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Browse our anti-JNK (MAPK8) Antibodies

Full name:
anti-Mitogen-Activated Protein Kinase 8 Antibodies (MAPK8)
On www.antibodies-online.com are 398 Mitogen-Activated Protein Kinase 8 (MAPK8) Antibodies from 32 different suppliers available. Additionally we are shipping JNK Proteins (24) and JNK Kits (18) and many more products for this protein. A total of 474 JNK products are currently listed.
Synonyms:
AI849689, Bsk, BSK/DJNK, c-Jun, CG5680, D-JNK, D-junk, DBSK/JNK, dJNK, DJNK/bsk, Dmel\\CG5680, jnk, JNK-46, JNK/SAPK, jnk1, JNK1A2, JNK21B1/2, Junk, mapk8, Prkm8, sapk1, SAPK1c, SAPKa, T10F20.15, zgc:112379
list all antibodies Gene Name GeneID UniProt
MAPK8 5599 P45983
MAPK8 26419 Q91Y86
MAPK8 116554 P49185

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All available anti-JNK Antibodies

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Top referenced anti-JNK Antibodies

  1. Human Monoclonal JNK Primary Antibody for IP, WB - ABIN967329 : Adler, Fuchs, Kim, Kraft, King, Pelling, Ronai: jun-NH2-terminal kinase activation mediated by UV-induced DNA lesions in melanoma and fibroblast cells. in Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996 (PubMed)
    Show all 8 references for ABIN967329

  2. Human Polyclonal JNK Primary Antibody for IF, IHC (p) - ABIN391724 : Deng, Ren, Yang, Lin, Wu: A JNK-dependent pathway is required for TNFalpha-induced apoptosis. in Cell 2003 (PubMed)
    Show all 6 references for ABIN391724

  3. Human Polyclonal JNK Primary Antibody for EIA - ABIN358374 : Luo, Ng, Jin, Ye, Han, Lin: Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation. in The Journal of biological chemistry 2003 (PubMed)
    Show all 5 references for ABIN358374

  4. Human Polyclonal JNK Primary Antibody for EIA, WB - ABIN359636 : Ghosh: Inhibition of arachidonate 5-lipoxygenase triggers prostate cancer cell death through rapid activation of c-Jun N-terminal kinase. in Biochemical and biophysical research communications 2003 (PubMed)
    Show all 5 references for ABIN359636

  5. Human Polyclonal JNK Primary Antibody for EIA, IHC (p) - ABIN953314 : Dasgupta, Kar, Liu, Joseph, Kalyanaraman, Remington, Chen, Melendez: Reactive oxygen species control senescence-associated matrix metalloproteinase-1 through c-Jun-N-terminal kinase. in Journal of cellular physiology 2010 (PubMed)
    Show all 5 references for ABIN953314

  6. Cow (Bovine) Polyclonal JNK Primary Antibody for IF (p), IHC (p) - ABIN732368 : Rosenzweig, Djap, Ou, Quinn: Mechanical injury of bovine cartilage explants induces depth-dependent, transient changes in MAP kinase activity associated with apoptosis. in Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2012 (PubMed)
    Show all 4 references for ABIN732368

  7. Human Monoclonal JNK Primary Antibody for FACS, WB - ABIN968866 : Fleming, Armstrong, Morrice, Paterson, Goedert, Cohen: Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7. in The Biochemical journal 2001 (PubMed)
    Show all 4 references for ABIN968866

  8. Human Polyclonal JNK Primary Antibody for IHC (p), WB - ABIN654887 : Han, Crowe: Jun amino-terminal kinase 1 activation promotes cell survival in ErbB2-positive breast cancer. in Anticancer research 2010 (PubMed)
    Show all 3 references for ABIN654887

  9. Human Polyclonal JNK Primary Antibody for IF (p), IHC (p) - ABIN747713 : Li, Qiu, Lin, He, Hua, Yuan, Liu, Wei: c-Jun N-terminal kinase is upregulated in patients with hypospadias. in Urology 2012 (PubMed)

