regulates the basal interaction of Bcl-2 with Beclin-1 (show BECN1 Proteins) and substantiates p53 (show TP53 Proteins) dependent ubiquitination of Beclin-1 (show BECN1 Proteins) during autophagic stress to determine the fate of cell death or survival.

  3. Our findings suggest that RACK1 (show GNB2L1 Proteins) promotes proliferation and radioresistance in ESCC cells by activating the AKT (show AKT1 Proteins) pathway, upregulating Bcl-2 expression and downregulating protein levels of Bim (show BCL2L11 Proteins). Our study fills in gaps in the field of RACK1 (show GNB2L1 Proteins) and radiation resistance and may provide new possibilities for improving strategies of radiotherapy in esophageal cancer.

  4. Western blot analysis and quantitative real-time polymerase chain reaction demonstrated reduced expression of pri-miR (show MLXIP Proteins)-211, miR (show MLXIP Proteins)-211, TRPM1 (show TRPM1 Proteins), and MLANA (show MLANA Proteins) levels, after Bcl-2 overexpression, associated with increased expression of well-known miR (show MLXIP Proteins)-211 target genes.

  5. this study elucidated mechanisms of BCL2 overexpression and association of this survival pathway with the BCR (show BCR Proteins)/BTK (show BTK Proteins) signaling pathway in MCL (show FH Proteins), and revealed the role of BTK (show BTK Proteins) in noncanonical NF-kappaB (show NFKB1 Proteins) activation, which also promotes cancer cell survival.

  6. Follicular lymphoma with MYC (show MYC Proteins) and BCL2 translocations, so-called double-hit follicular lymphoma (DH-FL), is part of the spectrum of double-hit high-grade lymphoma.

  7. we propose that the existing controversy reflects the diversity of links between Bcl-2 proteins and Ca(2 (show CA2 Proteins)+) signaling, as certainly not all targets or mechanisms will be operative in every cell type and every condition.

  8. Overview of the pleiotropic functions of BCL2 mediated by its physical binding interaction with other proteins and the various ways BCL2 mutations would affect the normal function of the cell leading to the development of diffuse large B-cell lymphomas (review).

  9. Diffuse large B-cell lymphoma with concurrent high MYC (show MYC Proteins) and BCL2 expression shows evidence of active B-cell receptor signaling

  10. Case Reports: BCL2 gene translocations are a recurrent feature of a distinct subset of histiocytic sarcomas that are associated with follicular lymphoma.

Cow (Bovine) B-Cell CLL/lymphoma 2 (BCL2) interaction partners

  1. Over-expression of STC-1 (show STC1 Proteins) up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 (show CASP3 Proteins) production in the damaged cells. Findings from this study suggest that STC-1 (show STC1 Proteins) plays a protective role in intestinal cells through an antioxidant mechanism.

  2. BoHV-5 replication apparently modulates BCL-2 expression and gene transcription, enhancing production of virus progeny, but does not increase Bax (show BAX Proteins) expression.

  3. G3139, a BCL-2 antisesnse oligonucleotide is a promising candidate for treatment of patients with imatinib-resistant Ph-positive leukemia.

  4. role of vascular endothelial growth factor receptor-1 (show FLT1 Proteins) in Bcl-2 expression

  5. apoptosis-inducing factor (show AIFM1 Proteins) was expressed in luminal alveolar cells and, in concert with a change in bax (show BAX Proteins) protein to bcl-2 protein ratio, might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses

  6. mRNA expression of Bax (show BAX Proteins), Bcl-2, caspase-3 (show CASP3 Proteins) and-7 cannot be used as a reliable apoptosis detection method.

  7. These results propose an additional mechanism whereby resveratrol may exert its cardioprotective effects and suggest a key role for Bcl-2 in the resveratrol anti-apoptotic action, especially in disrupting peroxynitrite-triggered mitochondrial pathway.

Rabbit B-Cell CLL/lymphoma 2 (BCL2) interaction partners

  1. excessive apoptosis does occur in acetabular cartilage with developmental dislocations of the hip, and is positively correlated with high caspase-3 (show CASP3 Proteins) expression as well as low Bcl-2 expression.

