Gap junction alpha-1 protein (connexin-43) is a transmembrane channel that, together with other connexins, forms a gap junction. Gap junctions allow low MW materials to flow from one cell to a neighboring cell. Defects in connexin-43 are the cause of autosomal dominant oculodentodigital dysplasia (ODDD), also known as oculodentoosseous dysplasia. ODDD is a highly penetrant syndrome presenting with craniofacial (ocular, nasal, dental) and limb dysmorphisms, spastic paraplegia, and neurodegeneration.
Each vial contains 0.1 mg IgG in 0.1 mL of PBS pH7.4, 50% glycerol with 0.09% sodium azide.
Precaution of Use
Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.