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|Antigen||Mitogen-Activated Protein Kinase 10 (MAPK10) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This MAPK10 antibody is conjugated to Cy3 Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
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Product Details anti-MAPK10 AntibodyTarget Details MAPK10 Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human JNK3/MAPK10|
Target Details MAPK10Product Details anti-MAPK10 Antibody Application Details Handling Images back to top
|Alternative Name||Jnk3 (MAPK10 Antibody Abstract)|
MAPK10 (JNK3) is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuron-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways of neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 (CDK5) can phosphorylate and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Synonyms: cJun N terminal kinase 3, MAP kinase p49 3F12, Stress activated protein kinase JNK3, c Jun kinase 3, JNK3, JNK3A, MAP kinase, mitogen activated protein kinase 10, p493F12, p54bSAPK, PRKM10, protein kinase mitogen activated 10 , stress activated protein kinase beta.
|Pathways||MAPK Signaling, WNT Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades|
Application DetailsProduct Details anti-MAPK10 Antibody Target Details MAPK10 Handling Images back to top
|Application Notes||IF(IHC-P) 1:50-200|
|Restrictions||For Research Use only|
HandlingProduct Details anti-MAPK10 Antibody Target Details MAPK10 Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at 4°C|
|Expiry Date||12 months|