Browse our MAP4K3 Proteins (MAP4K3)

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Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3 Proteins (MAP4K3)
On are 3 Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3 (MAP4K3) Proteins from 2 different suppliers available. Additionally we are shipping MAP4K3 Antibodies (79) and many more products for this protein. A total of 85 MAP4K3 products are currently listed.
4833416M01Rik, 4833416M07Rik, 9530052P13Rik, Glk, MAPKKKK3, MEKKK3, MEKKK 3, RAB8IPL1
list all proteins Gene Name GeneID UniProt
MAP4K3 8491 Q8IVH8
MAP4K3 225028  
Rat MAP4K3 MAP4K3 170920 Q924I2

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More Proteins for MAP4K3 Interaction Partners

Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3 (MAP4K3) interaction partners

  1. This report details the first structure of GLK (show GCK Proteins); comparison of its activation loop sequence and P-loop structure to that of Map4k4 (show MAP4K4 Proteins) suggests ideas for designing inhibitors that can distinguish between these family members to achieve selective pharmacological inhibitors.

  2. ITGB3 (show ITGB3 Proteins) and MAP4K3 are directly repressed by let-7c, altering the metastatic potential of lung cancer cells.

  3. MAP4K3 expression is required for leucine-induced mTORC1 activation in human primary fibroblasts.

  4. Significantly higher median frequencies of circulating GLK (show GCK Proteins)-expressing T-cells were observed in patients with adult-onset Still's disease (31.85%) than in healthy volunteers (8.93%, P <0.001).

  5. Amino acid sufficiency phosphorylates MAP4K3/Ser170, activating mTORC1, but amino acid restriction causes MAP4K3 to interact with PP2A (show PPP2R4 Proteins)(T61 epsilon), promoting dephosphorylation of Ser170, MAP4K3 inhibition, and, inhibition of mTORC1 signaling.

  6. MAP4K3 orchestrates activation of BAX (show BAX Proteins) via the concerted posttranscriptional modulation of PUMA (show BBC3 Proteins), BAD, and BIM (show BCL2L11 Proteins).

MAP4K3 Protein Profile

Protein Summary

This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with MAP4K3

  • mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3)
  • mitogen-activated protein kinase kinase kinase kinase 3 (Map4k3)
  • 4833416M01Rik protein
  • 4833416M07Rik protein
  • 9530052P13Rik protein
  • Glk protein
  • MAPKKKK3 protein
  • MEKKK3 protein
  • MEKKK 3 protein
  • RAB8IPL1 protein

Protein level used designations for MAP4K3

MAPK/ERK kinase kinase kinase 3 , MEK kinase kinase 3 , germinal center kinase-like kinase , germinal center kinase-related protein kinase , MEKKK 3 , mitogen activated protein kinase kinase kinase kinase 3 , GLK

8491 Homo sapiens
225028 Mus musculus
170920 Rattus norvegicus
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