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These data reveal a novel role for Elk1 regulating ITGB6 expression and highlight how dysregulation of Elk1 can contribute to human disease.
Downregulated expression of transcriptional activator ELK-1 may play an important role in the pathogenesis of atrial fibrillation.
ELK1 is likely to be activated in prostate cancer cells and promote tumor progression. Furthermore, silodosin that inactivates ELK1 in prostate cancer cells not only inhibits their growth but also enhances the cytotoxic activity of gemcitabine.
results suggest that ELK1 plays an important role in bladder tumorigenesis and cancer progression.
Negative feedback regulation of AXL (show AXL ELISA Kits) by miR (show MLXIP ELISA Kits)-34a modulates apoptosis in lung cancer cells by activating the transcription factor ELK1 via the JNK (show MAPK8 ELISA Kits) signaling pathway.
These findings suggest that PKCalpha (show PKCa ELISA Kits) expression in HCC (show FAM126A ELISA Kits) could be stimulated by the formation of MZF-1 (show ZFP42 ELISA Kits)/Elk-1 complex, which directly binds to the PKCalpha (show PKCa ELISA Kits) promoter.
interleukin-1beta (IL-1beta (show IL1B ELISA Kits))-induced IER3 (show IER3 ELISA Kits) expression is mediated by the ERK1/2 (show MAPK1/3 ELISA Kits) target, transcription factor Elk-1.
Data show that afatinib reduced Elk-1 transcription factor binding to the CIP2A (show KIAA1524 ELISA Kits) protein promoter and suppressed CIP2A (show KIAA1524 ELISA Kits) transcription.
TNF-alpha (show TNF ELISA Kits) modulation of intestinal epithelial tight junction barrier is regulated by ERK1/2 (show MAPK1/3 ELISA Kits) activation of Elk-1.
Analysis implies a role of ELK-1 in the differences between pluripotent stem cells with distinct X chromosome inactivation statuses.
A role for Elk-1 in the transcriptional regulation of DUSP5 (show DUSP5 ELISA Kits)
novel GrB-EH(ITSN (show ITSN1 ELISA Kits))-dependent pathogenic p38(MAPK (show MAPK14 ELISA Kits))/Elk-1 signaling pathway involved in the poorly understood process of PL formation in severe PAH.
Data show that formation of a Krupple-like factor KLF4 (show KLF4 ELISA Kits), pELK-1, and histone de-acetylase 2 (HDAC2 (show HDAC2 ELISA Kits)) multiprotein complex dependent on the SM22alpha (show TAGLN ELISA Kits) G/C Repressor element.
increased protein levels, phosphorylation and nuclear localization of Elk-1 observed in exon-1 and full-length Huntington's disease models could be a compensatory mechanism activated by striatal cells that contributes to neuroprotection
Fibroblast growth factor 21 (show FGF21 ELISA Kits) induces glucose transporter-1 (show SLC2A1 ELISA Kits) expression through activation of the serum response factor/Ets (show ETS1 ELISA Kits)-like protein-1 in adipocytes
Elk-1 phosphorylation downstream from extracellular signal-regulated kinase is a key molecular event involved in long-term neuronal and behavioral adaptations to cocaine.
we aimed to identify the critical promoter regions of SPG4 (show SPAST ELISA Kits) gene and effects of Elk1 on SPG4 (show SPAST ELISA Kits) gene expression
Results suggest a combined role for the transcription factors NF-kappaB (show NFKB1 ELISA Kits) and Elk-1 in the upregulation of AT(1)R in the CATH.a cell neuronal model.
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. The gene is brain-specific, and located in the neocortex and the striatum. It may be involved in cellular excitability of restricted neurons in the central nervous system.
ETS domain-containing protein Elk-1
, ETS-like gene 1
, tyrosine kinase (ELK1) oncogene
, ELK channel 1
, brain-specific eag-like channel 2
, ether-a-go-go K(+) channel family member
, ether-a-go-go-like potassium channel 1
, potassium voltage-gated channel subfamily H member 4
, voltage-gated potassium channel subunit Kv12.3