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Browse our anti-MAP3K4 (MAP3K4) Antibodies

Full name:
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 Antibodies (MAP3K4)
On www.antibodies-online.com are 79 Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) Antibodies from 17 different suppliers available. Additionally we are shipping MAP3K4 Proteins (4) and many more products for this protein. A total of 87 MAP3K4 products are currently listed.
Synonyms:
D17Rp17, D17Rp17e, MAPKKK4, Mek4b, MEKK 4, Mekk4, mKIAA0213, MTK1, PRO0412, RP17, Rp17a, Tas
list all antibodies Gene Name GeneID UniProt
MAP3K4 308106  
MAP3K4 4216 Q9Y6R4
MAP3K4 26407 O08648

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anti-Mouse (Murine) MAP3K4 Antibodies:

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Top referenced anti-MAP3K4 Antibodies

  1. Human Polyclonal MAP3K4 Primary Antibody for EIA, IHC (p) - ABIN953298 : Grucza, Johnson, Krueger, Breslau, Saccone, Chen, Derringer, Agrawal, Lynskey, Bierut: Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes. in Addiction biology 2010 (PubMed)
    Show all 5 references for ABIN953298

  2. Human Monoclonal MAP3K4 Primary Antibody for WB - ABIN393795 : Whitmarsh, Davis: Role of mitogen-activated protein kinase kinase 4 in cancer. in Oncogene 2007 (PubMed)
    Show all 5 references for ABIN393795

More Antibodies against MAP3K4 Interaction Partners

Human Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) interaction partners

  1. IL-21 (show IL17C Antibodies) expression is promoted by MEKK4 in malignant T cells and is associated with progression risk in cutaneous T-cell lymphoma

  2. Mutations in genes such as AKT2 (show AKT2 Antibodies), CCNA1 (show CCNA1 Antibodies), MAP3K4, and TGFBR1 (show TGFBR1 Antibodies), were associated significantly with Epstein-Barr-positive gastric tumors, compared with EBV-negative tumors.

  3. Map3k4 haploinsufficiency is the cause of T-associated sex reversal.

  4. MTK1 was identified in the HER2 (show ERBB2 Antibodies)/HER3 (show ERBB3 Antibodies)-HRG (show NRG1 Antibodies) mediated extracellular acidification and cell migration pathway in breast cancer cells.

  5. MAP3K4 is sufficiently mediate the TGFbeta (show TGFB1 Antibodies)-induced phosphorylation of p38 MAPK (show MAPK14 Antibodies) in MEFs and HaCaT cells.

  6. we have identified a reduced IL-1A (show IL1A Antibodies) response, related to a low MAP3K4 expression and high expression of its inhibitor GSK3beta (show GSK3b Antibodies), identifying a novel key player in Crohn's disease.

  7. For the first time we report a significant association between nicotine dependence and DRD5 (show DRD5 Antibodies), NPY1R (show NPY1R Antibodies) MAP3K4 single nucleotide polymorphism.

  8. The upstream molecule of the TRAIL-induced MAPK (show MAPK1 Antibodies) activation is MEKK (show MAP3K1 Antibodies), as opposed to ASK1 (show MAP3K5 Antibodies), via the mediation of its signal through JNK (show MAPK8 Antibodies)/p38 (show CRK Antibodies) in a caspase-8 (show CASP8 Antibodies)-dependent manner.

  9. CIN85 (show SH3KBP1 Antibodies) binding to a C-terminal motif within hTTP leads to the increased phosphorylation of hTTP, possibly through enhanced association with MEKK4

  10. Axin (show AXIN1 Antibodies) utilizes distinct regions for competitive MEKK1 (show MAP3K1 Antibodies) and MEKK4 binding and JNK (show MAPK8 Antibodies) activation.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) interaction partners

  1. Map3k4 haploinsufficiency is the cause of T-associated sex reversal.

  2. suggest a requirement for GADD45gamma (show GADD45G Antibodies) in promoting MAP3K4-mediated activation of p38 MAPK (show MAPK14 Antibodies) signaling in embryonic gonadal somatic cells for testis determination

  3. MTK1 plays an important role in the regulation of cell death and is also involved in the pathogenesis of heart failure.

  4. During Th1 (show HAND1 Antibodies) differentiation, the GADD45beta (show GADD45B Antibodies)/GADD45gamma (show GADD45G Antibodies)/MEKK4 pathway integrates upstream signals transduced by both T cell receptor and IL12 (show IL12A Antibodies)/STAT4 (show STAT4 Antibodies), leading to augmented interferon-gamma (show IFNG Antibodies) production in a process independent of STAT4 (show STAT4 Antibodies).

  5. MEKK4 plays a critical role in regulating MKK4 (show MAP2K4 Antibodies) activity and apoptotic cell death during neural tube development.

  6. MEKK4 is the MAPK (show MAPK1 Antibodies) kinase kinase for TRAF4 (show TRAF4 Antibodies) regulation of the JNK (show MAPK8 Antibodies) pathway

  7. Hindbrains of exencephalic MEKK4(K1361R) embryos show a striking increase in neuroepithelial cell apoptosis and a dramatic loss of phosphorylation of MKK3 (show MAP2K3 Antibodies) and -6, mitogen-activated protein kinase (show MAPK1 Antibodies) kinases (MKKs (show MKKS Antibodies)) regulated by MEKK4 in the p38 (show CRK Antibodies) pathway.

  8. MEKK4 regulates epithelial-to-mesenchymal transition in the endocardial cushions of the developing heart.

  9. our results demonstrate a link between MEKK4 and filamin-a (show FLNA Antibodies) that impacts neuronal migration initiation

  10. GSK3beta (show GSK3b Antibodies) binding to MEKK4 blocks MEKK4 dimerization that is required for MEKK4 activation, effectively inhibiting MEKK4 stimulation of the JNK (show MAPK8 Antibodies) and p38 MAPK (show MAPK14 Antibodies) pathways

MAP3K4 Antigen Profile

Antigen Summary

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described.

Alternative names and synonyms associated with MAP3K4

  • mitogen activated protein kinase kinase kinase 4 (Map3k4) antibody
  • mitogen-activated protein kinase kinase kinase 4 (MAP3K4) antibody
  • mitogen-activated protein kinase kinase kinase 4 (Map3k4) antibody
  • D17Rp17 antibody
  • D17Rp17e antibody
  • MAPKKK4 antibody
  • Mek4b antibody
  • MEKK 4 antibody
  • Mekk4 antibody
  • mKIAA0213 antibody
  • MTK1 antibody
  • PRO0412 antibody
  • RP17 antibody
  • Rp17a antibody
  • Tas antibody

Protein level used designations for MAP3K4

mitogen-activated protein kinase kinase kinase 4 , MAP three kinase 1 , MAP/ERK kinase kinase 4 , MAPK/ERK kinase kinase 4 , MEK kinase 4 , MEKK 4 , SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of , dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4) , predicted protein of HQ0412 , T-associated sex reversal , mitogen activated protein kinase kinase kinase 4

GENE ID SPECIES
308106 Rattus norvegicus
4216 Homo sapiens
26407 Mus musculus
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