Browse our MAP2K6 Proteins (MAP2K6)

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Mitogen-Activated Protein Kinase Kinase 6 Proteins (MAP2K6)
On are 18 Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) Proteins from 8 different suppliers available. Additionally we are shipping MAP2K6 Antibodies (215) and MAP2K6 Kits (22) and many more products for this protein. A total of 270 MAP2K6 products are currently listed.
list all proteins Gene Name GeneID UniProt
MAP2K6 5608 P52564
Rat MAP2K6 MAP2K6 114495  
MAP2K6 26399 P70236

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MAP2K6 Proteins (MAP2K6) by Origin

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Top referenced MAP2K6 Proteins

  1. Human MAP2K6 Protein expressed in Baculovirus infected Insect Cells - ABIN2002815 : Choudhary, Kumar, Gnad, Nielsen, Rehman, Walther, Olsen, Mann: Lysine acetylation targets protein complexes and co-regulates major cellular functions. in Science (New York, N.Y.) 2009 (PubMed)
    Show all 5 references for 2002815

  2. Human MAP2K6 Protein expressed in Baculovirus infected Insect Cells - ABIN2002813 : Stein, Brady, Yang, Young, Barbosa: Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade. in The Journal of biological chemistry 1996 (PubMed)
    Show all 5 references for 2002813

More Proteins for MAP2K6 Interaction Partners

Human Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) interaction partners

  1. Data indicate that mitogen-activated protein kinase kinase 6 (MKK6) levels were substantially higher in monocytes than in neutrophils.

  2. Data show significant increase in the expression of MKK6 in Esophageal, Stomach, and Colon cancers as compared to controls.

  3. uncover a new mechanism of deactivation of MKK6-p38 (show CRK Proteins) and substantiate a novel regulatory role of FBXO31 (show FBXO5 Proteins) in stress response

  4. Serine phosphorylation of p66shc (show SHC1 Proteins) is carried out by active MKK6. beta-Amyloid-induced ROS (show ROS1 Proteins) production and apoptosis increased in the presence of MKK6 and p66shc (show SHC1 Proteins), which directly associate.

  5. The models confirmed the reaction order, revealed processivity in the phosphorylation of MEK6 by ASK1 (show MAP3K5 Proteins), and suggested that the order of phosphorylation is dictated by both binding and catalysis rates.

  6. crystal structure of human non-phosphorylated MAP2K6 (npMAP2K6) complexed with an ATP analogue was determined at 2.6 A resolution and represents an auto-inhibition state of MAP2K6

  7. Data suggest aberrant MAP2K protein (MKK3 (show MAP2K3 Proteins), MKK4 (show MAP2K4 Proteins), MKK6, and MKK7 (show MAP2K7 Proteins)) expression indicates that altered cellular signal transduction mediated via JNK (show MAPK8 Proteins) and p38 (show CRK Proteins) may be common in bladder cancer.

  8. the balance between MKK6 and MKK3 (show MAP2K3 Proteins) mediates p38 MAPK (show MAPK14 Proteins) associated resistance to cisplatin in NSCLC

  9. activation by mechanical stretch induces HMGB1 (show HMGB1 Proteins) and cytokine expression in A549 cells

  10. Results suggest that the p38alpha (show MAPK14 Proteins), MAPK (show MAPK1 Proteins), and MKK6 play prominent roles in IL-1beta (show IL1B Proteins) and C/EBP-beta (show CEBPB Proteins)-mediated C3 gene expression in astrocytes.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) interaction partners

  1. MKK3 (show MAP2K3 Proteins) and MKK6 differentially regulate bone loss due to estrogen withdrawal. MKK3 (show MAP2K3 Proteins) directly mediates osteoclastogenesis while MKK6 likely contributes to pro-inflammatory cytokine production that promotes osteoclast formation.

  2. Activation of distinct p38MAPK (show MAPK14 Proteins) isoforms is regulated by the selective and synchronized action of two kinases, MKK3 (show MAP2K3 Proteins) and MKK6, in response to cell stress.

  3. MKK6 is downreglated in peripheral CD4 (show CD4 Proteins)(+)T cells

  4. p38alpha (show MAPK14 Proteins) can negatively regulate the stability of the MKK6 mRNA and thus control the steady-state concentration of one of its upstream activators

  5. Involvement of MKK6 in apoptotic cell death in thymocytes.

  6. MKK6 is one of three different protein kinases which activate p38 MAPK (show MAPK14 Proteins) in vitro.

  7. MKK3 (show MAP2K3 Proteins) and MKK6 are rapidly activated during engagement of the Type I IFN receptor and play important roles in Type I IFN signaling and the generation of IFN responses

  8. increased activity of Sox9 (show SOX9 Proteins) accounts at least in part for the phenotype caused by constitutive activation of MKK6 in chondrocytes

  9. These results indicate that TAK1 (show NR2C2 Proteins) and MKK6 constitute the p38 (show CRK Proteins) signalling pathway to participate to Oc differentiation by RANKL (show TNFSF11 Proteins) through p65 (show NFkBP65 Proteins) phosphorylation and NFATc1 (show NFATC1 Proteins) induction.

  10. All these results suggest that DGK (show DGUOK Proteins) may play a role in glucose transport in the skeletal muscle cells through modulating a MKK3 (show MAP2K3 Proteins)/6-p38 (show CRK Proteins) signaling pathway.

Arabidopsis thaliana Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) interaction partners

  1. Arabidopsis MPK4 (show MAPK4 Proteins) can interact with and be phosphorylated by the cytokinesis-related MAP kinase (show MAPK1 Proteins) kinase, AtMKK6.

  2. AtMKK6-AtMPK13 module positively regulates lateral root formation.

  3. Plants with mutations in the MKK6/ANQ gene exhibit severe defects in cytokinesis.

MAP2K6 Protein Profile

Protein Summary

This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.

Alternative names and synonyms associated with MAP2K6

  • mitogen-activated protein kinase kinase 6 (MAP2K6)
  • mitogen-activated protein kinase kinase 6 (Map2k6)
  • mitogen-activated protein kinase kinase 6 (MKK6)
  • mitogen-activated protein kinase kinase 6 (map2k6)
  • ANQ1 protein
  • ARABIDOPSIS NQK1 protein
  • ATMKK6 protein
  • map2k3 protein
  • MAP kinase kinase 6 protein
  • MAPKK6 protein
  • MEK6 protein
  • MIK19.2 protein
  • MIK19_2 protein
  • MKK3 protein
  • Mkk6 protein
  • Prkmk6 protein
  • SAPKK-3 protein
  • SAPKK3 protein
  • zMKK3 protein

Protein level used designations for MAP2K6

MAPK/ERK kinase 6 , MAPKK 6 , MEK 6 , SAPK kinase 3 , dual specificity mitogen-activated protein kinase kinase 6 , protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6) , stress-activated protein kinase kinase 3 , MAP kinase kinase 6 , mitogen activated protein kinase kinase 6 , protein kinase, mitogen activated, kinase 6 , mitogen-activated protein kinase kinase 3

5608 Homo sapiens
114495 Rattus norvegicus
26399 Mus musculus
286883 Bos taurus
417445 Gallus gallus
100355230 Oryctolagus cuniculus
100731419 Cavia porcellus
835759 Arabidopsis thaliana
65239 Danio rerio
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