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Browse our anti-JNK (MAPK8) Antibodies

Full name:
anti-Mitogen-Activated Protein Kinase 8 Antibodies (MAPK8)
On are 402 Mitogen-Activated Protein Kinase 8 (MAPK8) Antibodies from 33 different suppliers available. Additionally we are shipping JNK Proteins (24) and JNK Kits (21) and many more products for this protein. A total of 479 JNK products are currently listed.
AI849689, Bsk, BSK/DJNK, c-Jun, CG5680, D-JNK, D-junk, DBSK/JNK, dJNK, DJNK/bsk, Dmel\\CG5680, jnk, JNK-46, JNK/SAPK, jnk1, JNK1A2, JNK21B1/2, Junk, mapk8, Prkm8, sapk1, SAPK1c, SAPKa, T10F20.15, zgc:112379
list all antibodies Gene Name GeneID UniProt
MAPK8 5599 P45983
MAPK8 26419 Q91Y86
MAPK8 116554 P49185

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Most Popular Reactivities for anti-JNK (MAPK8) Antibodies

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anti-Human JNK Antibodies:

anti-Mouse (Murine) JNK Antibodies:

anti-Rat (Rattus) JNK Antibodies:

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Top referenced anti-JNK Antibodies

  1. Human Monoclonal JNK Primary Antibody for IP, WB - ABIN967329 : Adler, Fuchs, Kim, Kraft, King, Pelling, Ronai: jun-NH2-terminal kinase activation mediated by UV-induced DNA lesions in melanoma and fibroblast cells. in Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996 (PubMed)
    Show all 8 references for ABIN967329

  2. Human Polyclonal JNK Primary Antibody for IF, IHC (p) - ABIN391724 : Deng, Ren, Yang, Lin, Wu: A JNK-dependent pathway is required for TNFalpha-induced apoptosis. in Cell 2003 (PubMed)
    Show all 6 references for ABIN391724

  3. Human Polyclonal JNK Primary Antibody for EIA, WB - ABIN359636 : Luo, Ng, Jin, Ye, Han, Lin: Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation. in The Journal of biological chemistry 2003 (PubMed)
    Show all 5 references for ABIN359636

  4. Human Polyclonal JNK Primary Antibody for EIA - ABIN358374 : Ghosh: Inhibition of arachidonate 5-lipoxygenase triggers prostate cancer cell death through rapid activation of c-Jun N-terminal kinase. in Biochemical and biophysical research communications 2003 (PubMed)
    Show all 5 references for ABIN358374

  5. Human Polyclonal JNK Primary Antibody for EIA, IHC (p) - ABIN953314 : Dasgupta, Kar, Liu, Joseph, Kalyanaraman, Remington, Chen, Melendez: Reactive oxygen species control senescence-associated matrix metalloproteinase-1 through c-Jun-N-terminal kinase. in Journal of cellular physiology 2010 (PubMed)
    Show all 5 references for ABIN953314

  6. Human Monoclonal JNK Primary Antibody for FACS, WB - ABIN968866 : Fleming, Armstrong, Morrice, Paterson, Goedert, Cohen: Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7. in The Biochemical journal 2001 (PubMed)
    Show all 4 references for ABIN968866

  7. Human Polyclonal JNK Primary Antibody for IF, WB - ABIN401562 : Davis: Signal transduction by the c-Jun N-terminal kinase. in Biochemical Society symposium 1999 (PubMed)
    Show all 3 references for ABIN401562

  8. Human Polyclonal JNK Primary Antibody for IHC (p), WB - ABIN654887 : Han, Crowe: Jun amino-terminal kinase 1 activation promotes cell survival in ErbB2-positive breast cancer. in Anticancer research 2010 (PubMed)
    Show all 3 references for ABIN654887

  9. Caenorhabditis elegans (C. elegans) Polyclonal JNK Primary Antibody for IHC (p), IHC - ABIN151424 : Oh, Mukhopadhyay, Svrzikapa, Jiang, Davis, Tissenbaum: JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. in Proceedings of the National Academy of Sciences of the United States of America 2005 (PubMed)
    Show all 2 references for ABIN151424

