Browse our ERK2 Proteins (MAPK1)

Full name:
Mitogen-Activated Protein Kinase 1 Proteins (MAPK1)
On www.antibodies-online.com are 39 Mitogen-Activated Protein Kinase 1 (MAPK1) Proteins from 13 different suppliers available. Additionally we are shipping ERK2 Antibodies (366) and ERK2 Kits (53) and many more products for this protein. A total of 476 ERK2 products are currently listed.
Synonyms:
9030612K14Rik, AA407128, ATMPK1, ATMPK2, AU018647, C78273, erk, erk2, ert1, F14N23.9, F14N23_9, mapk, mapk1, mapk1a, mapk1b, mapk2, MITOGEN-ACTIVATED PROTEIN KINASE, mitogen-activated protein kinase 1, mitogen-activated protein kinase homolog 2, mpk1, p38, p40, p41, p41mapk, p42mapk, prkm1, prkm2, T30E16.13, T30E16_13, Xp42, zERK2
list all proteins Gene Name GeneID UniProt
MAPK1 5594 P28482
MAPK1 26413 P63085
MAPK1 116590 P63086

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ERK2 Proteins (MAPK1) by Origin

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Top referenced ERK2 Proteins

  1. Human ERK2 Protein expressed in Baculovirus infected Insect Cells - ABIN2001936 : Slack, Seternes, Gabrielsen, Keyse: Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1. in The Journal of biological chemistry 2001 (PubMed)
    Show all 2 references for 2001936

  2. Human ERK2 Protein expressed in Escherichia coli (E. coli) - ABIN666923 : Hu, Xie, Onishi, Yu, Jiang, Lin, Rho, Woodard, Wang, Jeong, Long, He, Wade, Blackshaw, Qian, Zhu: Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling. in Cell 2009 (PubMed)
    Show all 2 references for 666923

  3. Human ERK2 Protein expressed in Wheat germ - ABIN1310256 : Abeydeera, Egli, Cox, Mercier, Conde, Pallan, Mizurini, Sierant, Hibti, Hassell, Wang, Liu, Liu, Martinez, Sood, Lybrand, Frydman, Monteiro, Gomer, Nawrot, Yang: Evoking picomolar binding in RNA by a single phosphorodithioate linkage. in Nucleic acids research 2016 (PubMed)

More Proteins for ERK2 Interaction Partners

Arabidopsis thaliana Mitogen-Activated Protein Kinase 1 (MAPK1) interaction partners

  1. MKP1 (show DUSP1 Proteins) is a negative regulator of signaling pathways required for some, but not all, early and late pathogen-associated molecular pattern responses.

  2. MKP1 (show DUSP1 Proteins) and PTP1 act redundantly to suppress salicylic acid and camalexin biosynthesis, and regulate growth homeostasis and PR gene expression in an MPK3 (show MAPK3 Proteins)- and MPK6 (show MAPK6 Proteins)-dependent manner.

  3. Regulation of AtMPK1/2 kinase activity in Arabidopsis might be under the control of signals involved in different kinds of stress.

  4. AtMKP2, a novel MKP protein in Arabidopsis, acts upon MPK3 (show MAPK3 Proteins) and -6, and serves as a positive regulator of the cellular response to oxidant challenge

Cow (Bovine) Mitogen-Activated Protein Kinase 1 (MAPK1) interaction partners

  1. The present results suggest that demecolcine might contribute to the activation of the Mos (show MOCOS Proteins)/MAPK pathway and affect spindle structure

  2. MAPK1 upregulated milk protein (show CSN2 Proteins) synthesis through the Stat5 (show STAT5A Proteins) and mTOR (show FRAP1 Proteins) pathways.

  3. Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.

  4. ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation.

  5. Cyclin-dependent kinase (show CDK1 Proteins) inhibition did not affect the expression (mRNA and protein levels) and localization of maturation promoting factor(MPF (show MSLN Proteins)) and MAPK, and had nearly no effect on kinase activities during maturation.

  6. Thrombospondin 1 (show THBS1 Proteins), fibronectin (show FN1 Proteins), and vitronectin (show VTN Proteins) are differentially dependent upon RAS, ERK1/2, and p38 (show MAPK14 Proteins) for induction of vascular smooth muscle cell chemotaxis.

  7. results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation

  8. These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 (show EGR1 Proteins) nuclear accumulation.

  9. Role of CaMKII (show CAMK2G Proteins) in hydrogen peroxide activation of p38 MAPK (show MAPK14 Proteins)/heat shock protein 27 pathway and ERK1/2

  10. data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.

Zebrafish Mitogen-Activated Protein Kinase 1 (MAPK1) interaction partners

  1. Excess PLAC8 promotes an unconventional ERK2-dependent EMT (show ITK Proteins) in colon cancer.

  2. ERK1/2-Akt1 (show AKT1 Proteins) crosstalk regulates arteriogenesis in mice and zebrafish.

  3. eena (show SH3GL1 Proteins) plays an important role in the development of the myeloid cell through activation of the ERK1 (show MAPK3 Proteins)/ERK2 pathway

  4. ERK1 (show MAPK3 Proteins) and ERK2 target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK2 genes involved in cell-migration, mesendoderm differentiation and patterning were identified.

