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a p38 MAPKAPK2 kinase cascade modulates the activity of F-actin at the yolk cell margin circumference allowing the gradual closure of the blastopore as epiboly progresses
MK2 (show KCNA2 ELISA Kits)-activating peptide (MK2 (show KCNA2 ELISA Kits)-AP) blocks the effects of anthrax lethal toxin on endothelial barriers in cultured cells and reduces pulmonary vascular leak in rats.
MK2 (show KCNA2 ELISA Kits) regulates postnatal arteriogenesis by controlling vascular recruitment of monocytes/macrophages in dual manner: regulation of endothelial MCP-1 (show CPT1B ELISA Kits) expression in response to hemodynamic and inflammatory forces as well as MCP-1 (show CPT1B ELISA Kits) dependent monocyte migration
these data suggest there is a sexual dimorphism in MK2 (show KCNA2 ELISA Kits) signaling of osteoclast progenitor cell subpopulations.
Loss of MK2 (show KCNA2 ELISA Kits) effectively blocks bone resorption and prevents the development of postmenopausal bone loss.
This study showed that cmpd28, a Mapkapk2/3 inhibitor, represents a potentially new approach to type 2 diabetes therapy.
Deficiency of MK2 (show KCNA2 ELISA Kits) prevents adverse remodelling and promotes endothelial healing of the arterial wall after injury.
high-fat diet-fed MK2 (show KCNA2 ELISA Kits)-/- mice display decreased glucose tolerance and increased insulin (show INS ELISA Kits) resistance compared to controls. Decreased adipose tissue expression of GLUT4 (show SLC2A4 ELISA Kits) might contribute to this phenotype.
Show a low dose of tumor necrosis factor (TNF (show TNF ELISA Kits)) causes hyperacute mortality via an oxidative stress driven mechanism in MK2 (show KCNA2 ELISA Kits)-deficient mice. In addition, MK2 (show KCNA2 ELISA Kits)-deficient mice were found to be more sensitive to cecal ligation and puncture-induced sepsis.
a key role of MK2 (show KCNA2 ELISA Kits) and FasR in the regulation and limitation of the immune response in the CNS
These data suggest that MK2 (show KCNA2 ELISA Kits) is a key downstream effector of p38 (show CRK ELISA Kits) that can modulate pemphigus vulgaris (show DSG3 ELISA Kits) autoantibody pathogenicity.
MK2 (show KCNA2 ELISA Kits) post-transcriptionally regulates TNF-alpha (show TNF ELISA Kits)-induced ICAM-1 (show ICAM1 ELISA Kits) expression by altering the cytoplasmic localization of HuR (show ELAVL1 ELISA Kits) in human lung microvascular endothelial cells.
MK2 (show KCNA2 ELISA Kits) overexpression is associated with primary liver tumors.
CEP131 is the key regulatory target of MK2 (show KCNA2 ELISA Kits) and 14-3-3 (show YWHAQ ELISA Kits) in centriolar satellite remodeling.
mTOR (show FRAP1 ELISA Kits) controls the senescence-associated secretory phenotype by differentially regulating the translation of the MK2 (show KCNA2 ELISA Kits) (also known as MAPKAPK2).
analysis of signaling cooperation between p38-MAPK (show MAPK14 ELISA Kits)/MAPKAP-2/Hsp27 (show HSPB1 ELISA Kits) and intracellular calcium release in AA-induced HBEC apoptosis
findings reveal MK2 (show KCNA2 ELISA Kits)/MK3 (show KCNA3 ELISA Kits) as crucial stress-responsive kinases that promote autophagy through Beclin 1 (show BECN1 ELISA Kits) S90 phosphorylation
The protein expression of both HMGB1 (show HMGB1 ELISA Kits) and MAPKAPK2 were increased in KLM1-R cells.
Data indicate the binding mode and molecular mechanism of action of MAPK-activated protein kinase-2 (MK2) and inhibitors.
Treatment with MK2 (show KCNA2 ELISA Kits) or p38 (show CRK ELISA Kits) inhibitors blocked human papillomavirus genome amplification, identifying the p38 (show CRK ELISA Kits)/MK2 (show KCNA2 ELISA Kits) pathway as a key regulator of the human papillomavirus life cycle.
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.
MAP kinase-activated protein kinase 2
, betty boop
, mitogen-activated protein kinase-activated protein kinase 2
, MAPK-activated protein kinase 2
, MAPKAP kinase 2
, map kinase activated protein kinase-2