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Human MAP2K5 Protein expressed in Wheat germ - ABIN1310183
García-Hoz, Sánchez-Fernández, Díaz-Meco, Moscat, Mayor, Ribas: G alpha(q) acts as an adaptor protein in protein kinase C zeta (PKCzeta)-mediated ERK5 activation by G protein-coupled receptors (GPCR). in The Journal of biological chemistry 2010
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Insights into a molecular mechanism by which MEK5 transcriptionally upregulated by Stat3 (show STAT3 Proteins) augments breast cancer cell EMT (show ITK Proteins), which subsequently enhances cancer cell invasion and metastasis. This finding may suggest that Stat3 (show STAT3 Proteins) and MEK5/Erk5 (show MAPK7 Proteins) pathways could be an effective therapeutic target for inhibition of breast cancer invasion and metastasis.
Our findings confirm an association between the BTBD9, MEIS1, and MAP2K5/SKOR1 SNPs and periodic limb movements of sleep in an elderly cohort.
Specifically, CKS1B (show CKS1B Proteins) and MAP2K5 significantly inhibited hepatitis C viral RNA replication. PACSIN1 (show PACSIN1 Proteins), by contrast, inhibited hepatitis C virus infection by decreasing the level of viral protein p7.
High MEK5 expression is associated with colorectal cancer.
SEC16B, MC4R, MAP2K5 and KCTD15 (rs17782313, rs543874, rs2241423 and rs11084753) polymorphisms are associated with the risk for children obesity in China.
Periodic leg movements during sleep are associated with polymorphisms in BTBD9 (show BTBD9 Proteins), TOX3 (show TOX3 Proteins)/BC034767, MEIS1 (show MEIS1 Proteins), MAP2K5/SKOR1, and PTPRD (show PTPRD Proteins)
Inhibitors of apoptosis proteins regulate myogenic differentiation by directly suppressing MEKK2 (show MAP3K2 Proteins)/3-MEK5-ERK5 (show MAPK7 Proteins) signaling.
MiR (show MLXIP Proteins)-330-3p and MAP2K5 are potentially important contributors to mood and anxiety-related traits
MEK5/ERK5 (show MAPK7 Proteins) signaling suppresses estrogen receptor (show ESR1 Proteins) expression and promotes hormone-independent tumorigenesis.
Single nucleotide polymorphism in the MAP2K5 gene is associated with BMI and obesity.
MEK5 overexpression inhibits differentiation of osteoblasts.
the MEK5-ERK5 (show MAPK7 Proteins) MAP kinase (show MAPK1 Proteins) signaling pathway has a critical role in BAFF (show TNFSF13B Proteins)-induced mature B cell survival and homeostatic maintenance of B2 cell numbers
The MEK5/ERK5 (show MAPK7 Proteins) pathway also mediates FSS-induced Runx-2 (show RUNX2 Proteins) expression in osteoblast differentiation.
finding suggested that REST promoted primordial germ cells survival via regulation of the Mek5 expression
PB1 (show GPR97 Proteins) domain mediates the association of MEKK2 (show MAP3K2 Proteins) and MEKK3 (show MAP3K3 Proteins) with MEK5 and that the respective PB1 (show GPR97 Proteins) domains of these kinases are critical for regulation of the ERK5 (show MAPK7 Proteins) pathway.
MEK5 is an activator of ERK5 (show MAPK7 Proteins) and an essential regulator of cell survival that is required for normal embryonic development
the N terminus of MEK5alpha is critical for the specific organization of the components of the ERK5 (show MAPK7 Proteins) signaling pathway
MEK5 and big MAP kinase 1 (BMK1 (show MAPK7 Proteins)) function downstream of MEKK3 (show MAP3K3 Proteins) in a signaling cascade that induces calcineurin (show PPP3CA Proteins) activity through phosphorylation of MCIP1 (show PPP3R1 Proteins)
A noncanonical function of Map2k5 domain is decribed for coordinated erk5 (show MAPK7 Proteins) kinase and map2k7 (show MAP2K7 Proteins) signaling.
Results show the critical involvement of the MEK5-ERK5 (show MAPK7 Proteins) pathway in thymocyte development distinct from that of ERK1/2 and highlight the importance of the MAPK (show MAPK1 Proteins) network in mediating differential effects pertaining to T-cell differentiation and apoptosis.
MKK4 (show MAP2K4 Proteins), MKK5, MKK7 (show MAP2K7 Proteins), and MKK9, are responsible for the activation of MPK3 (show MAPK3 Proteins) and MPK6 (show MAPK6 Proteins) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (show MAPK1 Proteins) signaling through MKK4 (show MAP2K4 Proteins)/5/7/9-MPK3 (show MAPK3 Proteins)/6 cascades.
Overexpression of MKK5 in wild-type plants enhanced their tolerance to salt treatments. Another kinase, MPK6 (show MAPK6 Proteins), was also involved in the MKK5-mediated iron superoxide dismutase (FSD) signalling pathway in salt stress.
our data indicate that EDR1 physically associates with MKK4 (show MAP2K4 Proteins)/MKK5 and negatively regulates the MAPK (show MAPK1 Proteins) cascade to fine-tune plant innate immunity.
Data indicate that in the MKK5-RNAi (RNA interference) lines, the induction of CSD1 and CSD2 (show TGFB1 Proteins) as well as the activation of MKK5 activity were completely arrested.
Results suggest that the YDA-MKK4 (show MAP2K4 Proteins)/MKK5-MPK3 (show MAPK3 Proteins)/MPK6 (show MAPK6 Proteins) cascade functions downstream of the ER receptor in regulating localized cell proliferation, which further shapes the morphology of plant organs.
MKK5 functions both in ozone-induced activation of MPK3 (show MAPK3 Proteins) and MPK6 (show MAPK6 Proteins) and in integrating reactive oxygen species homeostasis during ozone stress.
MKK5 is a key regulator of stomatal development and patterning.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
MAP kinase kinase 5
, MAPK/ERK kinase 5
, MAPKK 5
, MEK 5
, dual specificity mitogen-activated protein kinase kinase 5
, mitogen-activated protein kinase kinase 5
, MAP kinase kinase MEK5b
, MAPK/ERK kinese 5
, mitogen activated protein kinase kinase 5