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Browse our anti-JNK (MAPK8) Antibodies

Full name:
anti-Mitogen-Activated Protein Kinase 8 Antibodies (MAPK8)
On www.antibodies-online.com are 395 Mitogen-Activated Protein Kinase 8 (MAPK8) Antibodies from 34 different suppliers available. Additionally we are shipping JNK Proteins (25) and JNK Kits (23) and many more products for this protein. A total of 476 JNK products are currently listed.
Synonyms:
AI849689, Bsk, BSK/DJNK, c-Jun, CG5680, D-JNK, D-junk, DBSK/JNK, dJNK, DJNK/bsk, Dmel\\CG5680, jnk, JNK-46, JNK/SAPK, jnk1, JNK1A2, JNK21B1/2, Junk, mapk8, Prkm8, sapk1, SAPK1c, SAPKa, T10F20.15, zgc:112379
list all antibodies Gene Name GeneID UniProt
MAPK8 5599 P45983
MAPK8 26419 Q91Y86
MAPK8 116554 P49185

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Most Popular Reactivities for anti-JNK (MAPK8) Antibodies

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anti-Human JNK Antibodies:

anti-Mouse (Murine) JNK Antibodies:

anti-Rat (Rattus) JNK Antibodies:

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Top referenced anti-JNK Antibodies

  1. Human Monoclonal JNK Primary Antibody for IP, WB - ABIN967329 : Adler, Fuchs, Kim, Kraft, King, Pelling, Ronai: jun-NH2-terminal kinase activation mediated by UV-induced DNA lesions in melanoma and fibroblast cells. in Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996 (PubMed)
    Show all 8 references for ABIN967329

  2. Human Polyclonal JNK Primary Antibody for IF, IHC (p) - ABIN391724 : Deng, Ren, Yang, Lin, Wu: A JNK-dependent pathway is required for TNFalpha-induced apoptosis. in Cell 2003 (PubMed)
    Show all 6 references for ABIN391724

  3. Human Polyclonal JNK Primary Antibody for EIA, WB - ABIN359636 : Luo, Ng, Jin, Ye, Han, Lin: Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation. in The Journal of biological chemistry 2003 (PubMed)
    Show all 5 references for ABIN359636

  4. Human Polyclonal JNK Primary Antibody for EIA - ABIN358374 : Ghosh: Inhibition of arachidonate 5-lipoxygenase triggers prostate cancer cell death through rapid activation of c-Jun N-terminal kinase. in Biochemical and biophysical research communications 2003 (PubMed)
    Show all 5 references for ABIN358374

  5. Human Polyclonal JNK Primary Antibody for EIA, IHC (p) - ABIN953314 : Dasgupta, Kar, Liu, Joseph, Kalyanaraman, Remington, Chen, Melendez: Reactive oxygen species control senescence-associated matrix metalloproteinase-1 through c-Jun-N-terminal kinase. in Journal of cellular physiology 2010 (PubMed)
    Show all 5 references for ABIN953314

  6. Human Monoclonal JNK Primary Antibody for FACS, WB - ABIN968866 : Fleming, Armstrong, Morrice, Paterson, Goedert, Cohen: Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7. in The Biochemical journal 2001 (PubMed)
    Show all 4 references for ABIN968866

  7. Human Polyclonal JNK Primary Antibody for IF, WB - ABIN401562 : Davis: Signal transduction by the c-Jun N-terminal kinase. in Biochemical Society symposium 1999 (PubMed)
    Show all 3 references for ABIN401562

  8. Human Polyclonal JNK Primary Antibody for IHC (p), WB - ABIN654887 : Han, Crowe: Jun amino-terminal kinase 1 activation promotes cell survival in ErbB2-positive breast cancer. in Anticancer research 2010 (PubMed)
    Show all 3 references for ABIN654887

  9. Human Polyclonal JNK Primary Antibody for IHC, IHC (p) - ABIN4327961 : Gao, Wang, Zhang, Yu, Ji, Wang, Zhang, Jiang, Jin, Huang, Zhang, Li: Tumor necrosis factor receptor-associated factor 5 (Traf5) acts as an essential negative regulator of hepatic steatosis. in Journal of hepatology 2016 (PubMed)
    Show all 2 references for ABIN4327961

