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Browse our ERK2 Proteins (MAPK1)

Full name:
Mitogen-Activated Protein Kinase 1 Proteins (MAPK1)
On www.antibodies-online.com are 36 Mitogen-Activated Protein Kinase 1 (MAPK1) Proteins from 13 different suppliers available. Additionally we are shipping ERK2 Antibodies (347) and ERK2 Kits (45) and many more products for this protein. A total of 444 ERK2 products are currently listed.
Synonyms:
9030612K14Rik, AA407128, ATMPK1, ATMPK2, AU018647, C78273, erk, erk2, ert1, F14N23.9, F14N23_9, mapk, mapk1, mapk1a, mapk1b, mapk2, MITOGEN-ACTIVATED PROTEIN KINASE, mitogen-activated protein kinase 1, mitogen-activated protein kinase homolog 2, mpk1, p38, p40, p41, p41mapk, p42mapk, prkm1, prkm2, T30E16.13, T30E16_13, Xp42, zERK2
list all proteins Gene Name GeneID UniProt
MAPK1 5594 P28482
MAPK1 26413 P63085
MAPK1 116590 P63086

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ERK2 Proteins (MAPK1) by Origin

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Top referenced ERK2 Proteins

  1. Human ERK2 Protein expressed in Baculovirus infected Insect Cells - ABIN2001936 : Slack, Seternes, Gabrielsen, Keyse: Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1. in The Journal of biological chemistry 2001 (PubMed)
    Show all 2 references for ABIN2001936

  2. Human ERK2 Protein expressed in Escherichia coli (E. coli) - ABIN666923 : Hu, Xie, Onishi, Yu, Jiang, Lin, Rho, Woodard, Wang, Jeong, Long, He, Wade, Blackshaw, Qian, Zhu: Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling. in Cell 2009 (PubMed)
    Show all 2 references for ABIN666923

More Proteins for ERK2 Interaction Partners

Arabidopsis thaliana Mitogen-Activated Protein Kinase 1 (MAPK1) interaction partners

  1. MKP1 (show DUSP1 Proteins) is a negative regulator of signaling pathways required for some, but not all, early and late pathogen-associated molecular pattern responses.

  2. MKP1 (show DUSP1 Proteins) and PTP1 act redundantly to suppress salicylic acid and camalexin biosynthesis, and regulate growth homeostasis and PR gene expression in an MPK3 (show MAPK3 Proteins)- and MPK6 (show MAPK6 Proteins)-dependent manner.

  3. Regulation of AtMPK1/2 kinase activity in Arabidopsis might be under the control of signals involved in different kinds of stress.

  4. AtMKP2, a novel MKP protein in Arabidopsis, acts upon MPK3 (show MAPK3 Proteins) and -6, and serves as a positive regulator of the cellular response to oxidant challenge

Cow (Bovine) Mitogen-Activated Protein Kinase 1 (MAPK1) interaction partners

  1. The present results suggest that demecolcine might contribute to the activation of the Mos (show MOCOS Proteins)/MAPK pathway and affect spindle structure

  2. MAPK1 upregulated milk protein (show CSN2 Proteins) synthesis through the Stat5 (show STAT5A Proteins) and mTOR (show FRAP1 Proteins) pathways.

  3. Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.

  4. ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation.

  5. Cyclin-dependent kinase (show CDK1 Proteins) inhibition did not affect the expression (mRNA and protein levels) and localization of maturation promoting factor(MPF (show MSLN Proteins)) and MAPK, and had nearly no effect on kinase activities during maturation.

  6. Thrombospondin 1 (show THBS1 Proteins), fibronectin (show FN1 Proteins), and vitronectin (show VTN Proteins) are differentially dependent upon RAS, ERK1/2, and p38 (show MAPK14 Proteins) for induction of vascular smooth muscle cell chemotaxis.

  7. results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation

  8. These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 (show EGR1 Proteins) nuclear accumulation.

  9. Role of CaMKII (show CAMK2G Proteins) in hydrogen peroxide activation of p38 MAPK (show MAPK14 Proteins)/heat shock protein 27 pathway and ERK1/2

  10. data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.

Zebrafish Mitogen-Activated Protein Kinase 1 (MAPK1) interaction partners

  1. Excess PLAC8 promotes an unconventional ERK2-dependent EMT (show ITK Proteins) in colon cancer.

  2. ERK1/2-Akt1 (show AKT1 Proteins) crosstalk regulates arteriogenesis in mice and zebrafish.

  3. eena (show SH3GL1 Proteins) plays an important role in the development of the myeloid cell through activation of the ERK1 (show MAPK3 Proteins)/ERK2 pathway

  4. ERK1 (show MAPK3 Proteins) and ERK2 target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK2 genes involved in cell-migration, mesendoderm differentiation and patterning were identified.

  5. These results demonstrate that induction of Hsp70 (show HSPA1A Proteins) in response to heat stress is dependent on ERK activation in Pac2 (show PSMG2 Proteins) cells.

