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let-7g induces porcine granulosa cells apoptosis by inhibiting the MAP3K1 gene, which promotes FoxO1 (show FOXO1 Proteins) expression and dephosphorylation with nuclear accumulation.
goya and kinase-deficient Map3k1 homozygotes initially develop supernumerary cochlear outer hair cells (OHCs) that subsequently degenerate.
These data highlight the crucial role of MAP3K1 in the development and function of the mouse inner ear and hearing.
Dioxin exposure markedly inhibited c-Jun (show JUN Proteins) phosphorylation in Map3k1-deficient embryonic eyelid epithelium, suggesting that dioxin-induced AHR (show AHR Proteins) pathways can synergize with gene mutations to inhibit MAP3K1 signaling.
Both the MEKK1 (show MAP2K1 Proteins) PHD (show PDC Proteins) and TAB1 (show TAB1 Proteins) are critical for ES-cell differentiation
Results suggest that proto-oncogene (show RAB1A Proteins) protiins c-Jun (show JUN Proteins) and mitogen-activated protein 3 (show HSPB3 Proteins) kinase 1 (MAP3K1) represent parallel pathways in the control of eyelid closure.
Aberrant expression of Map3k1 enabled growth factor-autonomous proliferation and drove BRAF (show BRAF Proteins)-independent ERK (show EPHB2 Proteins) signaling, thus shedding light on alternative means of activating this prominent signaling pathway in melanoma.
analysis of the gene expression program of MAP3K1 in mouse eyelid morphogenesis
Proximal to the RING domain is a SWIM (SWI2/SNF2 (show SMARCA4 Proteins) and MuDR) domain. The MEKK1 (show MAP2K1 Proteins) SWIM domain, but not the RING domain, directly associates with the c-Jun (show JUN Proteins) DNA-binding domain, and the SWIM domain is required for MEKK1 (show MAP2K1 Proteins)-dependent c-Jun (show JUN Proteins) ubiquitylation.
MAP3K1 is the nexus of an intracrine regulatory loop connecting the TGF-alpha (show TGFA Proteins)/EGFR (show EGFR Proteins)/RhoA (show RHOA Proteins)-c-Jun (show JUN Proteins) and JNK-c-Jun-AP-1 (show JUN Proteins) pathways in developmental eyelid closure.
MAP3K1 is not required for mouse testis determination
double mekk1/camta3 mutant positioned CAMTA3 downstream of MEKK1 and verified their distinct roles in GSR (show GSR Proteins) regulation. mekk1-5 displays programmed cell death and overaccumulates reactive oxygen species and salicylic acid
Treatment of Arabidopsis with a membrane rigidifier, DMSO, causes MPK4 (show MAPK4 Proteins) activation concomitantly with MEKK1 and MKK2 (show MAP2K2 Proteins) phosphorylation.
Ca(2 (show CA2 Proteins)+) signaling occurred upstream of the MEKK1-MKK2 (show MAP2K2 Proteins) pathway. MEKK1 was phosphorylated by calcium/calmodulin (show CALM Proteins)-regulated receptor-like kinase (CRLK1), which suggested that CRLK1 is one of candidates located upstream of MEKK1.
MEKK1 plays a key role in transducing the l-Glu (show DCTN1 Proteins) signal that elicits large-scale changes in root architecture, and provide genetic evidence for the existence in plants of an external glutamate (show GRIN2A Proteins) (l-Glu (show DCTN1 Proteins)) signalling pathway analogous to that found in animals.
Data indicate that MEKK2 (show MAP3K2 Proteins) is required for the mekk1, mkk1 (show MAP2K1 Proteins) mkk2 (show MAP2K2 Proteins), and mpk4 (show MAPK4 Proteins) autoimmune phenotypes.
Data suggest that the MEKK1-MKK1 (show MAP2K1 Proteins)/MKK2 (show MAP2K2 Proteins)-MPK4 (show MAPK4 Proteins) kinase cascade negatively regulates MEKK2 (show MAP3K2 Proteins) and activation of MEKK2 (show MAP3K2 Proteins) triggers SUMM2-mediated immune responses.
CRLK1 interacts with MEKK1 in vitro and in planta during cold treatment.
An analysis of the interation of MEKK1 and MEK1 (show MAP2K1 Proteins) in response to wounding stress in A. thaliana seedlings is presented.
MEKK1 is essential for activation of MPK4 and negatively regulates temperature-sensitive and tissue-specific cell death and H(2)O(2) accumulation that are dependent on both RAR1 (resistance protein function) and SID2 (isochorismate synthase)
This study demonstrated that analysis of plants carrying T-DNA knockout alleles indicated that MEKK1 is required for flg22-induced activation of MPK4 (show MAPK4 Proteins).
CSN6 (show COPS6 Proteins) positively regulates c-Jun (show JUN Proteins) in a MEKK1-dependent manner
Mekk1 mediates p53 protein stability in the presence of Mdm2 and reduces p53 ubiquitination, suggesting an interference with Mdm2-mediated degradation of p53 by the ubiquitin-proteasome pathway.
BAALC (show BAALC Proteins) conferred chemoresistance in acute myeloid leukemia (show BCL11A Proteins) cells by upregulating ATP-binding cassette proteins in an ERK (show EPHB2 Proteins)-dependent manner, which can be therapeutically targeted by MEK (show MAP2K1 Proteins) inhibitor
MiR (show MLXIP Proteins)-451 inhibited the proliferation of esophageal squamous cell carcinoma cells by targeting CDKN2D (show CDKN2D Proteins) and MAP3K1 expression.
There were 3 specimens with mutations in MAP3K1 (MEKK1), including two truncation mutants, T779fs and T1481fs; T1481fs encoded an unstable and nonfunctional protein when expressed in vitro.
Single nucleotide polymorphisms in ALDOB (show ALDOB Proteins), MAP3K1, and MEF2C (show MEF2C Proteins) are associated with cataract.
Results demonstrate that MAP3K1 rs889312 is closely correlated with outcome among diffuse-type gastric cancer in a Chinese population.
We propose that the cancer risk alleles act to increase MAP3K1 expression in vivo and might promote breast cancer cell survival.
The present meta-analysis suggests that MAPKKK1 rs889312-C allele and rs16886165-G allele might be risk factors for breast cancer, especially in Europeans and Asians.
MAP3K1 mutations tilt the balance in the sex-determining pathways by downregulating SOX9 and FGF9.
The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus.
mitogen-activated protein kinase kinase kinase 1
, MAPK/ERK kinase kinase 1
, MEK kinase 1
, MEKK 1
, mitogen activated protein kinase kinase kinase 1
, MAP/ERK kinase kinase 1