anti-Human MAPK9 antibody for Immunoprecipitation

Recommended MAPK9 Antibody (supplied by: Log in to see )

Antigen
Mitogen-Activated Protein Kinase 9 (MAPK9) Antibodies
  • MAPK9
  • JNK-55
  • JNK2
  • JNK2A
  • JNK2ALPHA
  • JNK2B
  • JNK2BETA
  • PRKM9
  • SAPK
  • SAPK1a
  • p54a
  • p54aSAPK
  • AI851083
  • Prkm9
  • JNK2-ALPHA1
  • MAP kinase 9
  • mitogen-activated protein kinase 9
  • MAPK9
  • Mapk9
  • MPK9
Epitope
AA 1-424
24
16
15
14
13
11
9
9
8
7
6
5
5
5
5
5
3
1
1
1
1
1
1
1
1
Reactivity
Human
189
82
62
19
11
8
7
5
4
3
2
2
2
2
1
1
1
1
Host
Rabbit
120
42
22
4
1
Clonality
Polyclonal
Conjugate
This MAPK9 antibody is un-conjugated
6
5
3
3
3
3
Application
Immunoprecipitation (IP), ELISA
177
90
61
43
28
20
10
7
7
2
1
1
1
1
1
1
Supplier
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Catalog No. ABIN1997379
$ 218.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN1997369 IP ELISA WB Mouse IgG2b AA 1-424 Log in to see 3C3C12E5
1 ABIN1821866 ICC IP IHC WB Rabbit IgG pThr183 Log in to see Polyclonal
1 ABIN1997375 ELISA IF IF/ICC IHC (p) IP WB Rabbit IgG AA 1-424 Log in to see 011
1 ABIN1997373 ELISA IF IF/ICC IP WB Rabbit IgG AA 1-424 Log in to see 004
1 ABIN1873633 ICC IF IHC IP WB Rabbit IgG Log in to see Polyclonal
1 ABIN4327967 ICC IF IHC IP WB Rabbit pThr183, pTyr185 Log in to see Polyclonal
1 ABIN1859759 ICC IHC IP WB Rabbit IgG AA 130-387 Log in to see Polyclonal
1 ABIN2882061 ICC IF IHC IP WB Rabbit IgG Log in to see Polyclonal
1 ABIN2404166 ICC IF IP IHC WB Rabbit IgG Log in to see Polyclonal
1 ABIN5583103 IHC IP WB Rabbit pThr183, pTyr185 Log in to see Polyclonal
1 ABIN2959788 IP WB Mouse IgG2 full length Log in to see 2G12
1 ABIN2698433 IC IF IP IHC WB Rabbit IgG Log in to see Polyclonal
1 ABIN2682325 IP ELISA Rabbit IgG AA 1-424 Log in to see Polyclonal
1 ABIN5621382 ICC IHC IP WB Rabbit pThr183, pTyr185 Log in to see Polyclonal
1 ABIN2293918 IP WB Rabbit IgG Log in to see 5i115
1 ABIN2989604 IF/ICC IHC IP WB Rabbit IgG Log in to see Polyclonal
1 ABIN5558211 ELISA IHC IP WB FITC Chicken Log in to see Polyclonal
1 ABIN5558210 ELISA IHC IP WB Biotin Chicken Log in to see Polyclonal
1 ABIN5558209 ELISA IHC IP WB Chicken Log in to see Polyclonal

General

Antigen Mitogen-Activated Protein Kinase 9 (MAPK9) Antibodies
Epitope AA 1-424
(24), (16), (15), (14), (13), (11), (9), (9), (8), (7), (6), (5), (5), (5), (5), (5), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(189), (82), (62), (19), (11), (8), (7), (5), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Host Rabbit
(120), (42), (22), (4), (1)
Clonality
Polyclonal
Conjugate This MAPK9 antibody is un-conjugated
(6), (5), (3), (3), (3), (3)
Application Immunoprecipitation (IP), ELISA
(177), (90), (61), (43), (28), (20), (10), (7), (7), (2), (1), (1), (1), (1), (1), (1)
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Product Details anti-MAPK9 Antibody

Target Details MAPK9 Application Details Handling Images
Specificity Human JNK2 / MAPK9
Characteristics Produced in rabbits immunized with purified, recombinant Human JNK2 / MAPK9 (rh JNK2 / MAPK9, ABIN2003338 NP_002743.3, Met 1-Arg 424,. JNK2 / MAPK9 specific IgG was purified by Human JNK2 / MAPK9 affinity chromatography.
Purification purified by affinity chromatography
Sterility 0.2 μm filtered
Immunogen Recombinant Human JNK2 proteimn (ABIN2003338)
Isotype IgG

Target Details MAPK9

Product Details anti-MAPK9 Antibody Application Details Handling Images back to top
Antigen
Alternative Name MAPK9 (MAPK9 Antibody Abstract)
Background Mitogen-activated protein kinase 9 (MAPK9), also well known as c-Jun N-terminal kinase (JNK2), is a member of MAP kinase subfamily belonging to the protein kinase superfamily. MAPK9 responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, such as c-Jun and ATF2. The crystal structure of human JNK2 complexed with an indazole inhibitor by applying a high-throughput protein engineering and surface-site mutagenesis approach. A novel conformation of the activation loop is observed, which is not compatible with its phosphorylation by upstream kinases. This activation inhibitory conformation of JNK2 is stabilized by the MAP kinase insert that interacts with the activation loop in an induced-fit manner. It suggest that the MAP kinase insert of JNK2 plays a role in the regulation of JNK2 activation, possibly by interacting with intracellular binding partners. JNK2 deficiency leads to reduced c-Jun degradation, thereby augmenting c-Jun levels and cellular proliferation, and suggests that JNK2 is a negative regulator of cellular proliferation in multiple cell types. JNK2 prevents replicative stress by coordinating cell cycle progression and DNA damage repair mechanisms. JNK2 blocks the ubiquitination of tumor suppressor p53, and thus increases the stability of p53 in nonstressed cells. JNK2 negatively regulates antigen-specific CD8+ T cell expansion and effector function, and thus selectively blocking JNK2 in CD8+ T cells may potentially enhance anti-tumor immune response. Lack of JNK2 expression was associated with higher tumor aneuploidy and reduced DNA damage response. Additionally,the JNK2 protein could be a novel therapeutic target in dry eye disease, and may provide a novel target for prevention of vascular disease and atherosclerosis.
NCBI Accession NP_002743.3
Pathways MAPK Signaling, WNT Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, Toll-Like Receptors Cascades

Application Details

Product Details anti-MAPK9 Antibody Target Details MAPK9 Handling Images back to top
Application Notes ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human MAPK9 . The detection limit for Human MAPK9 is approximately 0.00245 ng/well.
IP: 1-4 μg/mg of lysate
Restrictions For Research Use only

Handling

Product Details anti-MAPK9 Antibody Target Details MAPK9 Application Details Images back to top
Format Liquid
Buffer 0.2 μm filtered solution in PBS with 5 % trehalose
Preservative Without preservative
Handling Advice Avoid repeated freeze-thaw cycles.
Storage 4 °C,-20 °C,-80 °C
Storage Comment This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Expiry Date 12 months

Images

Product Details anti-MAPK9 Antibody Target Details MAPK9 Application Details Handling back to top
Supplier Images
Immunoprecipitation (IP) image for anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 1-424) antibody (ABIN1997379) anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 1-424) antibody