  10. Human Monoclonal JNK Primary Antibody for WB - ABIN2452243 : Sung, Liang, Lee, Yen, Hsiao, Wang, Jiang-Shieh, Tsai, Chen: The protective effect of eupafolin against TNF-?-induced lung inflammation via the reduction of intercellular cell adhesion molecule-1 expression. in Journal of ethnopharmacology 2015 (PubMed)

More Antibodies against JNK Interaction Partners

Fruit Fly (Drosophila melanogaster) Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. malignant transformation of the ras(V12)scrib(1 (show SCRIB Antibodies)) tumors requires bZIP protein Fos, the ETS (show ETS1 Antibodies)-domain factor Ets21c and the nuclear receptor Ftz-F1 (show NR5A2 Antibodies), all acting downstream of Jun-N-terminal kinase.

  2. Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction.

  3. ROS (show ROS1 Antibodies)/JNK/p38 (show MAPK14 Antibodies)/Upd (show UROD Antibodies) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.

  4. Significantly, the JNK pathway is responsible for the majority of the phenotypes and transcriptional changes downstream of Notch (show NOTCH1 Antibodies)-Src (show SRC Antibodies) synergy.

  5. This study demonstrated that the mechanism by which Bsk (show FRK Antibodies) is required for pruning is through reducing the membrane levels of the adhesion molecule (show NCAM1 Antibodies) Fasciclin II (show NCAM2 Antibodies) (FasII)

  6. Study solves the crystal structure of unphosphorylated DJNK in complex with adenylyl imidodiphosphate (AMP (show AMPH Antibodies)-PNP (show NP Antibodies)) and magnesium.

  7. PERK/ATF4 activated the JNK pathway through Rac1 and Slpr activation in apoptotic cells.

  8. Data show that oxidative stress and neuroinflammation are intrinsic components of TDP-43 (show TARDBP Antibodies)-associated neurodegeneration and the balance between cytoprotective JNK and cytotoxic p38 (show MAPK14 Antibodies) signaling dictates phenotypic outcome to TDP-43 (show TARDBP Antibodies) expression in Drosophila.

  9. Data show that the actin-Capping Protein (show TMOD4 Antibodies) (CP) alphabeta heterodimer, which regulates actin (show ACTB Antibodies) filament (F-actin (show ACTB Antibodies)) polymerization, limits Src (show SRC Antibodies)-induced apoptosis or tissue overgrowth by restricting JNK activation.

  10. In a genetic screen, we identified signaling by the EGFR (show EGFR Antibodies) pathway as important for apoptosis-induced proliferation acting downstream of JNK signaling

Human Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. JNK/c-Jun activation and BIM (show BCL2L11 Antibodies) induction is a late pro-apoptotic response of glioma cells treated with alkylating anticancer drugs.

  2. Phloretin is able to inhibit NSCLC A549 cell growth by inducing apoptosis through P38 MAPK (show MAPK14 Antibodies) and JNK1/2 pathways, and therefore may prove to be an adjuvant to the treatment of non-small cell lung cancer

  3. The crystal structure of JNK1 bound to the catalytic domain of MKP7 (show DUSP16 Antibodies) at 2.4-A resolution, providing high-resolution structural insight into the FXF-docking interaction, is reported.

  4. Data show that caspase recruitment domain-containing protein 11 (show CARD11 Antibodies)/B-cell CLL/lymphoma 10 (show BCL10 Antibodies)/mucosa-associated lymphoid tissue lymphoma translocation gene 1 (show MALT1 Antibodies) signaling drives lymphoproliferation (show FAS Antibodies) through NF-kappa B (show NFKB1 Antibodies) and c-Jun N-terminal kinase activation.