  2. These results indicate that RI-PostC can ameliorate myocardial ischemia-reperfusion injury and increase the Bcl-2/Bax ratio through a mechanism involving protein kinase C.

  3. Cinobufagin can remarkably inhibit the proliferation and induce the apoptosis of lens epithelial cells by increasing expression of bax (show BAX Proteins) and decreasing expression of bcl2.

  4. Elevated local temperature of the testis buried in the inguinal pocket increases the apoptosis of spermatogenic cells, and the spermatogenic cell apoptosis is highly correlated with the decreased expression of Bcl-2 and increased expression of Bax (show BAX Proteins).

  5. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 (show TP53 Proteins) and decrease in the antiapoptotic BCl2 proteins.

  6. Isoflurane delayed preconditioning can inhibit the apoptosis of myocardium by up-regulating the expression of Bcl-2 and down-regulating the activation of caspase-3 (show CASP3 Proteins).

  7. Data show that the damaged electron transport chain leads to bcl-2 depletion and MPT opening.

Zebrafish B-Cell CLL/lymphoma 2 (BCL2) interaction partners

  1. These results suggest a role for mitochondrial p53 (show TP53 Proteins) activity in promoting hair cell death due to aminoglycosides, likely upstream of Bax (show BAX Proteins) and Bcl2.

  2. Zebrafish gene expressions of P53 (show TP53 Proteins), Bcl-2, Bax (show BAX Proteins) and caspase-3 (show CASP3 Proteins) were elevated after exposure with microcystin-LR under different ambient temperatures.

  3. Analysis using clinical biopsy specimens revealed autophagy and increased levels of BCL2, S1P1 (show S1PR1 Proteins), and ICAM1 (show ICAM1 Proteins) in human T-lymphoblastic lymphoma compared with T-lymphoblastic leukemia.

  4. Real-time RT-PCR revealed acetaminophen treatment of zebrafish embryos decreased the expression of cox2 and bcl2, but increased p53 (show TP53 Proteins) expression.

  5. Leukemia onset was dramatically accelerated in transgenic fish overexpressing human Notch1 (show NOTCH1 Proteins) and fish bcl-2, indicating synergy between the Notch (show NOTCH1 Proteins) pathway and the bcl2-mediated antiapoptotic pathway.

BCL2 Protein Profile

Protein Summary

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.

Alternative names and synonyms associated with BCL2

  • B-cell CLL/lymphoma 2 (BCL2)
  • B-cell CLL/lymphoma 2 (Bcl2)
  • B-cell CLL/lymphoma 2 (LOC100224888)
  • B cell leukemia/lymphoma 2 (Bcl2)
  • B-cell leukemia/lymphoma 2 (bcl2)
  • B-cell leukemia/lymphoma 2-like (LOC100359045)
  • B-cell CLL/lymphoma 2 protein (BCL-2)
  • AW986256 protein
  • BCL-2 protein
  • Bcl2 protein
  • C430015F12Rik protein
  • D630044D05Rik protein
  • D830018M01Rik protein
  • PPP1R50 protein

Protein level used designations for B-Cell CLL/lymphoma 2 Proteins (BCL2)

apoptosis regulator Bcl-2 , protein phosphatase 1, regulatory subunit 50 , B cell lymphoma 2 associated oncogene , B-cell leukemia/lymphoma 2 , Bcl2-like protein , PCKBCL2 , BCL2B-cell CLL/lymphoma 2 , B-cell lymphoma protein 2 , Bcl2 , zBlp2 , B-cell CLL/lymphoma 2

GENE ID SPECIES
596 Homo sapiens
24224 Rattus norvegicus
396282 Gallus gallus
493934 Felis catus
738409 Pan troglodytes
100224888 Taeniopygia guttata
100049703 Sus scrofa
12043 Mus musculus
570772 Danio rerio
403416 Canis lupus familiaris
281020 Bos taurus
100733337 Cavia porcellus
100359045 Oryctolagus cuniculus
100009447 Oryctolagus cuniculus
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