  6. Data define distinct roles for ERK1 (show MAPK3 Proteins) and ERK2 in developmental cell migration processes during zebrafish embryogenesis.

Human Mitogen-Activated Protein Kinase 1 (MAPK1) interaction partners

  1. ERK1 and ERK2 interact with Gab2 via a novel docking motif, which is required for subsequent Gab2 phosphorylation in response to ERK1/2 activation.

  2. p38MAPK (show MAPK14 Proteins)-hyaluronan-dependent reprogramming of the tumor microenvironment plays a critical role in driving lung tumorigenesis.

  3. ER-alpha36 is localized on the plasma membrane and cytoplasm in both cervical cancer tissues and cell lines. ER-alpha36 mediates estrogen-stimulated MAPK/ERK activation and regulates migration, invasion, proliferation in cervical cancer cells.

  4. By simulating therapeutic strategies that target multiple nodes of the pathway such as Raf and SphK1, we conclude that combination therapy should be much more effective in blocking VEGF signaling to EKR1/2. The model has important implications for interventions that target signaling pathways in angiogenesis relevant to cancer, vascular diseases, and wound healing.

  5. MicroRNA-329-3p targets MAPK1 (show MAPK3 Proteins) to suppress cell proliferation, migration and invasion in cervical cancer.

  6. urthermore, MAPK signaling may control the expression of PD-L1 (show CD274 Proteins) and several genes related to enhanced cell motility. Our findings suggest that MAPK, along with STAT3 (show STAT3 Proteins), is important for determining PD-L1 (show CD274 Proteins) expression, which could be useful for targeted therapies against lung cancers.

  7. OPN (show SPP1 Proteins) is involved in HCT116 cell progression and is capable of inhibiting cell autophagy possibly by activating the p38 MAPK (show MAPK14 Proteins) signaling pathway

  8. Taken together we show that FBXO25 functions as a negative regulator of MAPK signaling though the reduction of ERK1/2 activation.

  9. IQ domain of IQGAP1 is both necessary and sufficient for binding to ERK1 (show MAPK3 Proteins) and ERK2, as well as to the MAPK kinases MEK1 (show MAP2K1 Proteins) and MEK2 (show MAP2K2 Proteins).

  10. The results suggest that Sirt2 (show SIRT2 Proteins) plays a crucial role in neuronal differentiation via the ERK (show EPHB2 Proteins)-CREB (show CREB1 Proteins) signaling pathway.

Mouse (Murine) Mitogen-Activated Protein Kinase 1 (MAPK1) interaction partners

  1. Low frequency pulsed electromagnetic field (PEMF) induced the activation of extracellular signal-regulated kinases ERK1/2, and the phosphorylation level of ERK1/2 increased after 15 min when exposed to PEMF.

  2. Our results will help understand the mechanism of ETV4 (show ETV4 Proteins) overexpression in CRC patients and provide a clue to search new therapeutic target to treat the related tumors in clinical practice.

  3. A- and B-Raf ablation in chondrocytes does not alter skeletal development, whereas ablation of C-Raf decreases hypertrophic chondrocyte apoptosis and impairs vascularization of the growth plate. However, ablation of C-Raf does not impair phosphate-induced ERK1/2 phosphorylation in vitro, but leads to rickets by decreasing VEGF protein stability.

  4. PDGFbetaR was expressed and hyperphosphorylated in the majority of tumour samples and tumour derived cell lines. Additionally, both MEK (show MDK Proteins) and ERK (show EPHB2 Proteins) were expressed and activated in cell lines as well as biopsies.

  5. In conclusion, the present study demonstrated that EA can suppress osteoclastogenesis in vitro. Moreover, we clarified that these inhibitory effects of EA occur through suppression of NF-kappaB (show NFKB1 Proteins) and ERK (show EPHB2 Proteins) activation. Therefore, EA may be a potential agent in the treatment of osteoclast-related diseases such as osteoporosis.

  6. HSP27 (show HSPB1 Proteins) expression is upregulated in lung fibroblasts during pulmonary fibrosis, and subsequently, HSP27 (show HSPB1 Proteins) modulates lung fibroblast differentiation through the Smad3 (show SMAD3 Proteins) and ERK (show EPHB2 Proteins) pathways.

  7. Neuroprotective effects of oleoylethanolamide on cerebral ischemia may be attributed to its antiapoptotic property achieved, at least in part, through the PPARalpha signaling and inhibition of both TLR4/NF-kappaB and ERK1/2 signaling pathways.

  8. These results indicated that the activation of the ERK1/2 signal transduction pathway may have an important role in glucosestimulated insulin (show INS Proteins) secretion in betaTC6 cells.

  9. Anxa5 (show ANXA5 Proteins) mediates the in vitro malignant behaviours of murine hepatocarcinoma Hca-F cells via ERK2/c-Jun (show JUN Proteins)/p-c-Jun (show JUN Proteins)(Ser73) and ERK2/E-cadherin (show CDH1 Proteins) pathways.

