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Browse our BCL2 Proteins (BCL2)

Full name:
B-Cell CLL/lymphoma 2 Proteins (BCL2)
On www.antibodies-online.com are 22 B-Cell CLL/lymphoma 2 (BCL2) Proteins from 9 different suppliers available. Additionally we are shipping BCL2 Antibodies (1059) and BCL2 Kits (32) and many more products for this protein. A total of 1147 BCL2 products are currently listed.
Synonyms:
AW986256, bcl-2, Bcl2, C430015F12Rik, D630044D05Rik, D830018M01Rik, PPP1R50
list all proteins Gene Name GeneID UniProt
BCL2 12043 P10417
BCL2 596 P10415
Rat BCL2 BCL2 24224 P49950

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BCL2 Proteins (BCL2) by Origin

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Top referenced BCL2 Proteins

  1. Human BCL2 Protein expressed in Escherichia coli (E. coli) - ABIN667734 : Fernandez-Sarabia, Bischoff: Bcl-2 associates with the ras-related protein R-ras p23. in Nature 1993 (PubMed)
    Show all 2 references for ABIN667734

  2. Human BCL2 Protein expressed in Wheat germ - ABIN1346542 : Su, Guo, Qi: Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy. in Biochimica et biophysica acta 2014 (PubMed)

More Proteins for BCL2 Interaction Partners

Mouse (Murine) B-Cell CLL/lymphoma 2 (BCL2) interaction partners

  1. Bcl-2 is an essential regulator in the survival of doublecortin (show DCX Proteins)-expressing immature neurons.

  2. Results show that the deletion of BCL-2, on its own or in concert with MCL-1 (show MCL1 Proteins), does not affect platelet production or platelet lifespan.

  3. the expression changes observed within the BCL2 family did not depend on STAT3 (show STAT3 Proteins) signalling, in line with its initiating role early in the process, but rather appear to result from relief of repression by STAT5 (show STAT5A Proteins).

  4. Bcl-2-caspase-9 (show CASP9 Proteins) apoptosis pathway was clearly activated in the testis of asthmatic mice with the increased expression of apoptosis-related proteins.

  5. Bcl-2 expression in the endothelium plays a significant role during postnatal retinal vascularization, and pathological choroidal but not retinal neovascularization, suggesting vascular bed specific Bcl-2 function in the endothelium

  6. Studied the protein expression of BCL2, FGF-R1, and HSP70 (show HSP70 Proteins) after short-time magnetic thermoablative tumor treatment using immunohistochemistry in a human BT474 breast cancer mouse xenograft model.

  7. The increased level of Bcl-2 caused by the decrease in miR (show MLXIP Proteins)-181c protected mitochondrial morphology from the tumour necrosis factor alpha (show TNF Proteins)-induced apoptosis.

  8. The expression of GRP78 (show HSPA5 Proteins) and Bcl-2 was significantly higher in astrocytes pretreated with recombinant Shh (show SHH Proteins). These findings suggest that the expression of Shh (show SHH Proteins) may inhibit cell death by activating Bcl-2 through a GRP78 (show HSPA5 Proteins)-dependent pathway.

  9. Knockdown of NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) subunit expression can significantly inhibit the growth of nude mouse Lewis tumour cell xenografts by inducing tumour cell apoptosis and downregulating pro-apoptotic protein Bcl-2 expression.

  10. Studies suggest targeting the BCL-2 family for treating diseases with dysregulated apoptosis.

Guinea Pig B-Cell CLL/lymphoma 2 (BCL2) interaction partners

  1. bcl-2 and bax (show BAX Proteins) were expressed strongly in denervated guinea-pig facial muscle. [bcl-2; bax (show BAX Proteins)]

Human B-Cell CLL/lymphoma 2 (BCL2) interaction partners

  1. The potent antitumor activity of RHL may be mediated through downregulation of Bcl-2 and cyclin D expression and upregulation of BAX (show BAX Proteins) and Bim (show BCL2L11 Proteins) expression.

  2. the results indicated that there is a close correlation between the BCL2 rs17757541 C>G polymorphism and coronary artery disease

  3. the BCL2-938C>A and BAX (show BAX Proteins)-248G>A SNPs significantly associated with platinum-based chemotherapy response, PFS and OS of patients with advanced NSCLC.

  4. MiR-16 (show GDE1 Proteins) mediated temozolomide-resistance in glioma cells by modulation of apoptosis via targeting Bcl-2

  5. Dual-poly-siRNA carrying glycol chitosan nanoparticles demonstrated successful VEGF (show VEGFA Proteins)/Bcl2 gene silencing in prostate tumors.

  6. the recently proposed new therapies employing bcl-2 inhibitors prompted the potential use of bax (show BAX Proteins)/bcl-2 ratio to identify patients putatively resistant to these molecules.

  7. study showed that De novo MYCyBCL2 double-hit BCP (show OPN1SW Proteins)-ALL is a rare disease that also occurs in pediatric and young adult patients and associated with complex karyotypes and poor prognosis. Younger patients may benefit from intensified chemotherapy.

  8. Results show that PCAF (show KAT2B Proteins) can induce cell apoptosis by modulating a GLI1 (show GLI1 Proteins)/Bcl-2/BAX (show BAX Proteins) axis that in turn suppresses HCC (show FAM126A Proteins) progression.