  10. Human Monoclonal JNK Primary Antibody for WB - ABIN2452243 : Sung, Liang, Lee, Yen, Hsiao, Wang, Jiang-Shieh, Tsai, Chen: The protective effect of eupafolin against TNF-?-induced lung inflammation via the reduction of intercellular cell adhesion molecule-1 expression. in Journal of ethnopharmacology 2015 (PubMed)

More Antibodies against JNK Interaction Partners

Fruit Fly (Drosophila melanogaster) Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. malignant transformation of the ras(V12)scrib(1 (show SCRIB Antibodies)) tumors requires bZIP protein Fos, the ETS (show ETS1 Antibodies)-domain factor Ets21c and the nuclear receptor Ftz-F1 (show NR5A2 Antibodies), all acting downstream of Jun-N-terminal kinase.

  2. Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction.

  3. ROS (show ROS1 Antibodies)/JNK/p38 (show MAPK14 Antibodies)/Upd (show UROD Antibodies) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.

  4. Significantly, the JNK pathway is responsible for the majority of the phenotypes and transcriptional changes downstream of Notch (show NOTCH1 Antibodies)-Src (show SRC Antibodies) synergy.

  5. This study demonstrated that the mechanism by which Bsk (show FRK Antibodies) is required for pruning is through reducing the membrane levels of the adhesion molecule (show NCAM1 Antibodies) Fasciclin II (show NCAM2 Antibodies) (FasII)

  6. Study solves the crystal structure of unphosphorylated DJNK in complex with adenylyl imidodiphosphate (AMP (show AMPH Antibodies)-PNP (show NP Antibodies)) and magnesium.

  7. PERK/ATF4 activated the JNK pathway through Rac1 and Slpr activation in apoptotic cells.

  8. Data show that oxidative stress and neuroinflammation are intrinsic components of TDP-43 (show TARDBP Antibodies)-associated neurodegeneration and the balance between cytoprotective JNK and cytotoxic p38 (show MAPK14 Antibodies) signaling dictates phenotypic outcome to TDP-43 (show TARDBP Antibodies) expression in Drosophila.

  9. Data show that the actin-Capping Protein (show TMOD4 Antibodies) (CP) alphabeta heterodimer, which regulates actin (show ACTB Antibodies) filament (F-actin (show ACTB Antibodies)) polymerization, limits Src (show SRC Antibodies)-induced apoptosis or tissue overgrowth by restricting JNK activation.

  10. In a genetic screen, we identified signaling by the EGFR (show EGFR Antibodies) pathway as important for apoptosis-induced proliferation acting downstream of JNK signaling

Human Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. MUC1 (show MUC1 Antibodies) promotes hepatocellular carcinoma progression and tumorigenesis and mediates autocrine TGF-b signaling by activating the JNK/AP-1 (show FOSB Antibodies) pathway in hepatocellular carcinoma cells, and makes MUC1 (show MUC1 Antibodies) and JNK as attractive targets for hepatocellular carcinoma therapy.

  2. Allograft tumor assays in mice demonstrate that this mechanism contributes to tumorigenesis driven by mutant IDH1 (show IDH1 Antibodies), a result confirmed by detection of JNK inactivation in human gliomas harboring IDH1 (show IDH1 Antibodies)-R132H mutations.

  3. Pretreatment by IRE1 (show ERN1 Antibodies) agonist tunicamycin or JNK agonist anisomycin attenuated the effect of psoralen on osteoporotic osteoblasts. Psoralen inhibited apoptosis of osteoporotic osteoblasts by regulating IRE1 (show ERN1 Antibodies)-ASK1 (show MAP3K5 Antibodies)-JNK pathway

  4. Therapeutic interventions of potent and selective inhibitors of JNK might provide promising therapeutic approaches for the treatment of OS, and could improve the survival rate and quality of life of OS patients.

