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anti-Dog (Canine) MAP2K2 antibody for Immunohistochemistry

Recommended MAP2K2 Antibody (supplied by: Log in to see )

Antigen
Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) Antibodies
  • AA589381
  • ATMKK2
  • CFC4
  • F27B13.50
  • F27B13_50
  • MAP KINASE KINASE 1
  • MAP kinase kinase 2
  • MAPKK2
  • MEK2
  • MK1
  • MK2
  • MKK2
  • PRKMK2
  • Prkmk2
Epitope
N-Term
33
22
15
15
14
14
12
10
10
8
8
5
5
4
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
230
106
89
7
4
3
2
1
Host
Rabbit
189
38
9
1
Clonality
Polyclonal
Conjugate
This MAP2K2 antibody is un-conjugated
10
10
9
7
7
7
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
187
80
78
39
27
26
23
15
13
11
7
4
2
1
1
Supplier
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Catalog No. ABIN2783572
$ 289.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0011363331 ABIN2783573 IHC WB Rabbit C-Term Log in to see Polyclonal 1
0.0011363331 ABIN2670889 IF IHC WB Mouse IgG2a Log in to see OTI1A2

Top referenced anti-MAP2K2 antibody for Immunohistochemistry

  • Chicken Polyclonal MAP2K2 Primary Antibody for IHC, WB - ABIN2783573 (1 Publications): Adjei, Cohen, Franklin, Morris, Wilson, Molina, Hanson, Gore, Chow, Leong, Maloney, Gordon, Simmons, Marlow, Litwiler, Brown, Poch, Kane, Haney, Eckhardt: Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. in Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008 (PubMed)

Similar anti-MAP2K2 Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Rattus) Dog (Canine) Cow (Bovine)
Western Blotting (WB) 187 Antibodies 82 Antibodies 69 Antibodies 8 Antibodies 2 Antibodies
Immunoprecipitation (IP) 27 Antibodies 13 Antibodies 13 Antibodies 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 28 Antibodies 18 Antibodies 12 Antibodies
Immunohistochemistry (IHC) 81 Antibodies 39 Antibodies 37 Antibodies 2 Antibodies

General

Antigen Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) Antibodies
Epitope N-Term
(33), (22), (15), (15), (14), (14), (12), (10), (10), (8), (8), (5), (5), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(230), (106), (89), (7), (4), (3), (2), (1)
Host Rabbit
(189), (38), (9), (1)
Clonality
Polyclonal
Conjugate This MAP2K2 antibody is un-conjugated
(10), (10), (9), (7), (7), (7), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Immunohistochemistry (IHC), Western Blotting (WB)
(187), (80), (78), (39), (27), (26), (23), (15), (13), (11), (7), (4), (2), (1), (1)
Pubmed 1 reference available
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Product Details anti-MAP2K2 Antibody

Target Details MAP2K2 Application Details Handling References for anti-MAP2K2 Antibody (ABIN2783572) Images
Blocking Peptide Blocking peptide for this product available: ABIN979766
Sequence LARRKPVLPA LTINPTIAEG PSPTSEGASE ANLVDLQKKL EELELDEQQK
Predicted Reactivity Mouse : 100 %, Rat : 100 %, Bovine : 90 %, Guinea pig : 90 %
Characteristics This is a rabbit polyclonal antibody against MAP2K2. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human MAP2K2

Target Details MAP2K2

Product Details anti-MAP2K2 Antibody Application Details Handling References for anti-MAP2K2 Antibody (ABIN2783572) Images back to top
Antigen
Alternative Name MAP2K2 (MAP2K2 Antibody Abstract)
Background MAP2K2 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in MAP2K2 gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
Molecular Weight 44 kDa
Gene ID 5605
NCBI Accession NP_109587, NM_030662
UniProt P36507
Pathways MAPK Signaling, RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-MAP2K2 Antibody Target Details MAP2K2 Handling References for anti-MAP2K2 Antibody (ABIN2783572) Images back to top
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 400 AA

Restrictions For Research Use only

Handling

Product Details anti-MAP2K2 Antibody Target Details MAP2K2 Application Details References for anti-MAP2K2 Antibody (ABIN2783572) Images back to top
Format Liquid
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage 4 °C,-20 °C
Storage Comment For short term use, store at 2-8 °C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-MAP2K2 Antibody (ABIN2783572)

Product Details anti-MAP2K2 Antibody Target Details MAP2K2 Application Details Handling Images back to top
Background publications

Adjei, Cohen, Franklin, Morris, Wilson, Molina, Hanson, Gore, Chow, Leong, Maloney, Gordon, Simmons, Marlow, Litwiler, Brown, Poch, Kane, Haney, Eckhardt: "Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 26, Issue 13, pp. 2139-46, 2008

Images

Product Details anti-MAP2K2 Antibody Target Details MAP2K2 Application Details Handling References for anti-MAP2K2 Antibody (ABIN2783572) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-MAP2K2 antibody (Mitogen-Activated Protein Kinase Kinase 2) (N-Term) (ABIN2783572) anti-Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) (N-Term) antibody
Immunohistochemistry (IHC) image for anti-MAP2K2 antibody (Mitogen-Activated Protein Kinase Kinase 2) (N-Term) (ABIN2783572) anti-Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) (N-Term) antibody (Image 2)
Western Blotting (WB) image for anti-MAP2K2 antibody (Mitogen-Activated Protein Kinase Kinase 2) (N-Term) (ABIN2783572) WB Suggested Anti-MAP2K2
Antibody Titration: 1 µg/mL
Positive Control: ...