  9. Bcl-2 dependent NB cell lines are exquisitely sensitive to ABT-199 . Treatment with ABT-199 displaces Bim (show BCL2L11 Proteins) from Bcl-2 in NB to activate caspase 3 (show CASP3 Proteins), confirming the restoration of mitochondrial apoptosis

  10. Co-administration of the mTORC1/TORC2 (show CRTC2 Proteins) inhibitor INK128 and the Bcl-2/Bcl-xL (show BCL2L1 Proteins) antagonist ABT-737 kills human myeloid leukemia (show BCL11A Proteins) cells through Mcl-1 (show MCL1 Proteins) down-regulation and AKT (show AKT1 Proteins) inactivation.

Cow (Bovine) B-Cell CLL/lymphoma 2 (BCL2) interaction partners

  1. Over-expression of STC-1 (show STC1 Proteins) up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 (show CASP3 Proteins) production in the damaged cells. Findings from this study suggest that STC-1 (show STC1 Proteins) plays a protective role in intestinal cells through an antioxidant mechanism.

  2. BoHV-5 replication apparently modulates BCL-2 expression and gene transcription, enhancing production of virus progeny, but does not increase Bax (show BAX Proteins) expression.

  3. G3139, a BCL-2 antisesnse oligonucleotide is a promising candidate for treatment of patients with imatinib-resistant Ph-positive leukemia.

  4. role of vascular endothelial growth factor receptor-1 (show FLT1 Proteins) in Bcl-2 expression

  5. apoptosis-inducing factor (show AIFM1 Proteins) was expressed in luminal alveolar cells and, in concert with a change in bax (show BAX Proteins) protein to bcl-2 protein ratio, might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses

  6. mRNA expression of Bax (show BAX Proteins), Bcl-2, caspase-3 (show CASP3 Proteins) and-7 cannot be used as a reliable apoptosis detection method.

  7. These results propose an additional mechanism whereby resveratrol may exert its cardioprotective effects and suggest a key role for Bcl-2 in the resveratrol anti-apoptotic action, especially in disrupting peroxynitrite-triggered mitochondrial pathway.

Rabbit B-Cell CLL/lymphoma 2 (BCL2) interaction partners

  1. Cinobufagin can remarkably inhibit the proliferation and induce the apoptosis of lens epithelial cells by increasing expression of bax (show BAX Proteins) and decreasing expression of bcl2.

  2. Elevated local temperature of the testis buried in the inguinal pocket increases the apoptosis of spermatogenic cells, and the spermatogenic cell apoptosis is highly correlated with the decreased expression of Bcl-2 and increased expression of Bax (show BAX Proteins).

  3. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 (show TP53 Proteins) and decrease in the antiapoptotic BCl2 proteins.

  4. Isoflurane delayed preconditioning can inhibit the apoptosis of myocardium by up-regulating the expression of Bcl-2 and down-regulating the activation of caspase-3 (show CASP3 Proteins).

  5. Data show that the damaged electron transport chain leads to bcl-2 depletion and MPT opening.

Zebrafish B-Cell CLL/lymphoma 2 (BCL2) interaction partners

  1. These results suggest a role for mitochondrial p53 (show TP53 Proteins) activity in promoting hair cell death due to aminoglycosides, likely upstream of Bax (show BAX Proteins) and Bcl2.

  2. Zebrafish gene expressions of P53 (show TP53 Proteins), Bcl-2, Bax (show BAX Proteins) and caspase-3 (show CASP3 Proteins) were elevated after exposure with microcystin-LR under different ambient temperatures.

  3. Analysis using clinical biopsy specimens revealed autophagy and increased levels of BCL2, S1P1 (show S1PR1 Proteins), and ICAM1 (show ICAM1 Proteins) in human T-lymphoblastic lymphoma compared with T-lymphoblastic leukemia.

  4. Real-time RT-PCR revealed acetaminophen treatment of zebrafish embryos decreased the expression of cox2 and bcl2, but increased p53 (show TP53 Proteins) expression.

  5. Leukemia onset was dramatically accelerated in transgenic fish overexpressing human Notch1 (show NOTCH1 Proteins) and fish bcl-2, indicating synergy between the Notch (show NOTCH1 Proteins) pathway and the bcl2-mediated antiapoptotic pathway.

BCL2 Protein Profile

Protein Summary

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.

Alternative names and synonyms associated with BCL2

  • B-cell CLL/lymphoma 2 (BCL2)
  • B-cell CLL/lymphoma 2 (LOC100224888)
  • B cell leukemia/lymphoma 2 (Bcl2)
  • B-cell CLL/lymphoma 2 (Bcl2)
  • B-cell CLL/lymphoma 2 protein (BCL-2)
  • B-cell leukemia/lymphoma 2 (bcl2)
  • AW986256 protein
  • bcl-2 protein
  • Bcl2 protein
  • C430015F12Rik protein
  • D630044D05Rik protein
  • D830018M01Rik protein
  • PPP1R50 protein

Protein level used designations for B-Cell CLL/lymphoma 2 Proteins (BCL2)

B-cell lymphoma protein 2 , B-cell leukemia/lymphoma 2 , apoptosis regulator Bcl-2 , B-cell CLL/lymphoma 2 , protein phosphatase 1, regulatory subunit 50 , B cell lymphoma 2 associated oncogene , Bcl2-like protein , BCL2B-cell CLL/lymphoma 2 , PCKBCL2 , Bcl2 , zBlp2

GENE ID SPECIES
738409 Pan troglodytes
100224888 Taeniopygia guttata
12043 Mus musculus
100733337 Cavia porcellus
596 Homo sapiens
24224 Rattus norvegicus
403416 Canis lupus familiaris
493934 Felis catus
100049703 Sus scrofa
281020 Bos taurus
396282 Gallus gallus
100009447 Oryctolagus cuniculus
570772 Danio rerio
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