  5. These results suggest that ITCs could be potential agents for the prevention of C6 glioma cell migration and invasion by decreasing FAK (show PTK2 Antibodies)/JNK-mediated MMP-9 (show MMP9 Antibodies) expression

  6. In hepatocytes, JNK1 and JNK2 (show MAPK9 Antibodies) appear to have combined effects in protecting from drug-induced liver injury.

  7. H/R activates ROS (show ROS1 Antibodies)/Egr-1 (show EGR1 Antibodies) signaling pathway in H9c2 cells, and JNK activation plays an important role in this pathway

  8. Inhibition of JNK1/2 activity suppressed Hedgehog (show SHH Antibodies) pathway activity in acquired chemoresistant cancer cells.

  9. MAPK8-mediated stabilization of SP1 (show PSG1 Antibodies) is essential for RUNX1 (show RUNX1 Antibodies)-RUNX1T1 (show RUNX1T1 Antibodies) - driven leukaemia.

  10. cAMP signaling increases HDAC8 (show HDAC8 Antibodies) protein levels by reducing JNK-mediated autophagy and ubiquitin-proteasome-dependent degradation of the HDAC8 (show HDAC8 Antibodies) protein in H1299 lung cancer cells.

Mouse (Murine) Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. Reactive oxygen species induce autophagy to counteract apoptosis in mesenchymal stem cells by activation of JNK.

  2. In hepatocytes, JNK1 and JNK2 (show MAPK9 Antibodies) appear to have combined effects in protecting from drug-induced liver injury.

  3. The findings suggest that JNK and P38 (show CRK Antibodies) could be key regulatory element for Fam83h (show FAM83H Antibodies) expression, and that LS8 cells can respond to fluoride by down-regulating Fam83h (show FAM83H Antibodies) expression through the regulation of JNK and p38 (show CRK Antibodies) signaling pathways.

  4. Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction.

  5. Role of JNK in the pathophysiology of hemorrhage/resususcitation-induced liver injury after chronic ethanol feeding

  6. Taken together, our findings demonstrate that salicortin inhibits NF-kappaB (show NFKB1 Antibodies) and NFATc1 (show NFATC1 Antibodies) activation, leading to attenuation of osteoclastogenesis and bone resorption.

  7. Rotavirus infection in macrophages depend on MAVS (show MAVS Antibodies) but not involve the NLRP3 (show NLRP3 Antibodies) inflammasome nor JNK and p38 (show CRK Antibodies) signal pathway.

  8. results suggest that JNK is a major negative regulator in mAChR (show CHRM3 Antibodies)-induced intestinal secretion.

  9. although JNK activation and RIP3 (show MPRIP Antibodies) expression are induced by FS, neither contributes to the liver injury.

  10. A possible mechanism by which tomoregulin-1 (show TMEFF1 Antibodies) regulates the development of cardiac hypertrophy in TAC (show IL2RA Antibodies)-induced cardiac hypertrophy is through inhibiting TGFbeta (show TGFB1 Antibodies) non-canonical (TAK1 (show NR2C2 Antibodies)-JNK) pathways in the myocardium.

Xenopus laevis Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3 (show CASP3 Antibodies)-dependent Proteolysis of JNK1-2 and Bid (show BID Antibodies).

  2. JNK signaling is required to establish microtubule stability and maintain tissue cohesion in the gut (show GUSB Antibodies).

  3. Data show that the death pathway is independent of ERK (show MAPK1 Antibodies) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (show CDK1 Antibodies) and JNK.

Arabidopsis thaliana Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. study reports MPK8 connects protein phosphorylation, Ca(2 (show CA2 Antibodies))+ and ROS (show ROS1 Antibodies) in wound-signaling pathway; suggests 2 major activation modes, Ca(2 (show CA2 Antibodies))+/CaMs and MAP kinase (show MAPK1 Antibodies) phosphorylation cascade, converge at MPK8 to monitor or maintain an essential part of ROS (show ROS1 Antibodies) homeostasis

Zebrafish Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein

  2. P38 (show MAPK14 Antibodies) and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.

  3. A dorsalization pathway that is exerted by Axin (show AXIN1 Antibodies)/JNK signaling and its inhibitor Aida (show AIDA Antibodies) during vertebrate embryogenesis, is defined.

