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anti-Rat (Rattus) MAPKAP Kinase 2 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended MAPKAP Kinase 2 Antibody (supplied by: Log in to see )

Antigen
Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2) Antibodies
  • AA960234
  • MAPKAP-K2
  • mapkapk2
  • MAPKAPK2
  • MGC78852
  • MK-2
  • MK2
  • Rps6kc1
  • wu:fb30e10
  • wu:fc56c10
  • wu:fi03a01
Epitope
AA 192-230, pThr222
51
24
20
15
13
13
12
11
10
10
8
5
4
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
214
136
107
29
4
2
2
2
1
1
1
Host
Rabbit
191
25
20
Clonality
Polyclonal
Conjugate
This MAPKAP Kinase 2 antibody is un-conjugated
8
8
8
6
5
5
4
4
3
3
3
3
3
3
3
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
173
103
89
32
32
28
25
18
10
4
2
1
1
1
Supplier
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Catalog No. ABIN743678
$ 291.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.34288716 ABIN498988 IHC (p) WB Rabbit Log in to see Polyclonal
0.34288716 ABIN499033 IHC (p) WB Rabbit Log in to see Polyclonal
0.0008982679 ABIN681523 IF (p) IHC (p) WB Rabbit IgG AA 337-363 Log in to see Polyclonal 2
0.0008982679 ABIN197078 IF IHC (p) WB Rabbit pThr334 Log in to see Polyclonal 2
0.0008982679 ABIN272118 IHC (p) WB Rabbit Log in to see Polyclonal
0.0008982679 ABIN743693 IF (p) IHC (p) Rabbit IgG AA 331-334, pThr334 Log in to see Polyclonal
0.0008982679 ABIN681525 IHC (p) WB Biotin Rabbit IgG AA 337-363 Log in to see Polyclonal
0.0008982679 ABIN681532 IHC (p) WB HRP Rabbit IgG AA 337-363 Log in to see Polyclonal
0.0008982679 ABIN743695 IHC (p) Biotin Rabbit IgG AA 331-334, pThr334 Log in to see Polyclonal
0.0008982679 ABIN743687 IHC (p) WB HRP Rabbit IgG AA 192-230, pThr222 Log in to see Polyclonal
0.0008982679 ABIN743702 IHC (p) HRP Rabbit IgG AA 331-334, pThr334 Log in to see Polyclonal
0.0008982679 ABIN743680 IHC (p) WB Biotin Rabbit IgG AA 192-230, pThr222 Log in to see Polyclonal
0.0008982679 ABIN408123 IHC (p) IHC WB Rabbit IgG Log in to see Polyclonal
0.0008982679 ABIN4332688 ICC IF IHC IHC (p) WB Rabbit pThr334 Log in to see Polyclonal
0.0008982679 ABIN2963395 IHC (p) WB Rabbit AA 300-350, Ser328 Log in to see Polyclonal
0.0008982679 ABIN4332689 IHC IHC (p) WB Rabbit Log in to see Polyclonal
0.0008982679 ABIN4332690 IHC IHC (p) WB Rabbit Log in to see Polyclonal

Top referenced anti-MAPKAP Kinase 2 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Similar anti-MAPKAP Kinase 2 Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Rattus) Cow (Bovine)
Western Blotting (WB) 153 Antibodies 97 Antibodies 72 Antibodies 10 Antibodies
Proximity Ligation Assay (PLA) 1 Antibodies
Intracellular Staining (ICS) 4 Antibodies 4 Antibodies
Immunoprecipitation (IP) 18 Antibodies 13 Antibodies 7 Antibodies 4 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 33 Antibodies 18 Antibodies 18 Antibodies 6 Antibodies
Immunohistochemistry (IHC) 89 Antibodies 48 Antibodies 47 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 22 Antibodies

General

Antigen Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2) Antibodies
Epitope AA 192-230, pThr222
(51), (24), (20), (15), (13), (13), (12), (11), (10), (10), (8), (5), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
(214), (136), (107), (29), (4), (2), (2), (2), (1), (1), (1)
Host Rabbit
(191), (25), (20)
Clonality
Polyclonal
Conjugate This MAPKAP Kinase 2 antibody is un-conjugated
(8), (8), (8), (6), (5), (5), (4), (4), (3), (3), (3), (3), (3), (3), (3)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(173), (103), (89), (32), (32), (28), (25), (18), (10), (4), (2), (1), (1), (1)
Pubmed 1 reference available
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Product Details anti-MAPKAP Kinase 2 Antibody

Target Details MAPKAP Kinase 2 Application Details Handling References for anti-MAPKAP Kinase 2 Antibody (ABIN743678) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human MAPKAPK2 around the phosphorylation site of Thr222
Isotype IgG

Target Details MAPKAP Kinase 2

Product Details anti-MAPKAP Kinase 2 Antibody Application Details Handling References for anti-MAPKAP Kinase 2 Antibody (ABIN743678) Images back to top
Antigen
Alternative Name Mapkapk2 (MAPKAPK2 Antibody Abstract)
Background

Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA, HSF1, HSP27/HSPB1, KRT18, KRT2, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA, PABPC1 and TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA and PARN, leading to stabilize GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.

Subcellular location: Cytoplasm, Nucleus


Synonyms: MK2, MK-2, MAPKAP-K2, MAP kinase-activated protein kinase 2, MAPK-activated protein kinase 2, MAPKAP kinase 2, MAPKAPK-2, MAPKAPK2
Gene ID 9261
UniProt P49137
Pathways MAPK Signaling, Neurotrophin Signaling Pathway

Application Details

Product Details anti-MAPKAP Kinase 2 Antibody Target Details MAPKAP Kinase 2 Handling References for anti-MAPKAP Kinase 2 Antibody (ABIN743678) Images back to top
Application Notes WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Restrictions For Research Use only

Handling

Product Details anti-MAPKAP Kinase 2 Antibody Target Details MAPKAP Kinase 2 Application Details References for anti-MAPKAP Kinase 2 Antibody (ABIN743678) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

References for anti-MAPKAP Kinase 2 Antibody (ABIN743678)

Product Details anti-MAPKAP Kinase 2 Antibody Target Details MAPKAP Kinase 2 Application Details Handling Images back to top
Product cited in:

Rosenzweig, Djap, Ou, Quinn: "Mechanical injury of bovine cartilage explants induces depth-dependent, transient changes in MAP kinase activity associated with apoptosis." in: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, Vol. 20, Issue 12, pp. 1591-602, 2012

Images

Product Details anti-MAPKAP Kinase 2 Antibody Target Details MAPKAP Kinase 2 Application Details Handling References for anti-MAPKAP Kinase 2 Antibody (ABIN743678) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-MAPKAP Kinase 2 antibody (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2) (AA 192-230) (ABIN743678) Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-Phospho-...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-MAPKAP Kinase 2 antibody (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2) (AA 192-230) (ABIN743678) Formalin-fixed and paraffin embedded mouse brain labeled with Rabbit Anti-MAPKAPK2 (T...