Browse our MAP2K2 Proteins (MAP2K2)

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Mitogen-Activated Protein Kinase Kinase 2 Proteins (MAP2K2)
On are 21 Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) Proteins from 10 different suppliers available. Additionally we are shipping MAP2K2 Antibodies (278) and MAP2K2 Kits (10) and many more products for this protein. A total of 326 MAP2K2 products are currently listed.
AA589381, ATMKK2, CFC4, F27B13.50, F27B13_50, MAP KINASE KINASE 1, MAP kinase kinase 2, MAPKK2, MEK2, MK1, MK2, MKK2, PRKMK2
list all proteins Gene Name GeneID UniProt
MAP2K2 58960 P36506
MAP2K2 5605 P36507
MAP2K2 26396 Q63932

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MAP2K2 Proteins (MAP2K2) by Origin

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Top referenced MAP2K2 Proteins

  1. Human MAP2K2 Protein expressed in Escherichia coli (E. coli) - ABIN1098267 : Crews, Alessandrini, Erikson: The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. in Science (New York, N.Y.) 1992 (PubMed)
    Show all 2 references for 1098267

  2. Human MAP2K2 Protein expressed in Wheat germ - ABIN1310169 : Brady, Crowe, Turski, Hobbs, Yao, Chaikuad, Knapp, Xiao, Campbell, Thiele, Counter: Copper is required for oncogenic BRAF signalling and tumorigenesis. in Nature 2014 (PubMed)

More Proteins for MAP2K2 Interaction Partners

Human Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) interaction partners

  1. High MEK2 expression is associated with inflammation.

  2. there were significant decreases in intercellular adhesion molecules 1 (ICAM1 (show ICAM1 Proteins)), ezrin (EZR (show EZR Proteins)), mitogen-activated protein kinase kinase 2 (MAP2K2), and nitric oxide synthase 3 (NOS3 (show NANOS3 Proteins)) gene expressions in metabolic syndrome patients.

  3. The patient showed a paternally inherited 16p13.11 microduplication and a de novo 19p13.3 microdeletion involving the mitogen-activated protein kinase kinase 2 gene (MAP2K2), in which mutations cause the cardio-facio-cutaneous (CFC (show PTPN11 Proteins)) syndrome

  4. Data show that mitogen-activated protein kinase (show MAPK1 Proteins) kinases MEK1 (show MAP2K1 Proteins)/2 inhibitor pimasertib (MEKI) sensitized the cells to apoptosis through its ability to promote a G1 cell cycle arrest.

  5. the purpose of this paper was to investigate MAPK (show MAPK1 Proteins) downstream signalling molecules in Natural killer cell phenotypes from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients.

  6. at clinically relevant concentrations, cDDP binds to and inhibits MEK1 (show MAP2K1 Proteins)/2 and both the binding and inhibitory activity are related to its interaction with Cu bound to MEK1 (show MAP2K1 Proteins)/2

  7. Endocytosis separates EGF (show EGF Proteins) receptors from endogenous fluorescently labeled HRas (show HRAS Proteins) and diminishes receptor signaling to MAP kinases in endosomes.

  8. MEK1 (show MAP2K1 Proteins) levels are upregulated at transcriptional level whereas MEK2 levels are downregulated at posttranslational level.

  9. MEK1/2 inhibitor trametinib showed similar PFS and a response rate as docetaxel in patients with previously treated KRAS-mutant-positive non-small cell lung carcinoma.

  10. We report on a fourth familial case with transmission of CFC (show PTPN11 Proteins) syndrome from father to son due to a novel heterozygous sequence change c.376A>G (p.N126D) in exon 3 of MEK2 gene.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) interaction partners

  1. fluid shear stress induces autocrine TGF-beta (show TGFB1 Proteins)/ALK5 (show TGFBR1 Proteins)-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1 (show MAP2K1 Proteins)/2-mediated signaling.

  2. FGF2 (show FGF2 Proteins) is an extracellular inducer of COUP-TFII (show NR2F2 Proteins) expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII (show NR2F2 Proteins) expression prior to the onset of osteogenic differentiation

  3. REDD1 (show DDIT4 Proteins) is required for normal insulin (show INS Proteins)-stimulated signaling, and a subtle balance exists between MEK1 (show MAP2K1 Proteins)/2, REDD1 (show DDIT4 Proteins), and mTOR (show FRAP1 Proteins)

  4. MEK1 (show MAP2K1 Proteins) and MEK2 can substitute for each other but a minimum amount of MEK (show MDK Proteins) is critical for placenta development and embryo survival

  5. MK2 (show KCNA2 Proteins)/3 cascade plays a strategic role in controlling synaptic plasticity and cognition.

  6. MK2 (show KCNA2 Proteins) attenuates dendritic cell-mediated Th1 (show HAND1 Proteins) differentiation and autoimmune encephalomyelitis.

