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|Antigen||Jun Proto-Oncogene (JUN) Antibodies|
|Epitope||AA 26-175 Alternatives|
|Reactivity||Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This C-JUN antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
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Product Details anti-C-JUN AntibodyTarget Details C-JUN Application Details Handling References for anti-C-JUN antibody (ABIN967903) Images
|Cross-Reactivity||Human, Chicken, Dog (Canine), Rat (Rattus)|
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|Immunogen||Mouse c-Jun aa. 26-175|
Target Details C-JUNProduct Details anti-C-JUN Antibody Application Details Handling References for anti-C-JUN antibody (ABIN967903) Images back to top
|Alternative Name||Jun (JUN Antibody Abstract)|
|Background||The activator protein transcription factor (AP-1) was identified as a protein that recognizes specific sequences in the cis-control regions of the SV40 virus and the human metallothionein IIA gene. AP-1 is composed of protein products of two different gene families: jun and fos. The AP-1 transcription factor is either a homodimer of Jun proteins or a heterodimer of Jun and Fos proteins. The transcriptional activity of Jun is enhanced by phosphorylation in its activation domain at Ser63 and Ser73. Phosphorylation at both sites is necessary for stimulating the activating function of Jun. Jun is phosphorylated by JNK protein kinases that are activated by the same signals that potentiate Jun activity. This antibody is routinely tested by western blot analysis.|
|Molecular Weight||39 kDa|
|Pathways||MAPK Signaling, RTK Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Autophagy, Signaling of Hepatocyte Growth Factor Receptor|
Application DetailsProduct Details anti-C-JUN Antibody Target Details C-JUN Handling References for anti-C-JUN antibody (ABIN967903) Images back to top
Related Products: ABIN968536, ABIN967389
|Restrictions||For Research Use only|
HandlingProduct Details anti-C-JUN Antibody Target Details C-JUN Application Details References for anti-C-JUN antibody (ABIN967903) Images back to top
|Buffer||Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at -20° C.|
References for anti-C-JUN antibody (ABIN967903)Product Details anti-C-JUN Antibody Target Details C-JUN Application Details Handling Images back to top
|Product cited in:||
Doray, Ghosh, Griffith, Geuze, Kornfeld: "Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network." in: Science (New York, N.Y.), Vol. 297, Issue 5587, pp. 1700-3, 2002
He, Stepulak, Holmström, Omary, Eriksson: "The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase." in: The Journal of biological chemistry, Vol. 277, Issue 13, pp. 10767-74, 2002
Chang, Nakajima, Illenye, Lee, Honjo, Makiyama, Fujiwara, Mizuta, Sawai, Saida, Mitsui, Heintz, Magae: "Caspase-dependent apoptosis by ectopic expression of E2F-4." in: Oncogene, Vol. 19, Issue 41, pp. 4713-20, 2000
Taupin, Wu, Jeon, Devaney, Wang, Podolsky: "The trefoil gene family are coordinately expressed immediate-early genes: EGF receptor- and MAP kinase-dependent interregulation." in: The Journal of clinical investigation, Vol. 103, Issue 9, pp. R31-8, 1999
Lamph, Wamsley, Sassone-Corsi, Verma: "Induction of proto-oncogene JUN/AP-1 by serum and TPA." in: Nature, Vol. 334, Issue 6183, pp. 629-31, 1988
ImagesProduct Details anti-C-JUN Antibody Target Details C-JUN Application Details Handling References for anti-C-JUN antibody (ABIN967903) back to top