  4. JNK-Mmp13 (show MMP13 Antibodies) signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo

Caenorhabditis elegans (C. elegans) Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. JNK-1 directly interacts with and phosphorylates DAF-16. Moreover, in response to heat stress, JNK-1 promotes the translocation of DAF-16 into the nucleus.

  2. The present study shows in Caenorhabditis elegans that ambient temperature (1-37 degrees C) specifically influences the activation (phosphorylation) of the MAP kinase JNK-1 as well as the nuclear translocation of DAF-16.

  3. the stress response is controlled by a c-Jun N-terminal kinase (JNK)-like mitogen-activated protein kinase (show MAPK1 Antibodies) (MAPK (show MAPK1 Antibodies)) signaling pathway, which is regulated by MLK-1 (show MAP3K9 Antibodies) MAPK (show MAPK1 Antibodies) kinase kinase (MAPKKK), MEK-1 (show MAP2K1 Antibodies) MAPK (show MAPK1 Antibodies) kinase (MAPKK), and KGB-1 (show KCNJ3 Antibodies) JNK-like MAPK (show MAPK1 Antibodies).

JNK (MAPK8) Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Alternative names and synonyms associated with JNK (MAPK8)

  • basket (bsk) antibody
  • mitogen-activated protein kinase 8 (MAPK8) antibody
  • mitogen-activated protein kinase 8 (Mapk8) antibody
  • mitogen-activated protein kinase 8 (mapk8) antibody
  • mitogen-activated protein kinase 8 (ATMPK8) antibody
  • mitogen-activated protein kinase 8b (mapk8b) antibody
  • Protein JNK-1 (jnk-1) antibody
  • AI849689 antibody
  • Bsk antibody
  • BSK/DJNK antibody
  • c-Jun antibody
  • CG5680 antibody
  • D-JNK antibody
  • D-junk antibody
  • DBSK/JNK antibody
  • dJNK antibody
  • DJNK/bsk antibody
  • Dmel\\CG5680 antibody
  • jnk antibody
  • JNK-46 antibody
  • JNK/SAPK antibody
  • jnk1 antibody
  • JNK1A2 antibody
  • JNK21B1/2 antibody
  • Junk antibody
  • mapk8 antibody
  • Prkm8 antibody
  • sapk1 antibody
  • SAPK1c antibody
  • SAPKa antibody
  • T10F20.15 antibody
  • zgc:112379 antibody

Protein level used designations for MAPK8

CG5680-PB , CG5680-PE , CG5680-PF , JNK , JUN kinase , Jun N-terminal kinase , Jun NH2-terminal kinase , Jun-N-terminal kinase , Jun-kinase , bsk-PB , bsk-PE , bsk-PF , c-Jun N-terminal kinase , c-Jun aminoterminal kinase , c-Jun-N-terminal kinase , drosophila JNK , JUN N-terminal kinase , MAP kinase 8 , c-Jun N-terminal kinase 1 , mitogen-activated protein kinase 8 isoform JNK1 alpha1 , mitogen-activated protein kinase 8 isoform JNK1 beta2 , stress-activated protein kinase 1 , stress-activated protein kinase 1c , JNK1 beta1 protein kinase , MAPK 8 , mitogen activated protein kinase 8 , protein kinase mitogen-activated 8 , stress-activated protein kinase JNK1 , SAPK gamma , c-jun NH2-terminal kinase , p54 gamma , jnk1a-1 , mitogen-activated protein kinase 8

GENE ID SPECIES
44801 Drosophila melanogaster
5599 Homo sapiens
26419 Mus musculus
116554 Rattus norvegicus
379876 Xenopus laevis
838394 Arabidopsis thaliana
65236 Danio rerio
177460 Caenorhabditis elegans
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