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|Antigen||Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This MAP3K5 antibody is conjugated to Alexa Fluor 594 Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
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Product Details anti-MAP3K5 AntibodyTarget Details MAP3K5 Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic phosphopeptide derived from human ASK1 around the phosphorylation site of Ser1033|
Target Details MAP3K5Product Details anti-MAP3K5 Antibody Application Details Handling Images back to top
|Alternative Name||ASK1 (MAP3K5 Antibody Abstract)|
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells, MAPKKK5 does not activate MAPK/ERK.
Synonyms: ASK1 phospho S1033, Mitogen-activated protein kinase kinase kinase 5, MAPK/ERK kinase kinase 5, MEK kinase 5, MEKK 5, Apoptosis signal-regulating kinase 1, ASK-1, MAP3K5, ASK1, MAPKKK5, MEKK5, M3K5_HUMAN.
|Research Area||Cardiovascular, Hypertrophy, Apoptosis/Necrosis|
|Pathways||MAPK Signaling, Positive Regulation of Endopeptidase Activity, Unfolded protein response|
Application DetailsProduct Details anti-MAP3K5 Antibody Target Details MAP3K5 Handling Images back to top
|Application Notes||IF(IHC-P) 1:50-200|
|Restrictions||For Research Use only|
HandlingProduct Details anti-MAP3K5 Antibody Target Details MAP3K5 Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store at 4°C|
|Expiry Date||12 months|