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Browse our BCL2 Proteins (BCL2)

Full name:
B-Cell CLL/lymphoma 2 Proteins (BCL2)
On are 22 B-Cell CLL/lymphoma 2 (BCL2) Proteins from 9 different suppliers available. Additionally we are shipping BCL2 Antibodies (764) and BCL2 Kits (32) and many more products for this protein. A total of 852 BCL2 products are currently listed.
AW986256, bcl-2, Bcl2, C430015F12Rik, D630044D05Rik, D830018M01Rik, PPP1R50
list all proteins Gene Name GeneID UniProt
BCL2 12043 P10417
BCL2 596 P10415
Rat BCL2 BCL2 24224 P49950

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BCL2 Proteins (BCL2) by Origin

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Top referenced BCL2 Proteins

  1. Human BCL2 Protein expressed in Escherichia coli (E. coli) - ABIN667734 : Fernandez-Sarabia, Bischoff: Bcl-2 associates with the ras-related protein R-ras p23. in Nature 1993 (PubMed)
    Show all 2 references for ABIN667734

  2. Human BCL2 Protein expressed in Wheat germ - ABIN1346542 : Su, Guo, Qi: Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy. in Biochimica et biophysica acta 2014 (PubMed)

More Proteins for BCL2 Interaction Partners

Mouse (Murine) B-Cell CLL/lymphoma 2 (BCL2) interaction partners

  1. the expression changes observed within the BCL2 family did not depend on STAT3 (show STAT3 Proteins) signalling, in line with its initiating role early in the process, but rather appear to result from relief of repression by STAT5 (show STAT5A Proteins).

  2. Bcl-2-caspase-9 (show CASP9 Proteins) apoptosis pathway was clearly activated in the testis of asthmatic mice with the increased expression of apoptosis-related proteins.

  3. Bcl-2 expression in the endothelium plays a significant role during postnatal retinal vascularization, and pathological choroidal but not retinal neovascularization, suggesting vascular bed specific Bcl-2 function in the endothelium

  4. Studied the protein expression of BCL2, FGF-R1, and HSP70 (show HSP70 Proteins) after short-time magnetic thermoablative tumor treatment using immunohistochemistry in a human BT474 breast cancer mouse xenograft model.

  5. The increased level of Bcl-2 caused by the decrease in miR (show MLXIP Proteins)-181c protected mitochondrial morphology from the tumour necrosis factor alpha (show TNF Proteins)-induced apoptosis.

  6. The expression of GRP78 (show HSPA5 Proteins) and Bcl-2 was significantly higher in astrocytes pretreated with recombinant Shh (show SHH Proteins). These findings suggest that the expression of Shh (show SHH Proteins) may inhibit cell death by activating Bcl-2 through a GRP78 (show HSPA5 Proteins)-dependent pathway.

  7. Knockdown of NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) subunit expression can significantly inhibit the growth of nude mouse Lewis tumour cell xenografts by inducing tumour cell apoptosis and downregulating pro-apoptotic protein Bcl-2 expression.

  8. Studies suggest targeting the BCL-2 family for treating diseases with dysregulated apoptosis.

  9. Deletion of AU-rich elements within the Bcl2 3'UTR reduces protein expression and B cell survival

  10. The nuclear-penetrating anti-dsDNA autoantibodies could possibly function as a pathogenic factor for lupus nephritis by up-regulating ERK (show EPHB2 Proteins) activation and Bcl-2 production in mesangial cells.

Guinea Pig B-Cell CLL/lymphoma 2 (BCL2) interaction partners

  1. bcl-2 and bax (show BAX Proteins) were expressed strongly in denervated guinea-pig facial muscle. [bcl-2; bax (show BAX Proteins)]

Human B-Cell CLL/lymphoma 2 (BCL2) interaction partners

  1. Bcl-2 is required for efficient intestinal transformation.

  2. CD10 (show MME Proteins) and Bcl2 expression in tumor cells could give convincing diagnostic value to distinguish squamous cell carcinoma from seborrheic keratosis

  3. Survivin (show BIRC5 Proteins), Bcl-2, and KAI1 (show CD82 Proteins) are metastasis-related factors in cervical cancer. Overexpression of survivin (show BIRC5 Proteins) and Bcl-2, and low expression of KAI1 (show CD82 Proteins) promotes cervical cancer progress and metastasis.

  4. Similar clinical features in follicular lymphomas were observed with and without breaks in the BCL2 locus.

  5. these data indicate that IL-6 (show IL6 Proteins) inhibits starvation-induced autophagy and that p-STAT3 (show STAT3 Proteins) mediates the signal transduction from IL-6 (show IL6 Proteins) to downstream proteins including Bcl-2 and Beclin1 (show BECN1 Proteins)

  6. oligonucleotide-mediated treatment could be more effective when directed towards KI-67 (show MKI67 Proteins) and BCL2. This could be accomplished by dual monospecific targeting KI-67 (show MKI67 Proteins) and BCL2

  7. we discuss the biology of the intrinsic pathway of apoptosis, early attempts to target BCL-2 clinically, and the recent promising results with the BCL-2 antagonist venetoclax (ABT-199) in clinical trials in hematologic malignancies

  8. Dysadherin (show FXYD5 Proteins)-silenced side population cells exhibited reduced expression of Bcl-2 and Bax (show BAX Proteins) compared with that prior to silencing.

  9. These data indicate that blood BCL2-MBR (show TSPO Proteins) translocations represent lymphoma precursor clones with malignant potential.

