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anti-Rat (Rattus) Glucokinase Antibodies:
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This report details the first structure of GLK; comparison of its activation loop sequence and P-loop structure to that of Map4k4 (show MAP4K4 Antibodies) suggests ideas for designing inhibitors that can distinguish between these family members to achieve selective pharmacological inhibitors.
ITGB3 (show ITGB3 Antibodies) and MAP4K3 (show MAP4K3 Antibodies) are directly repressed by let-7c, altering the metastatic potential of lung cancer cells.
MAP4K3 (show MAP4K3 Antibodies) expression is required for leucine-induced mTORC1 activation in human primary fibroblasts.
Significantly higher median frequencies of circulating GLK-expressing T-cells were observed in patients with adult-onset Still's disease (31.85%) than in healthy volunteers (8.93%, P <0.001).
Amino acid sufficiency phosphorylates MAP4K3 (show MAP4K3 Antibodies)/Ser170, activating mTORC1, but amino acid restriction causes MAP4K3 (show MAP4K3 Antibodies) to interact with PP2A (show PPP2R4 Antibodies)(T61 epsilon), promoting dephosphorylation of Ser170, MAP4K3 (show MAP4K3 Antibodies) inhibition, and, inhibition of mTORC1 signaling.
MAP4K3 (show MAP4K3 Antibodies) orchestrates activation of BAX (show BAX Antibodies) via the concerted posttranscriptional modulation of PUMA (show BBC3 Antibodies), BAD, and BIM (show BCL2L11 Antibodies).
This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.
, MAPK/ERK kinase kinase kinase 3
, MEK kinase kinase 3
, MEKKK 3
, germinal center kinase-related protein kinase
, germinal center kinase-like kinase