  7. analysis of p38 (show CRK Proteins)-MK2 (show KCNA2 Proteins)-activated Rsk (show RPS6KA1 Proteins) signaling in toll (show TLR4 Proteins)-like receptor-stimulated dendritic cells

  8. both MEK1 (show MAP2K1 Proteins) and MEK2 have crucial roles in the integration of mesenchymal and epithelial signals essential for the development of the entire respiratory tract

  9. MK2 (show KCNA2 Proteins) is responsible for resistance of p53 (show TP53 Proteins)-deficient tumors to cisplatin

  10. MK2 (show KCNA2 Proteins) plays a critical role in the development of apoptosis.

Arabidopsis thaliana Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) interaction partners

  1. the AtMKK2-AtMPK10 (show MAPK10 Proteins) MAPK (show MAPK1 Proteins) module regulates leaf venation complexity by altering polar auxin transport efficiency

  2. Treatment of Arabidopsis with a membrane rigidifier, DMSO, causes MPK4 (show MAPK4 Proteins) activation concomitantly with MEKK1 (show MAP3K1 Proteins) and MKK2 phosphorylation.

  3. Ca(2 (show CA2 Proteins)+) signaling occurred upstream of the MEKK1 (show MAP3K1 Proteins)-MKK2 pathway. MEKK1 (show MAP3K1 Proteins) was phosphorylated by calcium/calmodulin (show CALM Proteins)-regulated receptor-like kinase (CRLK1), which suggested that CRLK1 is one of candidates located upstream of MEKK1 (show MAP3K1 Proteins).

  4. Data indicate that MEKK2 (show MAP3K2 Proteins) is required for the mekk1 (show MAP3K1 Proteins), mkk1 (show MAP2K1 Proteins) mkk2, and mpk4 (show MAPK4 Proteins) autoimmune phenotypes.

  5. Data suggest that the MEKK1 (show MAP3K1 Proteins)-MKK1 (show MAP2K1 Proteins)/MKK2-MPK4 (show MAPK4 Proteins) kinase cascade negatively regulates MEKK2 (show MAP3K2 Proteins) and activation of MEKK2 (show MAP3K2 Proteins) triggers SUMM2-mediated immune responses.

  6. Data indicate that MKK2 plays a role in abiotic stress tolerance and plant disease resistance.

  7. double loss-of-function mutant (mkk1 (show MAP2K1 Proteins)/2) of MKK1 (show MAP2K1 Proteins) and MKK2 is shown to have marked phenotypes in development and disease

  8. Activation of MPK4 (show MAPK4 Proteins) by flg22 is impaired in the mkk1 (show MAP2K1 Proteins) mkk2 double mutants, suggesting that MKK1 (show MAP2K1 Proteins) and MKK2 function together with MPK4 (show MAPK4 Proteins) and MEKK1 (show MAP3K1 Proteins) in a MAP kinase (show MAPK1 Proteins) cascade to negatively regulate innate immune responses in plants.

MAP2K2 Protein Profile

Protein Summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Alternative names and synonyms associated with MAP2K2

  • mitogen activated protein kinase kinase 2 (Map2k2)
  • mitogen-activated protein kinase kinase 2 (MAP2K2)
  • mitogen-activated protein kinase kinase 2 (Map2k2)
  • mitogen-activated protein kinase kinase 2 (MKK2)
  • AA589381 protein
  • ATMKK2 protein
  • CFC4 protein
  • F27B13.50 protein
  • F27B13_50 protein
  • MAP KINASE KINASE 1 protein
  • MAP kinase kinase 2 protein
  • MAPKK2 protein
  • MEK2 protein
  • MK1 protein
  • MK2 protein
  • MKK2 protein
  • PRKMK2 protein

Protein level used designations for MAP2K2

ERK activator kinase 2 , MAP kinase kinase 2 , MAPK/ERK kinase 2 , MAPKK 2 , MEK 2 , MEK2 , dual specificity mitogen-activated protein kinase kinase 2 , mitogen-activated protein kinase kinase 2, p45 , MAP kinase/Erk kinase , mitogen activated protein kinase kinase 2 , protein kinase, mitogen activated, kinase 2, p45 , dual specificity mitogen activated protein kinase kinase 2 , mitogen-activated protein kinase kinase type 2

58960 Rattus norvegicus
5605 Homo sapiens
26396 Mus musculus
611939 Canis lupus familiaris
396349 Gallus gallus
510434 Bos taurus
829103 Arabidopsis thaliana
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