  10. Magnetic iron oxide nanoparticles can induce the autophagy in blood cells by regulating the Beclin 1 (show BECN1 Proteins)/Bcl-2/Atg14/VPS34 (show PIK3C3 Proteins) complex.

Cow (Bovine) B-Cell CLL/lymphoma 2 (BCL2) interaction partners

  1. Over-expression of STC-1 (show STC1 Proteins) up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 (show CASP3 Proteins) production in the damaged cells. Findings from this study suggest that STC-1 (show STC1 Proteins) plays a protective role in intestinal cells through an antioxidant mechanism.

  2. BoHV-5 replication apparently modulates BCL-2 expression and gene transcription, enhancing production of virus progeny, but does not increase Bax (show BAX Proteins) expression.

  3. G3139, a BCL-2 antisesnse oligonucleotide is a promising candidate for treatment of patients with imatinib-resistant Ph-positive leukemia.

  4. role of vascular endothelial growth factor receptor-1 (show FLT1 Proteins) in Bcl-2 expression

  5. apoptosis-inducing factor (show AIFM1 Proteins) was expressed in luminal alveolar cells and, in concert with a change in bax (show BAX Proteins) protein to bcl-2 protein ratio, might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses

  6. mRNA expression of Bax (show BAX Proteins), Bcl-2, caspase-3 (show CASP3 Proteins) and-7 cannot be used as a reliable apoptosis detection method.

  7. These results propose an additional mechanism whereby resveratrol may exert its cardioprotective effects and suggest a key role for Bcl-2 in the resveratrol anti-apoptotic action, especially in disrupting peroxynitrite-triggered mitochondrial pathway.

Rabbit B-Cell CLL/lymphoma 2 (BCL2) interaction partners

  1. Cinobufagin can remarkably inhibit the proliferation and induce the apoptosis of lens epithelial cells by increasing expression of bax (show BAX Proteins) and decreasing expression of bcl2.

  2. Elevated local temperature of the testis buried in the inguinal pocket increases the apoptosis of spermatogenic cells, and the spermatogenic cell apoptosis is highly correlated with the decreased expression of Bcl-2 and increased expression of Bax (show BAX Proteins).

  3. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 (show TP53 Proteins) and decrease in the antiapoptotic BCl2 proteins.

  4. Isoflurane delayed preconditioning can inhibit the apoptosis of myocardium by up-regulating the expression of Bcl-2 and down-regulating the activation of caspase-3 (show CASP3 Proteins).

  5. Data show that the damaged electron transport chain leads to bcl-2 depletion and MPT opening.

Zebrafish B-Cell CLL/lymphoma 2 (BCL2) interaction partners

  1. These results suggest a role for mitochondrial p53 (show TP53 Proteins) activity in promoting hair cell death due to aminoglycosides, likely upstream of Bax (show BAX Proteins) and Bcl2.

  2. Zebrafish gene expressions of P53 (show TP53 Proteins), Bcl-2, Bax (show BAX Proteins) and caspase-3 (show CASP3 Proteins) were elevated after exposure with microcystin-LR under different ambient temperatures.

  3. Analysis using clinical biopsy specimens revealed autophagy and increased levels of BCL2, S1P1 (show S1PR1 Proteins), and ICAM1 (show ICAM1 Proteins) in human T-lymphoblastic lymphoma compared with T-lymphoblastic leukemia.

  4. Real-time RT-PCR revealed acetaminophen treatment of zebrafish embryos decreased the expression of cox2 and bcl2, but increased p53 (show TP53 Proteins) expression.

  5. Leukemia onset was dramatically accelerated in transgenic fish overexpressing human Notch1 (show NOTCH1 Proteins) and fish bcl-2, indicating synergy between the Notch (show NOTCH1 Proteins) pathway and the bcl2-mediated antiapoptotic pathway.

BCL2 Protein Profile

Protein Summary

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.

Alternative names and synonyms associated with BCL2

  • B-cell CLL/lymphoma 2 (BCL2)
  • B-cell CLL/lymphoma 2 (LOC100224888)
  • B cell leukemia/lymphoma 2 (Bcl2)
  • B-cell CLL/lymphoma 2 (Bcl2)
  • B-cell CLL/lymphoma 2 protein (BCL-2)
  • B-cell leukemia/lymphoma 2 (bcl2)
  • AW986256 protein
  • bcl-2 protein
  • Bcl2 protein
  • C430015F12Rik protein
  • D630044D05Rik protein
  • D830018M01Rik protein
  • PPP1R50 protein

Protein level used designations for B-Cell CLL/lymphoma 2 Proteins (BCL2)

B-cell lymphoma protein 2 , B-cell leukemia/lymphoma 2 , apoptosis regulator Bcl-2 , B-cell CLL/lymphoma 2 , protein phosphatase 1, regulatory subunit 50 , B cell lymphoma 2 associated oncogene , Bcl2-like protein , BCL2B-cell CLL/lymphoma 2 , PCKBCL2 , Bcl2 , zBlp2

738409 Pan troglodytes
100224888 Taeniopygia guttata
12043 Mus musculus
100733337 Cavia porcellus
596 Homo sapiens
24224 Rattus norvegicus
403416 Canis lupus familiaris
493934 Felis catus
100049703 Sus scrofa
281020 Bos taurus
396282 Gallus gallus
100009447 Oryctolagus cuniculus
570772 Danio rerio
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