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This study demonstrate that phosphorylation of Tau at Serine 262 by the kinase domain of DAPK1 mediates spine damage and the subsequent neuronal death in ischemic stroke.
DAPK1-p53 (show TP53 ELISA Kits) interaction is a preferred target for therapeutic intervention of stroke.
Suggest that DAPK1 is a novel regulator of tau protein abundance, and that DAPK1 upregulation might contribute to tau-related pathologies in Alzheimer disease.
the DAPK1-p53 (show TP53 ELISA Kits) interaction is a signaling point of convergence of necrotic and apoptotic pathways
a new function of DAPK in suppressing TNF (show TNF ELISA Kits)-induced STAT3 (show STAT3 ELISA Kits) activation, was identified.
TSC2 (show TSC2 ELISA Kits) binds to the death domain of DAPK. This interaction is required for TSC2 (show TSC2 ELISA Kits) to reduce DAPK protein levels and half-life. DAPK is regulated by the lysosome pathway. Lysosome inhibition blocks TSC2 (show TSC2 ELISA Kits)-mediated degradation of DAPK.
Results identify DAPK as a molecule required for full production of IL-1beta (show IL1B ELISA Kits) and functional assembly of the NLRP3 (show NLRP3 ELISA Kits) inflammasome.
Study reports that cerebral ischemia recruits death-associated protein kinase 1 (DAPK1) into the NMDA receptor NR2B (show GRIN2B ELISA Kits) protein complex in the cortex of adult mice.
Death-associated protein kinase (DAPK) is regulated by DANGER which binds directly to DAPK and inhibits catalytic activity.
cellular activities of DAPK are critical for antagonizing caspase (show CASP3 ELISA Kits)-dependent apoptosis to promote cell survival under normal cell growth conditions.
Authors observed the cleavage of ATF6 (show ATF6 ELISA Kits), the phosphorylation of MRLC, and the expression of death-associated protein kinase (DAPK1) by western blotting; the transcription of DAPK1 by RT-PCR; and the subcellular localization of ATF6 (show ATF6 ELISA Kits) and mAtg9 (show ATG9A ELISA Kits) by immunofluorescence.
testing for DNA methylations of MGMT (show MGMT ELISA Kits) plus DAPK1 genes holds some promise for high grade cervical disease screening
DAPK-1 and MLH1 (show MLH1 ELISA Kits) methylation correlated inversely in tumors in the middle-third of the stomach
Results show that CYP1B1 (show CYP1B1 ELISA Kits) may promote renal cell carcinoma development by inducing CDC20 (show CDC20 ELISA Kits) expression and inhibiting apoptosis through the down-regulation of DAPK1.
The frequency of DAPK methylation was significantly higher in lung cancer than in non-malignant lung tissues.
Our meta-analysis results reveal that DAPK promoter methylation might be associated with tumor metastasis and poor prognosis in NSCLC patients, although no correlation with histological types and TNM (show ODZ1 ELISA Kits) stage in NSCLC patients were found.
Results identified MGMT (show MGMT ELISA Kits) and DAPK1 as predictors of nodal metastasis in oral and oropharyngeal squamous cell carcinoma with a high predictive value and specificity and sensitivity.
Viral infection induced DAPK1-IRF7 (show IRF7 ELISA Kits) and DAPK1-IRF3 (show IRF3 ELISA Kits) interactions and overexpression of DAPK1 enhanced virus-induced activation of the interferon (show IFNA ELISA Kits)-stimulated response element (ISRE) and IFN-beta (show IFNB1 ELISA Kits) promoters and the expression of the IFNB1 (show IFNB1 ELISA Kits) gene.
DAPK1 is highly expressed in the peritumoral region of glioblastoma multiforme brain neoplasms.
A significant strong association between DAPK1 promoter methylation and CC was shown and confirmed independently by histological tumor type, method used to evaluate methylation and source of control samples.
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.
death-associated protein kinase 1
, death-associated protein kinase 1-like
, DAP kinase 1