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IL-21 (show IL17C Proteins) expression is promoted by MEKK4 in malignant T cells and is associated with progression risk in cutaneous T-cell lymphoma
Mutations in genes such as AKT2 (show AKT2 Proteins), CCNA1 (show CCNA1 Proteins), MAP3K4, and TGFBR1 (show TGFBR1 Proteins), were associated significantly with Epstein-Barr-positive gastric tumors, compared with EBV-negative tumors.
Map3k4 haploinsufficiency is the cause of T-associated sex reversal.
MTK1 was identified in the HER2 (show ERBB2 Proteins)/HER3 (show ERBB3 Proteins)-HRG (show NRG1 Proteins) mediated extracellular acidification and cell migration pathway in breast cancer cells.
MAP3K4 is sufficiently mediate the TGFbeta (show TGFB1 Proteins)-induced phosphorylation of p38 MAPK (show MAPK14 Proteins) in MEFs and HaCaT cells.
we have identified a reduced IL-1A response, related to a low MAP3K4 expression and high expression of its inhibitor GSK3beta, identifying a novel key player in Crohn's disease.
For the first time we report a significant association between nicotine dependence and DRD5 (show DRD5 Proteins), NPY1R (show NPY1R Proteins) MAP3K4 single nucleotide polymorphism.
The upstream molecule of the TRAIL-induced MAPK (show MAPK1 Proteins) activation is MEKK (show MAP3K1 Proteins), as opposed to ASK1 (show MAP3K5 Proteins), via the mediation of its signal through JNK (show MAPK8 Proteins)/p38 (show CRK Proteins) in a caspase-8 (show CASP8 Proteins)-dependent manner.
CIN85 (show SH3KBP1 Proteins) binding to a C-terminal motif within hTTP leads to the increased phosphorylation of hTTP, possibly through enhanced association with MEKK4
Axin (show AXIN1 Proteins) utilizes distinct regions for competitive MEKK1 (show MAP3K1 Proteins) and MEKK4 binding and JNK (show MAPK8 Proteins) activation.
MAP3K4 activity controls epithelial-to-mesenchymal transition through the ubiquitination and degradation of HDAC6 (show HDAC6 Proteins).
by forming a complex with MEKK4 in skeletal muscle fibers, Gadd45a (show GADD45A Proteins) increases MEKK4 protein kinase (show CDK7 Proteins) activity, which is both sufficient to induce skeletal muscle fiber atrophy and required for Gadd45a (show GADD45A Proteins)-mediated skeletal muscle fiber atrophy.
suggest a requirement for GADD45gamma (show GADD45G Proteins) in promoting MAP3K4-mediated activation of p38 MAPK (show MAPK14 Proteins) signaling in embryonic gonadal somatic cells for testis determination
MTK1 plays an important role in the regulation of cell death and is also involved in the pathogenesis of heart failure.
During Th1 (show HAND1 Proteins) differentiation, the GADD45beta (show GADD45B Proteins)/GADD45gamma (show GADD45G Proteins)/MEKK4 pathway integrates upstream signals transduced by both T cell receptor and IL12 (show IL12A Proteins)/STAT4 (show STAT4 Proteins), leading to augmented interferon-gamma (show IFNG Proteins) production in a process independent of STAT4 (show STAT4 Proteins).
MEKK4 plays a critical role in regulating MKK4 (show MAP2K4 Proteins) activity and apoptotic cell death during neural tube development.
MEKK4 is the MAPK (show MAPK1 Proteins) kinase kinase for TRAF4 (show TRAF4 Proteins) regulation of the JNK (show MAPK8 Proteins) pathway
Hindbrains of exencephalic MEKK4(K1361R) embryos show a striking increase in neuroepithelial cell apoptosis and a dramatic loss of phosphorylation of MKK3 (show MAP2K3 Proteins) and -6, mitogen-activated protein kinase (show MAPK1 Proteins) kinases (MKKs (show MKKS Proteins)) regulated by MEKK4 in the p38 (show CRK Proteins) pathway.
MEKK4 regulates epithelial-to-mesenchymal transition in the endocardial cushions of the developing heart.
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described.
mitogen-activated protein kinase kinase kinase 4
, MAP three kinase 1
, MAP/ERK kinase kinase 4
, MAPK/ERK kinase kinase 4
, MEK kinase 4
, MEKK 4
, SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of
, dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4)
, predicted protein of HQ0412
, T-associated sex reversal
, mitogen activated protein kinase kinase kinase 4