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anti-Rat (Rattus) MAP2K4 antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended MAP2K4 Antibody (supplied by: Log in to see )

Antigen
Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) Antibodies
  • 2
  • 142758_at
  • ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4
  • ATMEK4
  • ATMKK4
  • CG9738
  • CT27508
  • CT38386
  • D-MKK4
  • DmelCG12798
  • Dmel\\CG9738
  • dMkk4
  • DMKK4
  • dMKK4
  • F19C24.26
  • F19C24_26
  • hep
  • jnkk
  • JNKK
  • JNKK1
  • jnkk1
  • Jnkk2
  • JNKK2
  • map2k4
  • MAP KINASE KINASE 4
  • MAPKK4
  • mapkk4
  • Mapkk7
  • MEK4
  • mek4
  • Mek7
  • mitogen-activated protein kinase kinase 4
  • MKK4
  • mkk4
  • MKK4A-l
  • Mkk7
  • Mpk4
  • PRKMK4
  • prkmk4
  • SAPKK-1
  • SAPKK1
  • Sek1
  • sek1
  • SEK1
  • SEK1/MKK4
  • serk1
  • SERK1
  • Serk1
  • SKK1
  • xmek2
  • zgc:136500
Epitope
AA 240-280, pThr261
54
41
28
24
22
19
15
12
11
5
5
4
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
292
136
106
9
8
4
4
2
Host
Rabbit
271
34
Clonality
Polyclonal
Conjugate
This MAP2K4 antibody is un-conjugated
12
12
11
8
8
8
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
197
140
112
58
32
17
14
12
8
6
4
3
1
Supplier
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Catalog No. ABIN702745
$ 291.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008812695 ABIN877874 IF (p) Alexa Fluor 350 Rabbit IgG AA 240-280, pThr261 Log in to see Polyclonal
0.0008812695 ABIN877875 IF (p) Alexa Fluor 555 Rabbit IgG AA 240-280, pThr261 Log in to see Polyclonal
0.0008812695 ABIN877878 IF (p) Alexa Fluor 488 Rabbit IgG AA 240-280, pThr261 Log in to see Polyclonal
0.0008812695 ABIN877877 IF (p) Alexa Fluor 647 Rabbit IgG AA 240-280, pThr261 Log in to see Polyclonal
0.0008812695 ABIN702750 IF (p) Cy5.5 Rabbit IgG AA 240-280, pThr261 Log in to see Polyclonal
0.0008812695 ABIN702749 IF (p) Cy5 Rabbit IgG AA 240-280, pThr261 Log in to see Polyclonal
0.0008812695 ABIN702748 IF (p) Cy3 Rabbit IgG AA 240-280, pThr261 Log in to see Polyclonal
0.0008812695 ABIN702752 IF (p) FITC Rabbit IgG AA 240-280, pThr261 Log in to see Polyclonal
0.0008812695 ABIN702751 IF (p) Cy7 Rabbit IgG AA 240-280, pThr261 Log in to see Polyclonal
0.0008812695 ABIN2804129 IF (p) Alexa Fluor 594 Rabbit IgG AA 240-280, pThr261 Log in to see Polyclonal
0.0008812695 ABIN745643 IF (p) IHC (p) WB Rabbit IgG pSer257 Log in to see Polyclonal
0.0008812695 ABIN745673 IF (p) IHC (p) WB Rabbit IgG pSer257, pThr261 Log in to see Polyclonal

Similar anti-MAP2K4 Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine)
ELISA 22 Antibodies 27 Antibodies
Immunochromatography (IC) 3 Antibodies 3 Antibodies
Immunocytochemistry (ICC) 3 Antibodies 3 Antibodies
Immunofluorescence (IF) 32 Antibodies 32 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 13 Antibodies 13 Antibodies
Immunohistochemistry (IHC) 56 Antibodies 63 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 17 Antibodies 20 Antibodies
Immunoprecipitation (IP) 1 Antibodies
Western Blotting (WB) 62 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies

General

Antigen Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) Antibodies
Epitope AA 240-280, pThr261
(54), (41), (28), (24), (22), (19), (15), (12), (11), (5), (5), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(292), (136), (106), (9), (8), (4), (4), (2)
Host Rabbit
(271), (34)
Clonality
Polyclonal
Conjugate This MAP2K4 antibody is un-conjugated
(12), (12), (11), (8), (8), (8), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(197), (140), (112), (58), (32), (17), (14), (12), (8), (6), (4), (3), (1)
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Product Details anti-MAP2K4 Antibody

Target Details MAP2K4 Application Details Handling Images
Specificity This antibody will cross react with MAP2K3 when phosphorylated at Thr222, MAP2K6 when phosphorylated at Thr211, and MAP2K7 when phosphorylated at Thr275.
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human MEK4 around the phosphorylation site of Thr261
Isotype IgG

Target Details MAP2K4

Product Details anti-MAP2K4 Antibody Application Details Handling Images back to top
Antigen
Alternative Name Mek4 (MAP2K4 Antibody Abstract)
Background

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.

Subcellular location: Cytoplasm, Nucleus


Synonyms: Dual specificity mitogen-activated protein kinase kinase 4, MAP kinase kinase 4, MAPKK 4, JNK-activating kinase 1, MAPK/ERK kinase 4, MEK 4, SAPK/ERK kinase 1, SEK1, Stress-activated protein kinase kinase 1, SAPK kinase 1, SAPKK-1, SAPKK1, c-Jun N-terminal kinase kinase 1, JNKK, MAP2K4, JNKK1, MEK4, MKK4, PRKMK4, SERK1, SKK1
Gene ID 6416
UniProt P45985
Research Area Signaling
Pathways MAPK Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway

Application Details

Product Details anti-MAP2K4 Antibody Target Details MAP2K4 Handling Images back to top
Application Notes WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Restrictions For Research Use only

Handling

Product Details anti-MAP2K4 Antibody Target Details MAP2K4 Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-MAP2K4 Antibody Target Details MAP2K4 Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-MAP2K4 antibody (Mitogen-Activated Protein Kinase Kinase 4) (AA 240-280) (ABIN702745) Formalin-fixed and paraffin embedded rat lung labeled with Anti Phospho-SEK1/MKK4 (Th...
Immunohistochemistry (IHC) image for anti-MAP2K4 antibody (Mitogen-Activated Protein Kinase Kinase 4) (AA 240-280) (ABIN702745) Formalin-fixed and paraffin embedded rat skeletal muscle labeled with Anti Phospho-SE...