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This study demonstrate that phosphorylation of Tau at Serine 262 by the kinase domain of DAPK1 mediates spine damage and the subsequent neuronal death in ischemic stroke.
DAPK1-p53 (show TP53 ELISA Kits) interaction is a preferred target for therapeutic intervention of stroke.
Suggest that DAPK1 is a novel regulator of tau protein abundance, and that DAPK1 upregulation might contribute to tau-related pathologies in Alzheimer disease.
the DAPK1-p53 (show TP53 ELISA Kits) interaction is a signaling point of convergence of necrotic and apoptotic pathways
a new function of DAPK in suppressing TNF (show TNF ELISA Kits)-induced STAT3 (show STAT3 ELISA Kits) activation, was identified.
TSC2 (show TSC2 ELISA Kits) binds to the death domain of DAPK. This interaction is required for TSC2 (show TSC2 ELISA Kits) to reduce DAPK protein levels and half-life. DAPK is regulated by the lysosome pathway. Lysosome inhibition blocks TSC2 (show TSC2 ELISA Kits)-mediated degradation of DAPK.
Results identify DAPK as a molecule required for full production of IL-1beta (show IL1B ELISA Kits) and functional assembly of the NLRP3 (show NLRP3 ELISA Kits) inflammasome.
Study reports that cerebral ischemia recruits death-associated protein kinase 1 (DAPK1) into the NMDA receptor NR2B (show GRIN2B ELISA Kits) protein complex in the cortex of adult mice.
Death-associated protein kinase (DAPK) is regulated by DANGER which binds directly to DAPK and inhibits catalytic activity.
cellular activities of DAPK are critical for antagonizing caspase (show CASP3 ELISA Kits)-dependent apoptosis to promote cell survival under normal cell growth conditions.
The result suggests that DAPK promoter methylation is significantly increased in bladder cancer patients compared to normal controls. DAPK promoter methylation could serve as a biomarker for bladder cancer detection and management.
Down-regulation of mRNA expression was found in cases in which CASP8 (show CASP8 ELISA Kits), TMS1 (show SERINC3 ELISA Kits) and DAPK were hypermethylated.
A transcription factor complex consisting of ATF6 (show ATF6 ELISA Kits) (an endoplasmic reticulum-resident factor) and C/EBP-beta (show CEBPB ELISA Kits) is required for the IFN-gamma-induced (show SAMHD1 ELISA Kits) expression of DAPK1 IFN-gamma-induced (show SAMHD1 ELISA Kits) proteolytic processing of ATF6 (show ATF6 ELISA Kits) and phosphorylation of C/EBP-beta (show CEBPB ELISA Kits) are obligatory for the formation of this transcriptional complex
the present study demonstrated that DAPK contributed to the Hcyinduced endothelial apoptosis via modulation of Bcl2 (show BCL2 ELISA Kits)/Bax (show BAX ELISA Kits) expression levels and activation of caspase 3 (show CASP3 ELISA Kits)
DAPK seems to be a major player that influences the migratory capability of disseminating tumor cells and possibly affects the dynamic interface between pro- and anti-survival factors at the invasion front of colorectal cancer.
The sensitivity was found to be 62% and 83% for DAPK1 and SOX1 (show SOX1 ELISA Kits), respectively, when analyzed separately in the singleplex assay, but increased to 90% in the multiplex assay when either or both of the SOX1 (show SOX1 ELISA Kits) and the DAPK1 gene promoters showed methylation.
Authors observed the cleavage of ATF6 (show ATF6 ELISA Kits), the phosphorylation of MRLC, and the expression of death-associated protein kinase (DAPK1) by western blotting; the transcription of DAPK1 by RT-PCR; and the subcellular localization of ATF6 (show ATF6 ELISA Kits) and mAtg9 (show ATG9A ELISA Kits) by immunofluorescence.
testing for DNA methylations of MGMT (show MGMT ELISA Kits) plus DAPK1 genes holds some promise for high grade cervical disease screening
DAPK-1 and MLH1 (show MLH1 ELISA Kits) methylation correlated inversely in tumors in the middle-third of the stomach
Results show that CYP1B1 (show CYP1B1 ELISA Kits) may promote renal cell carcinoma development by inducing CDC20 (show CDC20 ELISA Kits) expression and inhibiting apoptosis through the down-regulation of DAPK1.
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.
death-associated protein kinase 1
, death-associated protein kinase 1-like
, DAP kinase 1