  5. the results obtained from RRD (show DHRS4 Antibodies), QPLD, IFD and MD simulations indicated that lead1 might be used as a potent antagonist toward human JNK1 in cancer therapeutics.

  6. Data indicate that STK40 (show STK40 Antibodies) was a direct target of microRNA miR (show MLXIP Antibodies)-130a, and overexpressing miR (show MLXIP Antibodies)-130a significantly upregulated NF-kappaB (show NFKB1 Antibodies) p65 (show GORASP1 Antibodies), SOX9 (show SOX9 Antibodies), JNK and p38MAPK (show MAPK14 Antibodies) proteins.

  7. Results suggest that curcumin induced the apoptosis of retinoblastoma Y79 cells through the activation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (show MAPK14 Antibodies) (MAPK (show MAPK1 Antibodies)) pathways.

  8. These results suggest that ROCK may be important in IL-1 (show IL1A Antibodies)-induced signaling through MKK4 (show MAP2K4 Antibodies) to JNK and the activation of p38 MAPK (show MAPK14 Antibodies).

  9. High JNK1 expression is associated with hepatocellular carcinoma.

  10. Data show that Jun-N-terminal kinase (JNK)/p38 MAPK (show MAPK14 Antibodies) activations are required for signaling pathway underlying the ajoene-induced apoptosis.

Mouse (Murine) Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. activation of astrocyte MMP2 (show MMP2 Antibodies)/JNK1/2 contributes to the pathogenesis of pain hypersensitivity in the complex regional pain syndrome model

  2. JNK1/2-dependent regulation of p66ShcS36 phosphorylation, is reported.

  3. that JNK played roles in nerve regeneration at both early and late phases

  4. Results suggest that activation of JNK in Alzheimer's disease (AD) inhibits insulin (show INS Antibodies) signaling which could lead to a decreased expression of VGLUT1 (show SLC17A7 Antibodies), therefore contributing to the glutamatergic deficit in AD

  5. The cJun (show JUN Antibodies) NH2-terminal kinase contributes to the regulation of hepatic fibroblast growth factor 21 (show FGF21 Antibodies) expression during fasting/feeding cycles.

  6. JNK kinase is critical for mitochondrial function during reperfusion after myocardial ischemia.

  7. Activated JNK promotes mitochondrial dysfunction and acute hepatotoxicity through robust phosphorylation of numerous mitochondrial proteins.

  8. Reactive oxygen species induce autophagy to counteract apoptosis in mesenchymal stem cells by activation of JNK.

  9. In hepatocytes, JNK1 and JNK2 (show MAPK9 Antibodies) appear to have combined effects in protecting from drug-induced liver injury.

  10. The findings suggest that JNK and P38 (show CRK Antibodies) could be key regulatory element for Fam83h (show FAM83H Antibodies) expression, and that LS8 cells can respond to fluoride by down-regulating Fam83h (show FAM83H Antibodies) expression through the regulation of JNK and p38 (show CRK Antibodies) signaling pathways.

Xenopus laevis Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3 (show CASP3 Antibodies)-dependent Proteolysis of JNK1-2 and Bid (show BID Antibodies).

  2. JNK signaling is required to establish microtubule stability and maintain tissue cohesion in the gut (show GUSB Antibodies).

  3. Data show that the death pathway is independent of ERK (show MAPK1 Antibodies) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (show CDK1 Antibodies) and JNK.

Arabidopsis thaliana Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. study reports MPK8 connects protein phosphorylation, Ca(2 (show CA2 Antibodies))+ and ROS (show ROS1 Antibodies) in wound-signaling pathway; suggests 2 major activation modes, Ca(2 (show CA2 Antibodies))+/CaMs and MAP kinase (show MAPK1 Antibodies) phosphorylation cascade, converge at MPK8 to monitor or maintain an essential part of ROS (show ROS1 Antibodies) homeostasis

Zebrafish Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein

  2. P38 (show MAPK14 Antibodies) and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.

  3. A dorsalization pathway that is exerted by Axin (show AXIN1 Antibodies)/JNK signaling and its inhibitor Aida (show AIDA Antibodies) during vertebrate embryogenesis, is defined.

