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let-7g induces porcine granulosa cells apoptosis by inhibiting the MAP3K1 gene, which promotes FoxO1 (show FOXO1 ELISA Kits) expression and dephosphorylation with nuclear accumulation.
goya and kinase-deficient Map3k1 homozygotes initially develop supernumerary cochlear outer hair cells (OHCs) that subsequently degenerate.
These data highlight the crucial role of MAP3K1 in the development and function of the mouse inner ear and hearing.
Dioxin exposure markedly inhibited c-Jun (show JUN ELISA Kits) phosphorylation in Map3k1-deficient embryonic eyelid epithelium, suggesting that dioxin-induced AHR (show AHR ELISA Kits) pathways can synergize with gene mutations to inhibit MAP3K1 signaling.
Both the MEKK1 (show MAP2K1 ELISA Kits) PHD (show PDC ELISA Kits) and TAB1 (show TAB1 ELISA Kits) are critical for ES-cell differentiation
Results suggest that proto-oncogene (show RAB1A ELISA Kits) protiins c-Jun (show JUN ELISA Kits) and mitogen-activated protein 3 (show HSPB3 ELISA Kits) kinase 1 (MAP3K1) represent parallel pathways in the control of eyelid closure.
Aberrant expression of Map3k1 enabled growth factor-autonomous proliferation and drove BRAF (show BRAF ELISA Kits)-independent ERK (show EPHB2 ELISA Kits) signaling, thus shedding light on alternative means of activating this prominent signaling pathway in melanoma.
analysis of the gene expression program of MAP3K1 in mouse eyelid morphogenesis
Proximal to the RING domain is a SWIM (SWI2/SNF2 (show SMARCA4 ELISA Kits) and MuDR) domain. The MEKK1 (show MAP2K1 ELISA Kits) SWIM domain, but not the RING domain, directly associates with the c-Jun (show JUN ELISA Kits) DNA-binding domain, and the SWIM domain is required for MEKK1 (show MAP2K1 ELISA Kits)-dependent c-Jun (show JUN ELISA Kits) ubiquitylation.
MAP3K1 is the nexus of an intracrine regulatory loop connecting the TGF-alpha (show TGFA ELISA Kits)/EGFR (show EGFR ELISA Kits)/RhoA (show RHOA ELISA Kits)-c-Jun (show JUN ELISA Kits) and JNK-c-Jun-AP-1 (show JUN ELISA Kits) pathways in developmental eyelid closure.
MAP3K1 is not required for mouse testis determination
double mekk1/camta3 mutant positioned CAMTA3 downstream of MEKK1 and verified their distinct roles in GSR (show GSR ELISA Kits) regulation. mekk1-5 displays programmed cell death and overaccumulates reactive oxygen species and salicylic acid
Treatment of Arabidopsis with a membrane rigidifier, DMSO, causes MPK4 (show MAPK4 ELISA Kits) activation concomitantly with MEKK1 and MKK2 (show MAP2K2 ELISA Kits) phosphorylation.
Ca(2 (show CA2 ELISA Kits)+) signaling occurred upstream of the MEKK1-MKK2 (show MAP2K2 ELISA Kits) pathway. MEKK1 was phosphorylated by calcium/calmodulin (show CALM ELISA Kits)-regulated receptor-like kinase (CRLK1), which suggested that CRLK1 is one of candidates located upstream of MEKK1.
MEKK1 plays a key role in transducing the l-Glu (show DCTN1 ELISA Kits) signal that elicits large-scale changes in root architecture, and provide genetic evidence for the existence in plants of an external glutamate (show GRIN2A ELISA Kits) (l-Glu (show DCTN1 ELISA Kits)) signalling pathway analogous to that found in animals.
Data indicate that MEKK2 (show MAP3K2 ELISA Kits) is required for the mekk1, mkk1 (show MAP2K1 ELISA Kits) mkk2 (show MAP2K2 ELISA Kits), and mpk4 (show MAPK4 ELISA Kits) autoimmune phenotypes.
Data suggest that the MEKK1-MKK1 (show MAP2K1 ELISA Kits)/MKK2 (show MAP2K2 ELISA Kits)-MPK4 (show MAPK4 ELISA Kits) kinase cascade negatively regulates MEKK2 (show MAP3K2 ELISA Kits) and activation of MEKK2 (show MAP3K2 ELISA Kits) triggers SUMM2-mediated immune responses.
CRLK1 interacts with MEKK1 in vitro and in planta during cold treatment.
An analysis of the interation of MEKK1 and MEK1 (show MAP2K1 ELISA Kits) in response to wounding stress in A. thaliana seedlings is presented.
MEKK1 is essential for activation of MPK4 and negatively regulates temperature-sensitive and tissue-specific cell death and H(2)O(2) accumulation that are dependent on both RAR1 (resistance protein function) and SID2 (isochorismate synthase)
This study demonstrated that analysis of plants carrying T-DNA knockout alleles indicated that MEKK1 is required for flg22-induced activation of MPK4 (show MAPK4 ELISA Kits).
CSN6 (show COPS6 ELISA Kits) positively regulates c-Jun (show JUN ELISA Kits) in a MEKK1-dependent manner
Mekk1 mediates p53 protein stability in the presence of Mdm2 and reduces p53 ubiquitination, suggesting an interference with Mdm2-mediated degradation of p53 by the ubiquitin-proteasome pathway.
BAALC conferred chemoresistance in acute myeloid leukemia (show BCL11A ELISA Kits) cells by upregulating ATP-binding cassette proteins in an ERK (show EPHB2 ELISA Kits)-dependent manner, which can be therapeutically targeted by MEK (show MAP2K1 ELISA Kits) inhibitor
MiR (show MLXIP ELISA Kits)-451 inhibited the proliferation of esophageal squamous cell carcinoma cells by targeting CDKN2D (show CDKN2D ELISA Kits) and MAP3K1 expression.
There were 3 specimens with mutations in MAP3K1 (MEKK1), including two truncation mutants, T779fs and T1481fs; T1481fs encoded an unstable and nonfunctional protein when expressed in vitro.
Single nucleotide polymorphisms in ALDOB (show ALDOB ELISA Kits), MAP3K1, and MEF2C (show MEF2C ELISA Kits) are associated with cataract.
Results demonstrate that MAP3K1 rs889312 is closely correlated with outcome among diffuse-type gastric cancer in a Chinese population.
We propose that the cancer risk alleles act to increase MAP3K1 expression in vivo and might promote breast cancer cell survival.
The present meta-analysis suggests that MAPKKK1 rs889312-C allele and rs16886165-G allele might be risk factors for breast cancer, especially in Europeans and Asians.
MAP3K1 mutations tilt the balance in the sex-determining pathways by downregulating SOX9 and FGF9.
The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus.
mitogen-activated protein kinase kinase kinase 1
, MAPK/ERK kinase kinase 1
, MEK kinase 1
, MEKK 1
, mitogen activated protein kinase kinase kinase 1
, MAP/ERK kinase kinase 1