anti-Human JNK antibody for Biochemical Assay

Recommended JNK Antibody (supplied by: Log in to see )

Antigen
Mitogen-Activated Protein Kinase 8 (MAPK8) Antibodies
  • BSK
  • BSK/DJNK
  • Bsk
  • CG5680
  • D-JNK
  • D-junk
  • DBSK/JNK
  • DJNK
  • DJNK/bsk
  • Dmel\\CG5680
  • JNK
  • JNK/SAPK
  • Jnk
  • Junk
  • SAPKa
  • c-Jun
  • dJNK
  • jnk
  • JNK-46
  • JNK1
  • JNK1A2
  • JNK21B1/2
  • PRKM8
  • SAPK1
  • SAPK1c
  • AI849689
  • Prkm8
  • jnk1
  • sapk1
  • T10F20.15
  • mapk8
  • zgc:112379
  • basket
  • mitogen-activated protein kinase 8
  • mitogen-activated protein kinase 8b
  • Protein JNK-1
  • bsk
  • MAPK8
  • Mapk8
  • mapk8
  • ATMPK8
  • mapk8b
  • jnk-1
Epitope
pThr183, pTyr185
98
53
29
17
16
15
15
15
14
12
10
10
10
10
10
9
8
8
6
5
5
5
5
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
411
198
168
23
19
13
8
8
6
4
3
3
3
2
2
2
2
1
1
Host
Rabbit
310
116
3
2
Clonality
Polyclonal
Conjugate
This JNK antibody is un-conjugated
21
19
15
13
11
11
5
4
3
3
3
3
3
3
3
3
3
2
1
1
1
1
1
1
1
1
1
1
Application
Biochemical Assay (BCA)
327
209
98
76
62
59
39
37
31
20
19
8
4
3
3
2
2
1
1
1
1
1
1
1
1
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Catalog No. ABIN2666239
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2666238 BCA Rabbit pThr183, pTyr185 Log in to see Polyclonal

Top referenced anti-JNK antibody for Biochemical Assay

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General

Antigen Mitogen-Activated Protein Kinase 8 (MAPK8) Antibodies
Epitope pThr183, pTyr185
(98), (53), (29), (17), (16), (15), (15), (15), (14), (12), (10), (10), (10), (10), (10), (9), (8), (8), (6), (5), (5), (5), (5), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(411), (198), (168), (23), (19), (13), (8), (8), (6), (4), (3), (3), (3), (2), (2), (2), (2), (1), (1)
Host Rabbit
(310), (116), (3), (2)
Clonality (Clone)
Polyclonal   ( )
Conjugate This JNK antibody is un-conjugated
(21), (19), (15), (13), (11), (11), (5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Biochemical Assay (BCA)
(327), (209), (98), (76), (62), (59), (39), (37), (31), (20), (19), (8), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 4 references available
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Product Details anti-JNK Antibody

Target Details JNK Application Details Handling ProductDetails: References for anti-JNK antibody (ABIN2666239) Images
Purification The antibody was purified by affinity chromatography.
Clone Poly6513

Target Details JNK

Product Details anti-JNK Antibody Application Details Handling ProductDetails: References for anti-JNK antibody (ABIN2666239) Images back to top
Antigen
Alternative Name JNK (MAPK8 Antibody Abstract)
Background The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is activated by various cell stimuli and targets specific transcription factors, thus mediating immediate-early gene expression in response to cell stimuli. As with the other MAPKs, the core signaling unit is composed of a MAPKKK, typically MEKK1-MEKK4, or by one of the mixed lineage kinases (MLKs), which phosphorylate and activate MKK4/7. Upon activation, MKKs phosphorylate and activate the SAPK/JNK kinase. SAPK/JNK, when active as a dimer, can translocate to the nucleus and regulate transcription through its effects on c-Jun, ATF-2, and other transcription factors. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrome c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase plays a key role in T cell proliferation, apoptosis, and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Pathways MAPK Signaling, WNT Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor

Application Details

Product Details anti-JNK Antibody Target Details JNK Handling ProductDetails: References for anti-JNK antibody (ABIN2666239) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-JNK Antibody Target Details JNK Application Details ProductDetails: References for anti-JNK antibody (ABIN2666239) Images back to top
Format Liquid
Buffer phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Upon receipt, store undiluted at -20°C.

ProductDetails: References for anti-JNK antibody (ABIN2666239)

Product Details anti-JNK Antibody Target Details JNK Application Details Handling Images back to top
Background publications

Brandt, Abou-Eladab, Tiedge, Walzel: "Role of the JNK/c-Jun/AP-1 signaling pathway in galectin-1-induced T-cell death." in: Cell death & disease, Vol. 1, pp. e23, 2011

Whitmarsh, Davis: "Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals." in: Trends in biochemical sciences, Vol. 23, Issue 12, pp. 481-5, 1999

Chen, Meyer, Tan: "Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis." in: The Journal of biological chemistry, Vol. 271, Issue 2, pp. 631-4, 1996

Su, Jacinto, Hibi, Kallunki, Karin, Ben-Neriah: "JNK is involved in signal integration during costimulation of T lymphocytes." in: Cell, Vol. 77, Issue 5, pp. 727-36, 1994

Images

Product Details anti-JNK Antibody Target Details JNK Application Details Handling ProductDetails: References for anti-JNK antibody (ABIN2666239) back to top
Supplier Images
Western Blotting (WB) image for anti-JNK antibody (Mitogen-Activated Protein Kinase 8) (pThr183) (ABIN2666239) anti-Mitogen-Activated Protein Kinase 8 (MAPK8) (pThr183), (pTyr185) antibody