  5. These results demonstrate that induction of Hsp70 (show HSPA1A Proteins) in response to heat stress is dependent on ERK activation in Pac2 (show PSMG2 Proteins) cells.

  6. Data define distinct roles for ERK1 (show MAPK3 Proteins) and ERK2 in developmental cell migration processes during zebrafish embryogenesis.

Human Mitogen-Activated Protein Kinase 1 (MAPK1) interaction partners

  1. Finally, the authors show that EGFR (show EGFR Proteins)-ERK1/2 and beta1-integrin signaling are the main pathways used for bacteria-mediated EGR1 (show EGR1 Proteins) upregulation.

  2. findings show that endothelial MAPKs ERK (show EPHB2 Proteins), p38 (show CRK Proteins), and JNK (show MAPK8 Proteins) mediate diapedesis-related and diapedesis-unrelated functions of ICAM-1 (show ICAM1 Proteins) in cerebral and dermal microvascular endothelial cells (MVECs).

  3. RARRES2 (show RARRES2 Proteins) overexpression in adrenocortical carcinoma cells inhibited Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway activity by promoting beta-catenin (show CTNNB1 Proteins) phosphorylation and degradation, it also inhibited the phosphorylation of p38 mitogen-activated protein kinase (show MAPK14 Proteins). Thus our study identifies RARRES2 (show RARRES2 Proteins) as a novel tumor suppressor for adrenocortical carcinoma, which can function through an immune-independent mechanism.

  4. the direct binding of ERalpha (show ESR1 Proteins)-36 to ERK2 prevents its dephosphorylation by MKP3 (show DUSP6 Proteins) and enhances the downstream signaling. These findings improve our understanding of the regulation of non-genomic estrogen signaling and open new avenues for personalized therapeutic approaches targeting Src (show SRC Proteins) or MEK (show MAP2K1 Proteins) in ERalpha (show ESR1 Proteins)-36-positive patients.

  5. a new ERK2/AP-1 (show FOSB Proteins)/miR (show MLXIP Proteins)-494/PTEN pathway that is responsible for the tumor-suppressive role of NFkappaB2 p100 (show CUX1 Proteins) in cellular transformation.

  6. the mitochondrial morphology of T-cell acute lymphoblastic leukemia cells were altered from elongation to fragmentation because of the extracellular signal-regulated kinase activation-mediated phosphorylation of the pro-fission factor, dynamin-related protein 1 (Drp1 (show DNM1L Proteins)), at residue S616.

  7. ERK2 phosphorylation is mediated by Src (show SRC Proteins) and Csk (show CSK Proteins).

  8. Aberrant expression of sema3c is correlated with poor prognosis of pancreatic ductal adenocarcinoma patients and promotes tumor growth and metastasis by activating ERK1/2 signaling pathway.

  9. Increased staining for phosphorylated ERK1/2 does not correlate to BRAF or KRAS mutations in colorectal neoplasms.

  10. Mutations of MAP2K1 (show MAP2K1 Proteins) are frequent in pediatric-type follicular lymphoma and result in ERK1 (show MAPK3 Proteins)/ERK2 pathway activation.

Mouse (Murine) Mitogen-Activated Protein Kinase 1 (MAPK1) interaction partners

  1. Studies indicate that progesterone receptor transgenic (Pgrcre/+) mitogen inducible gene 6 (Mig-6over) phosphatase and tensin homolog protein (Ptenf/f) knockout mice exhibited an increase of phospho-ERK1/2 and its target genes.

  2. Gpr182 reduction led to increased activation of ERK1/2 in basal and challenge models, demonstrating a potential role for this orphan GPCR in regulating the proliferative capacity of the intestine.

  3. the cooperative role of TLR9 (show TLR9 Proteins) with TLR2 or TLR6 (show TLR6 Proteins) receptors in sensing Brucella, was determined.

  4. tau overexpression mediates the excitatory toxicity induced by E-NMDAR (show GRIN1 Proteins) activation through inhibiting ERK (show EPHB2 Proteins) phosphorylation.

  5. retinoschisin (show RS1 Proteins) is a novel regulator of MAP kinase signalling and exerts an anti-apoptotic effect on retinal cells.

  6. Postnatal chondrocyte-specific deletion of Hdac3 (show HDAC3 Proteins) with an inducible Col2a1 (show COL2A1 Proteins)-Cre caused premature production of pErk1/2 and Mmp13 (show MMP13 Proteins) in the growth plate.

  7. The progress of neurogenesis depended on sustained ERK phosphorylation and resulted in ERK1/2 translocation to the nucleus.

  8. The kinase TPL2 (show MAP3K8 Proteins) activates ERK (show EPHB2 Proteins) and p38 (show CRK Proteins) signaling to promote neutrophilic inflammation

  9. Low frequency pulsed electromagnetic field (PEMF) induced the activation of extracellular signal-regulated kinases ERK1/2, and the phosphorylation level of ERK1/2 increased after 15 min when exposed to PEMF.