  10. Human Monoclonal JNK Primary Antibody for WB - ABIN2452243 : Sung, Liang, Lee, Yen, Hsiao, Wang, Jiang-Shieh, Tsai, Chen: The protective effect of eupafolin against TNF-?-induced lung inflammation via the reduction of intercellular cell adhesion molecule-1 expression. in Journal of ethnopharmacology 2015 (PubMed)

More Antibodies against JNK Interaction Partners

Fruit Fly (Drosophila melanogaster) Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. n addition to significantly increasing the number of JNK target genes identified so far, our results reveal that the LE is a highly heterogeneous morphogenetic organizer, sculpted through crosstalk between JNK, segmental and AP signalling. This fine-tuning regulatory mechanism is essential to coordinate morphogenesis and dynamics of tissue sealing

  2. malignant transformation of the ras(V12)scrib(1 (show SCRIB Antibodies)) tumors requires bZIP protein Fos, the ETS (show ETS1 Antibodies)-domain factor Ets21c and the nuclear receptor Ftz-F1 (show NR5A2 Antibodies), all acting downstream of Jun-N-terminal kinase.

  3. Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction.

  4. ROS (show ROS1 Antibodies)/JNK/p38 (show MAPK14 Antibodies)/Upd (show UROD Antibodies) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.

  5. Significantly, the JNK pathway is responsible for the majority of the phenotypes and transcriptional changes downstream of Notch (show NOTCH1 Antibodies)-Src (show SRC Antibodies) synergy.

  6. This study demonstrated that the mechanism by which Bsk (show FRK Antibodies) is required for pruning is through reducing the membrane levels of the adhesion molecule (show NCAM1 Antibodies) Fasciclin II (show NCAM2 Antibodies) (FasII)

  7. Study solves the crystal structure of unphosphorylated DJNK in complex with adenylyl imidodiphosphate (AMP (show AMPH Antibodies)-PNP (show NP Antibodies)) and magnesium.

  8. PERK/ATF4 activated the JNK pathway through Rac1 and Slpr activation in apoptotic cells.

  9. Data show that oxidative stress and neuroinflammation are intrinsic components of TDP-43 (show TARDBP Antibodies)-associated neurodegeneration and the balance between cytoprotective JNK and cytotoxic p38 (show MAPK14 Antibodies) signaling dictates phenotypic outcome to TDP-43 (show TARDBP Antibodies) expression in Drosophila.

  10. Data show that the actin-Capping Protein (show TMOD4 Antibodies) (CP) alphabeta heterodimer, which regulates actin (show ACTB Antibodies) filament (F-actin (show ACTB Antibodies)) polymerization, limits Src (show SRC Antibodies)-induced apoptosis or tissue overgrowth by restricting JNK activation.

Human Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. The increase in c-Jun N-terminal kinase (c-Jun) and specificity protein 1 (SP1 (show SP1 Antibodies)) expressions was positively correlated with transforming growth factor beta 1 (TGFbeta1 (show TGFB1 Antibodies)) in both high glucose-treated renal mesangial cells (HRMCs) and diabetic kidneys.

  2. JNK1 physically and functionally interacted with VDR (show CYP27B1 Antibodies) and positively regulated VDR (show CYP27B1 Antibodies) expression at transcriptional and translational levels, which influenced calcitriol-mediated inhibition of cancer cell proliferation.

  3. In conclusion, our findings revealed DIP2 (show WDR3 Antibodies) as a novel effector downstream of Bsk (show FRK Antibodies) modulating the direction of axon projection.

  4. The release of infectious respiratory syncytial virus (RSV) virions from infected cells was significantly reduced by JNK1/2 siRNA knockdown, implicating JNK1/2 as a key host factor for RSV virus production.

  5. dMyc has an essential role in preventing JNK-mediated retinal glial activation

  6. the results identify the JNK/S6K1 (show RPS6KB1 Antibodies) axis as a key molecular mechanism whereby a high fat/sucrose diet impairs insulin (show INS Antibodies) action in retina.

  7. PXR (show NR1I2 Antibodies) regulates the intestinal epithelial barrier during inflammation by modulating cytokine-induced MLCK (show MYLK Antibodies) expression and JNK1/2 activation

  8. hese results indicate that DHA induces apoptosis of BGC-823 cells through JNK1/2 and p38 MAPK (show MAPK14 Antibodies) signaling pathways and DHA could serve as a potential additional chemotherapeutic agent for treatment of gastric cancer.