  4. JNK-Mmp13 (show MMP13 Antibodies) signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo

Caenorhabditis elegans (C. elegans) Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. JNK-1 directly interacts with and phosphorylates DAF-16. Moreover, in response to heat stress, JNK-1 promotes the translocation of DAF-16 into the nucleus.

  2. The present study shows in Caenorhabditis elegans that ambient temperature (1-37 degrees C) specifically influences the activation (phosphorylation) of the MAP kinase JNK-1 as well as the nuclear translocation of DAF-16.

  3. the stress response is controlled by a c-Jun N-terminal kinase (JNK)-like mitogen-activated protein kinase (show MAPK1 Antibodies) (MAPK (show MAPK1 Antibodies)) signaling pathway, which is regulated by MLK-1 (show MAP3K9 Antibodies) MAPK (show MAPK1 Antibodies) kinase kinase (MAPKKK), MEK-1 (show MAP2K1 Antibodies) MAPK (show MAPK1 Antibodies) kinase (MAPKK), and KGB-1 (show KCNJ3 Antibodies) JNK-like MAPK (show MAPK1 Antibodies).

JNK (MAPK8) Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Alternative names and synonyms associated with JNK (MAPK8)

  • basket (bsk) antibody
  • mitogen-activated protein kinase 8 (MAPK8) antibody
  • mitogen-activated protein kinase 8 (Mapk8) antibody
  • mitogen-activated protein kinase 8 (mapk8) antibody
  • mitogen-activated protein kinase 8 (ATMPK8) antibody
  • mitogen-activated protein kinase 8b (mapk8b) antibody
  • Protein JNK-1 (jnk-1) antibody
  • AI849689 antibody
  • Bsk antibody
  • BSK/DJNK antibody
  • c-Jun antibody
  • CG5680 antibody
  • D-JNK antibody
  • D-junk antibody
  • DBSK/JNK antibody
  • dJNK antibody
  • DJNK/bsk antibody
  • Dmel\\CG5680 antibody
  • jnk antibody
  • JNK-46 antibody
  • JNK/SAPK antibody
  • jnk1 antibody
  • JNK1A2 antibody
  • JNK21B1/2 antibody
  • Junk antibody
  • mapk8 antibody
  • Prkm8 antibody
  • sapk1 antibody
  • SAPK1c antibody
  • SAPKa antibody
  • T10F20.15 antibody
  • zgc:112379 antibody

Protein level used designations for MAPK8

CG5680-PB , CG5680-PE , CG5680-PF , JNK , JUN kinase , Jun N-terminal kinase , Jun NH2-terminal kinase , Jun-N-terminal kinase , Jun-kinase , bsk-PB , bsk-PE , bsk-PF , c-Jun N-terminal kinase , c-Jun aminoterminal kinase , c-Jun-N-terminal kinase , drosophila JNK , JUN N-terminal kinase , MAP kinase 8 , c-Jun N-terminal kinase 1 , mitogen-activated protein kinase 8 isoform JNK1 alpha1 , mitogen-activated protein kinase 8 isoform JNK1 beta2 , stress-activated protein kinase 1 , stress-activated protein kinase 1c , JNK1 beta1 protein kinase , MAPK 8 , mitogen activated protein kinase 8 , protein kinase mitogen-activated 8 , stress-activated protein kinase JNK1 , SAPK gamma , c-jun NH2-terminal kinase , p54 gamma , jnk1a-1 , mitogen-activated protein kinase 8

44801 Drosophila melanogaster
5599 Homo sapiens
26419 Mus musculus
116554 Rattus norvegicus
379876 Xenopus laevis
838394 Arabidopsis thaliana
65236 Danio rerio
177460 Caenorhabditis elegans
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