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Human MAPK13 Protein expressed in Baculovirus infected Insect Cells - ABIN2003339
Loesch, Chen: The p38 MAPK stress pathway as a tumor suppressor or more? in Frontiers in bioscience : a journal and virtual library 2008
Show all 3 references for ABIN2003339
Human MAPK13 Protein expressed in Escherichia coli (E. coli) - ABIN667604
Nishida, Gotoh: The MAP kinase cascade is essential for diverse signal transduction pathways. in Trends in biochemical sciences 1993
Show all 2 references for ABIN667604
AtMKK6-AtMPK13 module positively regulates lateral root formation.[AtMPK13]
MAPK13 gene knockdown using siRNA reduced the aldehyde dehydrogenase high cell population and abrogated the tumor-initiating ability.
p38gamma and p38delta reprogram liver metabolism by modulating neutrophil infiltration and provide a potential target for NAFLD therapy
MAPK13 undergoes a larger interlobe configurational rearrangement upon activation compared with MAPK14 (show MAPK14 Proteins).
PKCdelta (show PKCd Proteins) activates a MEKK1 (show MAP3K1 Proteins)/MEK3 (show MAP2K3 Proteins)/p38delta MAPK (show MAPK1 Proteins) cascade to increase p53 (show TP53 Proteins) levels and p53 (show TP53 Proteins) drives p21(Cip1 (show CDKN1A Proteins)) gene expression.
esophageal squamous cell carcinoma cell lines which are p38delta-negative grew more quickly than cell lines which express endogenous p38delta.
DNA methylation alterations are widespread in melanoma; epigenetic silencing of MAPK13 contributes to melanoma progression
Data indicate that p38delta mediates oncogene-induced senescence through a p53- and p16(INK4A)-independent mechanism.
GSK3alpha, GSK3beta, and MAPK13 were found to be the most active tau kinases, phosphorylating tau at all four epitopes.
MAPK13 is responsible for IL-13 (show IL13 Proteins)-driven mucus production in human airway epithelial cells.
SEPW1 (show SEPW1 Proteins) silencing increases MKK4 (show MAP2K4 Proteins), which activates p38gamma (show MAPK12 Proteins), p38delta, and JNK2 (show MAPK9 Proteins) to phosphorylate p53 (show TP53 Proteins) on Ser (show SIGLEC1 Proteins)-33 and cause a transient G(1) arrest.
Results reveal that p38delta contributes both cell-autonomous and paracrine effects during the course of skin tumor formation.
p38gamma (show MAPK12 Proteins) and p38delta control heart growth by modulating mTOR (show FRAP1 Proteins) pathway through DEPTOR (show DEPTOR Proteins) phosphorylation and subsequent degradation.
Together, our results establish that p38gamma (show MAPK12 Proteins) and p38delta are central to colitis-associated colon cancer formation through regulation of hematopoietic cell response to injury, and validate p38gamma (show MAPK12 Proteins) and p38kappa as potential targets for cancer therapy.
p38gamma and p38delta are crucial regulators of inflammatory joint destruction in collagen-induced arthritis.
p27 inhibition of COX-2 expression was specifically due to phosphorylation of transcription factor cAMP response element binding (CREB) phosphorylation mediated by p38beta and p38delta.
Aberrant p38delta-PKD1 (show PKD1 Proteins) signaling in neutrophils may underlie development of acute lung injury and life-threatening acute respiratory distress syndrome.
p38gamma (show MAPK12 Proteins) and p38delta kinases regulate the Toll-like receptor 4 (TLR4 (show TLR4 Proteins))-induced cytokine production by controlling ERK1/2 protein kinase (show CDK7 Proteins) pathway activation
results indicate that p38gamma and p38delta have a role in the suppression of tumor development
This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene.
MAP kinase 13
, MAPK 13
, MAP kinase p38 delta
, mitogen-activated protein kinase p38 delta
, stress-activated protein kinase 4
, SAPK/Erk/kinase 4
, mitogen activated protein kinase 13
, p38 delta MAP kinase
, mitogen-activated protein kinase 13