  9. MUC1 (show MUC1 Antibodies) promotes hepatocellular carcinoma progression and tumorigenesis and mediates autocrine TGF-b signaling by activating the JNK/AP-1 (show FOSB Antibodies) pathway in hepatocellular carcinoma cells, and makes MUC1 (show MUC1 Antibodies) and JNK as attractive targets for hepatocellular carcinoma therapy.

  10. Allograft tumor assays in mice demonstrate that this mechanism contributes to tumorigenesis driven by mutant IDH1 (show IDH1 Antibodies), a result confirmed by detection of JNK inactivation in human gliomas harboring IDH1 (show IDH1 Antibodies)-R132H mutations.

Mouse (Murine) Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. These data provide evidence for involvement of the TNF-alpha (show TNF Antibodies)-JNK axis in extracellular matrix remodeling.

  2. Phosphorylation levels of P38 (show CRK Antibodies) and JNK in siRNA-TMEM16A (show ANO1 Antibodies) group were lower than that of the Model group. Thus, TMEM16A (show ANO1 Antibodies) is one of the critical components of a signal transduction pathway that links renal injury to podocyte apoptosis in DN.

  3. Loss of Jnk1, but not Jnk2 (show MAPK9 Antibodies), in macrophages protects them from apoptosis, increasing cell survival, and this accelerates early atherosclerosis in LDL receptor (show LDLR Antibodies) knockout mice.

  4. Data indicate that in baicalein (BAI)-treated groups following AngII-infusion, p38-MAPK (show MAPK14 Antibodies) and JNK signaling were attenuated

  5. JNK1 physically and functionally interacted with VDR (show CYP27B1 Antibodies) and positively regulated VDR (show CYP27B1 Antibodies) expression at transcriptional and translational levels, which influenced calcitriol-mediated inhibition of cancer cell proliferation.

  6. data suggest that c-Jun-N-terminal kinase 1 may be recruited by nicotine and is functionally necessary for the acute effects of nicotine on learning and memory.

  7. the results identify the JNK/S6K1 (show RPS6KB1 Antibodies) axis as a key molecular mechanism whereby a high fat/sucrose diet impairs insulin (show INS Antibodies) action in retina.

  8. MOR (show OPRM1 Antibodies) epigenetic regulation requires multiple coordinated signals converging at the MOR (show OPRM1 Antibodies) promoter, involving mitogen-activated protein kinase (show MAPK1 Antibodies) (MAPK (show MAPK1 Antibodies)) activation and mitogen- and stress-activated protein kinase 1 (show RPS6KA5 Antibodies).

  9. activation of astrocyte MMP2 (show MMP2 Antibodies)/JNK1/2 contributes to the pathogenesis of pain hypersensitivity in the complex regional pain syndrome model

  10. JNK1/2-dependent regulation of p66ShcS36 phosphorylation, is reported.

Xenopus laevis Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3 (show CASP3 Antibodies)-dependent Proteolysis of JNK1-2 and Bid (show BID Antibodies).

  2. JNK signaling is required to establish microtubule stability and maintain tissue cohesion in the gut (show GUSB Antibodies).

  3. Data show that the death pathway is independent of ERK (show MAPK1 Antibodies) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (show CDK1 Antibodies) and JNK.

Arabidopsis thaliana Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. study reports MPK8 connects protein phosphorylation, Ca(2 (show CA2 Antibodies))+ and ROS (show ROS1 Antibodies) in wound-signaling pathway; suggests 2 major activation modes, Ca(2 (show CA2 Antibodies))+/CaMs and MAP kinase (show MAPK1 Antibodies) phosphorylation cascade, converge at MPK8 to monitor or maintain an essential part of ROS (show ROS1 Antibodies) homeostasis

Zebrafish Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein

  2. P38 (show MAPK14 Antibodies) and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.

  3. A dorsalization pathway that is exerted by Axin (show AXIN1 Antibodies)/JNK signaling and its inhibitor Aida (show AIDA Antibodies) during vertebrate embryogenesis, is defined.

