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Browse our MAP2K3 Proteins (MAP2K3)

Full name:
Mitogen-Activated Protein Kinase Kinase 3 Proteins (MAP2K3)
On www.antibodies-online.com are 14 Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3) Proteins from 8 different suppliers available. Additionally we are shipping MAP2K3 Antibodies (277) and MAP2K3 Kits (9) and many more products for this protein. A total of 318 MAP2K3 products are currently listed.
Synonyms:
AW212142, map2k3, MAPKK3, MEK3, MKK3, mMKK3b, Prkmk3, SAPKK-2, SAPKK2, zMKK3
list all proteins Gene Name GeneID UniProt
Rat MAP2K3 MAP2K3 303200  
MAP2K3 5606 P46734
MAP2K3 26397 O09110

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MAP2K3 Proteins (MAP2K3) by Origin

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Top referenced MAP2K3 Proteins

  1. Human MAP2K3 Protein expressed in Escherichia coli (E. coli) - ABIN667410 : Barr, Marjoram, Xu, Snyderman: Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3. in Biochemical and biophysical research communications 2002 (PubMed)
    Show all 2 references for ABIN667410

More Proteins for MAP2K3 Interaction Partners

Human Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3) interaction partners

  1. MKK3 overexpression upregulated the cyclin-dependent kinase (show CDK1 Proteins) inhibitors, p16 INK4A and p15 INK4B (show CDKN2B Proteins) in hepatocellular carcinoma cells was Bim1, was downregulated following MKK3 overexpression.

  2. Our results suggest that asthma is associated with MKK3 over-expression in CD8 (show CD8A Proteins)+ cells; we have also demonstrated that MKK3 may be critical for airway neutrophilia

  3. MicroRNA-21 promotes hepatocellular carcinoma HepG2 cell proliferation through repression of mitogen-activated protein kinase-kinase 3.

  4. study detected higher MKK3 activation in isolated peripheral blood mononuclear cells from septic patients compared with nonseptic controls

  5. study concludes MAP2K3 is a reproducible obesity locus that may affect body weight via complex mechanisms involving appetite regulation and hypothalamic inflammation

  6. miR-20a acts in a feedback loop to repress the expression of MKK3 and to negatively regulate the p38 pathway-mediated VEGF-induced endothelial cell migration and angiogenesis

  7. Data suggest aberrant MAP2K protein (MKK3, MKK4 (show MAP2K4 Proteins), MKK6 (show MAP2K6 Proteins), and MKK7 (show MAP2K7 Proteins)) expression indicates that altered cellular signal transduction mediated via JNK (show MAPK8 Proteins) and p38 (show CRK Proteins) may be common in bladder cancer.

  8. the balance between MKK6 (show MAP2K6 Proteins) and MKK3 mediates p38 MAPK (show MAPK14 Proteins) associated resistance to cisplatin in NSCLC

  9. LFA-1 (show ITGAL Proteins)-induced stabilization of ARE-containing mRNAs in T cells is dependent on HuR (show ELAVL1 Proteins), and occurs through the Vav-1 (show VAV1 Proteins), Rac1/2, MKK3 and p38MAPK (show MAPK14 Proteins) signaling cascade

  10. The p38 MAPK (show MAPK14 Proteins) pathway transgene is dispensable for the development of natural killer (NK)T cells; however, NKT (show SLC22A6 Proteins) cell cytokine production and NKT (show SLC22A6 Proteins)-mediated liver damage are highly dependent on activation of this pathway.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3) interaction partners

  1. miR (show MLXIP Proteins)-21a-5p inhibited BPA (show DST Proteins) induced adipocyte differentiation by targeting map2k3 through MKK3/p38/MAPK (show MAPK14 Proteins) in 3T3-L1 cells

  2. this study demonstrates that MKK3 influences mitochondrial quality by affecting the expression of mitochondrial proteins, including TCA cycle enzymes, and mitophagy, which consequently regulates the inflammatory response.

  3. Exendin-4 treatment improves cardiac function, attenuates cardiac remodeling, and promotes angiogenesis in the infarcted myocardium through MKK3 and Akt-1 (show AKT1 Proteins) pathway.

  4. Our results suggest that asthma is associated with MKK3 over-expression in CD8 (show CD8A Proteins)+ cells; we have also demonstrated that MKK3 may be critical for airway neutrophilia

  5. MKK3 and MKK6 (show MAP2K6 Proteins) differentially regulate bone loss due to estrogen withdrawal. MKK3 directly mediates osteoclastogenesis while MKK6 (show MAP2K6 Proteins) likely contributes to pro-inflammatory cytokine production that promotes osteoclast formation.

  6. results designate MKK3 as a novel, positive regulator of SCF (show KITLG Proteins)-induced mast cell proliferation and a critical signaling protein for AP-1 (show JUN Proteins)-dependent IL-6 (show IL6 Proteins) production

  7. findings demonstrate a critical role for mitochondria in the pathogenesis of sepsis that involves a previously unrecognized function of MKK3 in mitochondrial quality control

  8. Endothelial MKK3 is neede for inflammatory cell recruitment to the lungs, mitochondrial oxidant-mediated AP-1 (show JUN Proteins), NF-kappaB (show NFKB1 Proteins) activation, & ICAM-1 (show ICAM1 Proteins) expression during LPS (show TLR4 Proteins) challenge.

  9. mast cell MKK3 signaling contributes to IgE-dependent allergic inflammation and is a specific regulator of FcepsilonRI (show FCER1A Proteins)-induced IL-4 (show IL4 Proteins) production.

  10. LFA-1 (show ITGAL Proteins)-induced stabilization of ARE-containing mRNAs in T cells is dependent on HuR (show ELAVL1 Proteins), and occurs through the Vav-1 (show VAV1 Proteins), Rac1/2, MKK3 and p38MAPK (show MAPK14 Proteins) signaling cascade

MAP2K3 Protein Profile

Protein Summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.

Alternative names and synonyms associated with MAP2K3

  • MAP kinase activator XMEK3 (map2k3)
  • mitogen activated protein kinase kinase 3 (Map2k3)
  • mitogen-activated protein kinase kinase 3 (MAP2K3)
  • mitogen-activated protein kinase kinase 3 (Map2k3)
  • mitogen-activated protein kinase kinase 6 (map2k6)
  • AW212142 protein
  • map2k3 protein
  • MAPKK3 protein
  • MEK3 protein
  • MKK3 protein
  • mMKK3b protein
  • Prkmk3 protein
  • SAPKK-2 protein
  • SAPKK2 protein
  • zMKK3 protein

Protein level used designations for MAP2K3

MAP kinase kinase 3 , MAPK/ERK kinase 3 , MAPKK 3 , MEK 3 , SAPK kinase 2 , dual specificity mitogen-activated protein kinase kinase 3 , stress-activated protein kinase kinase 2 , mitogen activated protein kinase kinase 3 , protein kinase, mitogen-activated, kinase 3 , MAP kinase kinase 6 , MAPKK 6 , dual specificity mitogen-activated protein kinase kinase 6 , mitogen-activated protein kinase kinase 3

GENE ID SPECIES
399150 Xenopus laevis
303200 Rattus norvegicus
5606 Homo sapiens
489547 Canis lupus familiaris
26397 Mus musculus
516039 Bos taurus
416496 Gallus gallus
65239 Danio rerio
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