  10. Our results will help understand the mechanism of ETV4 (show ETV4 Proteins) overexpression in CRC patients and provide a clue to search new therapeutic target to treat the related tumors in clinical practice.

Pig (Porcine) Mitogen-Activated Protein Kinase 1 (MAPK1) interaction partners

  1. Agonist stimulation of vascular smooth muscle increases PKC (show FYN Proteins) activity, which, in turn, increases MKP-1 (show DUSP1 Proteins) activity and maintains MAPK1 activity at submaximal values.

  2. sub-vasomotor concentration of ET-1 (show EDN1 Proteins) leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (show MAPK14 Proteins) kinase-mediated production of superoxide from NADPH oxidase (show NOX1 Proteins) following ETA receptor activation

  3. Treatment with ERK inhibitors or ERK1/2 knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.

  4. This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior.

  5. CSF2 (show CSF2 Proteins) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK-dependent MTOR (show FRAP1 Proteins) signal transduction cascades.

  6. PGRN (show GRN Proteins) inhibits adipogenesis in porcine preadipocytes partially through ERK activation mediated PPARgamma (show PPARG Proteins) phosphorylation.

  7. Data show that proinflammatory cytokines induction was ERK1/2 and JNK1 (show MAPK8 Proteins)/2 dependent.

  8. The authors show that porcine circovirus type 2 (PCV2) activates ERK1/2 in PCV2-infected PK15 cells dependent on viral replication.

  9. 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.

  10. Data show that treatment with GH or IGF-I (show IGF1 Proteins) reduced leptin receptor (show LEPR Proteins) expression, and increased Phosphorylation of ERK1/2 in response to acute leptin (show LEP Proteins).

Xenopus laevis Mitogen-Activated Protein Kinase 1 (MAPK1) interaction partners

  1. The reciprocal feedback observed between MPF (show MSLN Proteins) and ERK2 in meiosis is not observed during mitotic M-phase in cell-free Xenopus embryo extracts.

ERK2 (MAPK1) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

Alternative names and synonyms associated with ERK2 (MAPK1)

  • mitogen-activated protein kinase 1 (ATMPK1)
  • mitogen-activated protein kinase 1 (MPK1)
  • mitogen-activated protein kinase 2 (MPK2)
  • mitogen-activated protein kinase 1 (MAPK1)
  • mitogen-activated protein kinase 1 (mapk1)
  • mitogen-activated protein kinase 1 (Mapk1)
  • mitogen-activated protein kinase 1 (PfMAP1)
  • mitogen-activated protein kinase 1 (PVX_084965)
  • mitogen activated protein kinase 1 (Mapk1)
  • mitogen-activated protein kinase 1 (Tsp_01601)
  • mitogen-activated protein kinase 1 (mapk1-b)
  • mitogen-activated protein kinase 1 (mapk1-a)
  • 9030612K14Rik protein
  • AA407128 protein
  • ATMPK1 protein
  • ATMPK2 protein
  • AU018647 protein
  • C78273 protein
  • erk protein
  • erk2 protein
  • ert1 protein
  • F14N23.9 protein
  • F14N23_9 protein
  • mapk protein
  • mapk1 protein
  • mapk1a protein
  • mapk1b protein
  • mapk2 protein
  • MITOGEN-ACTIVATED PROTEIN KINASE protein
  • mitogen-activated protein kinase 1 protein
  • mitogen-activated protein kinase homolog 2 protein
  • mpk1 protein
  • p38 protein
  • p40 protein
  • p41 protein
  • p41mapk protein
  • p42mapk protein
  • prkm1 protein
  • prkm2 protein
  • T30E16.13 protein
  • T30E16_13 protein
  • Xp42 protein
  • zERK2 protein

Protein level used designations for MAPK1

mitogen-activated protein kinase 1 , ERK-2 , ERT1 , MAP kinase 1 , MAP kinase 2 , MAPK 1 , MAPK 2 , extracellular signal-regulated kinase 2 , mitogen-activated protein kinase 2 , p42-MAPK , ERK2 , MAP kinase isoform p42 , protein tyrosine kinase ERK2 , mitogen activated protein kinase 1 , extracellular-signal-regulated kinase 2 , extracellular signal-regulated kinase-2 , MAP kinase , mitogen-activated protein kinase 1b , myelin basic protein kinase-like protein , mitogen-activated protein kinase 1a

GENE ID SPECIES
9328617 Arabidopsis lyrata subsp. lyrata
837559 Arabidopsis thaliana
842248 Arabidopsis thaliana
327672 Bos taurus
477575 Canis lupus familiaris
360144 Danio rerio
373953 Gallus gallus
5594 Homo sapiens
26413 Mus musculus
811876 Plasmodium falciparum 3D7
5475967 Plasmodium vivax Sal-1
116590 Rattus norvegicus
100153927 Sus scrofa
10911653 Trichinella spiralis
549881 Xenopus (Silurana) tropicalis
397785 Xenopus laevis
398985 Xenopus laevis
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