  4. JNK-Mmp13 (show MMP13 Antibodies) signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo

Caenorhabditis elegans (C. elegans) Mitogen-Activated Protein Kinase 8 (MAPK8) interaction partners

  1. Our genetic study unravelled the underlying pathway where JNK-1 is acting independently of insulin (show INS Antibodies)-IGF-1 (show IGF1 Antibodies) signalling (IIS) pathway to modulate longevity. In support of in vivo results in silico docking study of UA with C. elegans JNK-1 ATP-binding site suggested promising binding affinity exhibiting binding energy of -8.11 kcalmol(-1). UA induced JNK-1 activation in wild-type animals underlie the importance of pharmacologi

  2. JNK-1 directly interacts with and phosphorylates DAF-16. Moreover, in response to heat stress, JNK-1 promotes the translocation of DAF-16 into the nucleus.

  3. The present study shows in Caenorhabditis elegans that ambient temperature (1-37 degrees C) specifically influences the activation (phosphorylation) of the MAP kinase JNK-1 as well as the nuclear translocation of DAF-16.

  4. the stress response is controlled by a c-Jun N-terminal kinase (JNK)-like mitogen-activated protein kinase (show MAPK1 Antibodies) (MAPK (show MAPK1 Antibodies)) signaling pathway, which is regulated by MLK-1 (show MAP3K9 Antibodies) MAPK (show MAPK1 Antibodies) kinase kinase (MAPKKK), MEK-1 (show MAP2K1 Antibodies) MAPK (show MAPK1 Antibodies) kinase (MAPKK), and KGB-1 (show KCNJ3 Antibodies) JNK-like MAPK (show MAPK1 Antibodies).

JNK (MAPK8) Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Alternative names and synonyms associated with JNK (MAPK8)

  • basket (bsk) antibody
  • mitogen-activated protein kinase 8 (MAPK8) antibody
  • mitogen-activated protein kinase 8 (Mapk8) antibody
  • mitogen-activated protein kinase 8 (mapk8) antibody
  • mitogen-activated protein kinase 8 (ATMPK8) antibody
  • mitogen-activated protein kinase 8b (mapk8b) antibody
  • Protein JNK-1 (jnk-1) antibody
  • AI849689 antibody
  • Bsk antibody
  • BSK/DJNK antibody
  • c-Jun antibody
  • CG5680 antibody
  • D-JNK antibody
  • D-junk antibody
  • DBSK/JNK antibody
  • dJNK antibody
  • DJNK/bsk antibody
  • Dmel\\CG5680 antibody
  • jnk antibody
  • JNK-46 antibody
  • JNK/SAPK antibody
  • jnk1 antibody
  • JNK1A2 antibody
  • JNK21B1/2 antibody
  • Junk antibody
  • mapk8 antibody
  • Prkm8 antibody
  • sapk1 antibody
  • SAPK1c antibody
  • SAPKa antibody
  • T10F20.15 antibody
  • zgc:112379 antibody

Protein level used designations for MAPK8

CG5680-PB , CG5680-PE , CG5680-PF , JNK , JUN kinase , Jun N-terminal kinase , Jun NH2-terminal kinase , Jun-N-terminal kinase , Jun-kinase , bsk-PB , bsk-PE , bsk-PF , c-Jun N-terminal kinase , c-Jun aminoterminal kinase , c-Jun-N-terminal kinase , drosophila JNK , JUN N-terminal kinase , MAP kinase 8 , c-Jun N-terminal kinase 1 , mitogen-activated protein kinase 8 isoform JNK1 alpha1 , mitogen-activated protein kinase 8 isoform JNK1 beta2 , stress-activated protein kinase 1 , stress-activated protein kinase 1c , JNK1 beta1 protein kinase , MAPK 8 , mitogen activated protein kinase 8 , protein kinase mitogen-activated 8 , stress-activated protein kinase JNK1 , SAPK gamma , c-jun NH2-terminal kinase , p54 gamma , jnk1a-1 , mitogen-activated protein kinase 8

GENE ID SPECIES
44801 Drosophila melanogaster
5599 Homo sapiens
26419 Mus musculus
116554 Rattus norvegicus
379876 Xenopus laevis
838394 Arabidopsis thaliana
65236 Danio rerio
177460 Caenorhabditis elegans
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