  10. PI3K, MAPK/ERK 1 (show MAPK3 Proteins)/2, and p38 (show CRK Proteins)-signaling proteins are not the main regulators of local production of erythropoietin (show EPO Proteins) after 30% loss of circulating blood volume.

Pig (Porcine) Mitogen-Activated Protein Kinase 1 (MAPK1) interaction partners

  1. Agonist stimulation of vascular smooth muscle increases PKC (show FYN Proteins) activity, which, in turn, increases MKP-1 (show DUSP1 Proteins) activity and maintains MAPK1 activity at submaximal values.

  2. sub-vasomotor concentration of ET-1 (show EDN1 Proteins) leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (show MAPK14 Proteins) kinase-mediated production of superoxide from NADPH oxidase (show NOX1 Proteins) following ETA receptor activation

  3. Treatment with ERK inhibitors or ERK1/2 knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.

  4. This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior.

  5. CSF2 (show CSF2 Proteins) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK-dependent MTOR (show FRAP1 Proteins) signal transduction cascades.

  6. PGRN (show GRN Proteins) inhibits adipogenesis in porcine preadipocytes partially through ERK activation mediated PPARgamma (show PPARG Proteins) phosphorylation.

  7. Data show that proinflammatory cytokines induction was ERK1/2 and JNK1 (show MAPK8 Proteins)/2 dependent.

  8. The authors show that porcine circovirus type 2 (PCV2) activates ERK1/2 in PCV2-infected PK15 cells dependent on viral replication.

  9. 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.

  10. Data show that treatment with GH or IGF-I (show IGF1 Proteins) reduced leptin receptor (show LEPR Proteins) expression, and increased Phosphorylation of ERK1/2 in response to acute leptin (show LEP Proteins).

Xenopus laevis Mitogen-Activated Protein Kinase 1 (MAPK1) interaction partners

  1. The reciprocal feedback observed between MPF (show MSLN Proteins) and ERK2 in meiosis is not observed during mitotic M-phase in cell-free Xenopus embryo extracts.

ERK2 (MAPK1) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

Alternative names and synonyms associated with ERK2 (MAPK1)

  • mitogen-activated protein kinase 1 (ATMPK1)
  • mitogen-activated protein kinase 1 (MPK1)
  • mitogen-activated protein kinase 2 (MPK2)
  • mitogen-activated protein kinase 1 (MAPK1)
  • mitogen-activated protein kinase 1 (mapk1)
  • mitogen-activated protein kinase 1 (Mapk1)
  • mitogen-activated protein kinase 1 (PfMAP1)
  • mitogen-activated protein kinase 1 (PVX_084965)
  • mitogen activated protein kinase 1 (Mapk1)
  • mitogen-activated protein kinase 1 (Tsp_01601)
  • mitogen-activated protein kinase 1 (mapk1-b)
  • mitogen-activated protein kinase 1 (mapk1-a)
  • 9030612K14Rik protein
  • AA407128 protein
  • ATMPK1 protein
  • ATMPK2 protein
  • AU018647 protein
  • C78273 protein
  • erk protein
  • erk2 protein
  • ert1 protein
  • F14N23.9 protein
  • F14N23_9 protein
  • mapk protein
  • mapk1 protein
  • mapk1a protein
  • mapk1b protein
  • mapk2 protein
  • MITOGEN-ACTIVATED PROTEIN KINASE protein
  • mitogen-activated protein kinase 1 protein
  • mitogen-activated protein kinase homolog 2 protein
  • mpk1 protein
  • p38 protein
  • p40 protein
  • p41 protein
  • p41mapk protein
  • p42mapk protein
  • prkm1 protein
  • prkm2 protein
  • T30E16.13 protein
  • T30E16_13 protein
  • Xp42 protein
  • zERK2 protein

Protein level used designations for MAPK1

mitogen-activated protein kinase 1 , ERK-2 , ERT1 , MAP kinase 1 , MAP kinase 2 , MAPK 1 , MAPK 2 , extracellular signal-regulated kinase 2 , mitogen-activated protein kinase 2 , p42-MAPK , ERK2 , MAP kinase isoform p42 , protein tyrosine kinase ERK2 , mitogen activated protein kinase 1 , extracellular-signal-regulated kinase 2 , extracellular signal-regulated kinase-2 , MAP kinase , mitogen-activated protein kinase 1b , myelin basic protein kinase-like protein , mitogen-activated protein kinase 1a

GENE ID SPECIES
9328617 Arabidopsis lyrata subsp. lyrata
837559 Arabidopsis thaliana
842248 Arabidopsis thaliana
327672 Bos taurus
477575 Canis lupus familiaris
360144 Danio rerio
373953 Gallus gallus
5594 Homo sapiens
26413 Mus musculus
811876 Plasmodium falciparum 3D7
5475967 Plasmodium vivax Sal-1
116590 Rattus norvegicus
100153927 Sus scrofa
10911653 Trichinella spiralis
549881 Xenopus (Silurana) tropicalis
397785 Xenopus laevis
398985 Xenopus laevis
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