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|Application / Reactivity||Human|
|Dot Blot (DB)||14 Antibodies|
|Enzyme Immunoassay (EIA)||4 Antibodies|
|Flow Cytometry (FACS)||8 Antibodies|
|Immunochromatography (IC)||3 Antibodies|
|Immunocytochemistry (ICC)||6 Antibodies|
|Immunofluorescence (IF)||58 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||13 Antibodies|
|Immunohistochemistry (IHC)||141 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||2 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||34 Antibodies|
|Immunoprecipitation (IP)||17 Antibodies|
|Western Blotting (WB)||191 Antibodies|
|Antigen||Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) Antibodies|
|Conjugate||This MAP2K4 antibody is un-conjugated Alternatives|
Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
|2 references available|
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Product Details anti-MAP2K4 AntibodyTarget Details MAP2K4 Application Details Handling References for anti-MAP2K4 Antibody (ABIN969268) Images
|Immunogen||Purified recombinant fragment of human MAP2K4 expressed in E. coli.|
Target Details MAP2K4Product Details anti-MAP2K4 Antibody Application Details Handling References for anti-MAP2K4 Antibody (ABIN969268) Images back to top
|Alternative Name||MAP2K4 (MAP2K4 Antibody Abstract)|
|Background||This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.Tissue specificity: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues .|
|Molecular Weight||42 kDa|
|Pathways||MAPK Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway|
Application DetailsProduct Details anti-MAP2K4 Antibody Target Details MAP2K4 Handling References for anti-MAP2K4 Antibody (ABIN969268) Images back to top
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MAP2K4 Antibody Target Details MAP2K4 Application Details References for anti-MAP2K4 Antibody (ABIN969268) Images back to top
|Buffer||Ascitic fluid containing 0.03 % sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store at 4 °C or at -20 °C for long term.|
References for anti-MAP2K4 Antibody (ABIN969268)Product Details anti-MAP2K4 Antibody Target Details MAP2K4 Application Details Handling Images back to top
|Product cited in:||
Song, Coffa, Fu et al.: "How does arrestin assemble MAPKs into a signaling complex?" in: The Journal of biological chemistry, Vol. 284, Issue 1, pp. 685-95, 2008 (PubMed).
Yoshizawa, Hammaker, Sweeney et al.: "Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 5, pp. 3252-8, 2008 (PubMed).
ImagesProduct Details anti-MAP2K4 Antibody Target Details MAP2K4 Application Details Handling References for anti-MAP2K4 Antibody (ABIN969268) back to top