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anti-Human MAP4K3 Antibodies:
anti-Mouse (Murine) MAP4K3 Antibodies:
anti-Rat (Rattus) MAP4K3 Antibodies:
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Human Polyclonal MAP4K3 Primary Antibody for EIA, IHC (p) - ABIN360428
Diener, Wang, Chen, Meyer, Keesler, Zukowski, Tan, Yao: Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. in Proceedings of the National Academy of Sciences of the United States of America 1997
Human Polyclonal MAP4K3 Primary Antibody for FACS, IHC (p) - ABIN953301
Yan, Mieulet, Burgess, Findlay, Sully, Procter, Goris, Janssens, Morrice, Lamb: PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR. in Molecular cell 2010
ITGB3 (show ITGB3 Antibodies) and MAP4K3 are directly repressed by let-7c, altering the metastatic potential of lung cancer cells.
MAP4K3 expression is required for leucine-induced mTORC1 activation in human primary fibroblasts.
Significantly higher median frequencies of circulating GLK (show GCK Antibodies)-expressing T-cells were observed in patients with adult-onset Still's disease (31.85%) than in healthy volunteers (8.93%, P <0.001).
Amino acid sufficiency phosphorylates MAP4K3/Ser170, activating mTORC1, but amino acid restriction causes MAP4K3 to interact with PP2A (show PPP2R4 Antibodies)(T61 epsilon), promoting dephosphorylation of Ser170, MAP4K3 inhibition, and, inhibition of mTORC1 signaling.
MAP4K3 orchestrates activation of BAX (show BAX Antibodies) via the concerted posttranscriptional modulation of PUMA (show BBC3 Antibodies), BAD, and BIM (show BCL2L11 Antibodies).
This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.
MAPK/ERK kinase kinase kinase 3
, MEK kinase kinase 3
, germinal center kinase-like kinase
, germinal center kinase-related protein kinase
, MEKKK 3
, mitogen activated protein kinase kinase kinase kinase 3