anti-Human MAP3K5 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended MAP3K5 Antibody (supplied by: Log in to see )

Antigen
Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) Antibodies
  • 7420452D20Rik
  • ASK
  • ASK1
  • MAPKKK5
  • Mekk5
  • mitogen-activated protein kinase kinase kinase 5
  • MUD21.11
  • MUD21_11
  • MEKK5
  • MAP3K5
  • mitogen-activated protein kinase kinase kinase 5
  • Map3k5
  • MAPKKK5
  • MAP3K5
Epitope
AA 825-875, pThr845
72
59
37
19
19
15
14
14
14
13
10
7
6
6
5
5
4
4
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
400
171
97
6
1
1
1
1
1
1
Host
Rabbit
379
27
Clonality
Polyclonal
Conjugate
This MAP3K5 antibody is un-conjugated
12
12
11
6
6
6
5
5
5
5
5
5
5
5
5
5
5
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
304
160
134
81
64
43
21
13
12
10
4
3
2
1
1
Options
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Catalog No. ABIN683128
$ 329.45
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
11.569977 ABIN461897 ICC IHC (p) ELISA WB Rabbit C-Term Log in to see Polyclonal
11.569977 ABIN498823 IHC (p) Rabbit pSer966 Log in to see Polyclonal
11.569977 ABIN498822 IHC (p) WB Rabbit pSer83 Log in to see Polyclonal
11.569977 ABIN498913 IHC (p) Rabbit Log in to see Polyclonal
11.569977 ABIN498912 IHC (p) Rabbit Log in to see Polyclonal
11.569977 ABIN615252 EIA IF IHC (p) WB Rabbit C-Term Log in to see Polyclonal
11.569977 ABIN461898 IHC (p) ELISA WB Rabbit N-Term Log in to see Polyclonal
11.569977 ABIN615253 EIA IHC (p) WB Rabbit N-Term Log in to see Polyclonal
11.569977 ABIN682798 IF (p) IHC (p) WB Rabbit IgG pSer966 Log in to see Polyclonal
11.569977 ABIN683098 IF (p) IHC (p) WB Rabbit IgG pSer967 Log in to see Polyclonal
11.569977 ABIN5075148 IHC (p) Rabbit IgG Log in to see Polyclonal
11.569977 ABIN5075149 IHC (p) Rabbit IgG Log in to see Polyclonal
11.569977 ABIN4281871 IHC IHC (p) IP WB Rabbit Log in to see Polyclonal
11.569977 ABIN4281873 IHC IHC (p) WB Rabbit Log in to see Polyclonal
11.569977 ABIN4281874 IHC IHC (p) WB Rabbit pSer83 Log in to see Polyclonal
11.569977 ABIN4281872 IHC IHC (p) WB Rabbit Log in to see Polyclonal
1 ABIN196912 IHC (p) WB Rabbit pSer83 Log in to see Polyclonal 2
1 ABIN196914 IHC (p) WB Rabbit pSer966 Log in to see Polyclonal 4
1 ABIN197310 IF IHC (p) WB Rabbit Ser83 Log in to see Polyclonal 3
1 ABIN197326 IF IHC (p) WB Rabbit Ser966 Log in to see Polyclonal 4

General

Antigen Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) Antibodies
Epitope AA 825-875, pThr845
(72), (59), (37), (19), (19), (15), (14), (14), (14), (13), (10), (7), (6), (6), (5), (5), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine)
(400), (171), (97), (6), (1), (1), (1), (1), (1), (1)
Host Rabbit
(379), (27)
Clonality
Polyclonal
Conjugate This MAP3K5 antibody is un-conjugated
(12), (12), (11), (6), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(304), (160), (134), (81), (64), (43), (21), (13), (12), (10), (4), (3), (2), (1), (1)
Pubmed 1 reference available
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Product Details anti-MAP3K5 Antibody

Target Details MAP3K5 Application Details Handling ProductDetails: References for anti-MAP3K5 antibody (ABIN683128) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from mouse ASK1 around the phosphorylation site of Thr845
Isotype IgG

Target Details MAP3K5

Product Details anti-MAP3K5 Antibody Application Details Handling ProductDetails: References for anti-MAP3K5 antibody (ABIN683128) Images back to top
Antigen
Alternative Name Ask1 (MAP3K5 Antibody Abstract)
Background

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).

Subcellular location: Cytoplasm

Synonyms: ASK, ASK1, Mekk5, MAPKKK5, 742452D2Rik, Mitogen-activated protein kinase kinase kinase 5, Apoptosis signal-regulating kinase 1, ASK-1, MAPK/ERK kinase kinase 5, MEK kinase 5, MEKK 5, Map3k5

Gene ID 26408
UniProt O35099
Research Area Cardiovascular, Hypertrophy, Apoptosis/Necrosis
Pathways MAPK Signaling, Positive Regulation of Endopeptidase Activity

Application Details

Product Details anti-MAP3K5 Antibody Target Details MAP3K5 Handling ProductDetails: References for anti-MAP3K5 antibody (ABIN683128) Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-MAP3K5 Antibody Target Details MAP3K5 Application Details ProductDetails: References for anti-MAP3K5 antibody (ABIN683128) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

ProductDetails: References for anti-MAP3K5 antibody (ABIN683128)

Product Details anti-MAP3K5 Antibody Target Details MAP3K5 Application Details Handling Images back to top
Product cited in:

Taniuchi, Furihata, Hanazaki, Iwasaki, Tanaka, Shimizu, Saito, Saibara: "Peroxiredoxin 1 Promotes Pancreatic Cancer Cell Invasion by Modulating p38 MAPK Activity." in: Pancreas, Vol. 44, Issue 2, pp. 331-40, 2015

Images

Product Details anti-MAP3K5 Antibody Target Details MAP3K5 Application Details Handling ProductDetails: References for anti-MAP3K5 antibody (ABIN683128) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) (AA 825-875), (pThr845) antibody (ABIN683128) Formalin-fixed and paraffin embedded rat heart tissue labeled with Anti-phospho-ASK1(...
SDS-PAGE (SDS) image for anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) (AA 825-875), (pThr845) antibody (ABIN683128) L1 rat heart, L2 rat brain lysates probed (ABIN683128) at 1:200 in 4 °C. Followed by ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) (AA 825-875), (pThr845) antibody (ABIN683128) Formalin-fixed and paraffin embedded rat heart tissue labeled with Anti-phospho-ASK1(...