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The natural history of MCRPE is in relation to the role of MAPKAPK3 in BM modeling, vascular endothelial growth factor activity, retinal pigment epithelial responses
A dominant mutation in MAPKAPK3 causes a new retinal dystrophy (show MERTK Proteins) involving Bruch's membrane and retinal pigment epithelium.
MK3 (show KCNA3 Proteins) modulation affects BMI1 (show BMI1 Proteins)-dependent and independent cell cycle check-points
findings reveal MK2 (show KCNA2 Proteins)/MK3 (show KCNA3 Proteins) as crucial stress-responsive kinases that promote autophagy through Beclin 1 (show BECN1 Proteins) S90 phosphorylation
Hepatitis C virus core protein interacted with MAPKAPK3 through amino acid residues 41 to 75 of core and the N-terminal half of kinase domain of MAPKAPK3.
Identified CREB (show CREB1 Proteins) activators MAPKAPK3 and FHL5 (show STXBP2 Proteins) as mediators of intimal hyperplasia in vein graft samples.
A high-resolution (1.9 A) crystal structure of the highly homologous MK3 (show KCNA3 Proteins) in complex with a pharmaceutical lead compound is presented.
In the preconditioned heart, genes for MAPKAP kinase 3 were up-regulated.
3pK is transported to the cytoplasm upon both stress and mitogenic stimulation. While kinetics of nuclear export are similar in both situations, the activation pattern differs substantially.
this study shows that the loss of MK3 (show KCNA3 Proteins) in mast cells decreases the IL-33 (show IL33 Proteins)-induced leukocyte recruitment and the resulting skin inflammation
MK2 (show KCNA2 Proteins)/3 cascade plays a strategic role in controlling synaptic plasticity and cognition.
This study showed that cmpd28, a Mapkapk2 (show MAPKAPK2 Proteins)/3 inhibitor, represents a potentially new approach to type 2 diabetes therapy.
Mk3 (show KCNA3 Proteins)-/- mice, challenged with IAV infection, show a strong shift toward an innate NK cell and adaptive Th1 (show HAND1 Proteins) immune response and a resistance to influenza.
MAPKAPK-3 regulates SERCA2a (show ATP2A2 Proteins) expression and fiber type composition to modulate skeletal muscle and cardiomyocyte function.
Protein kinases MK2 (show KCNA2 Proteins) and MK3 (show KCNA3 Proteins) play critical roles in a mouse model of glomerulonephritis.
MK2 (show KCNA2 Proteins) regulates LPS (show TLR4 Proteins)-induced IFNbeta expression and downstream STAT3 (show STAT3 Proteins) activation as it restrains MK3 (show KCNA3 Proteins) from mediating negative regulatory effects
p38 MAP kinase (show MAPK14 Proteins) and MAPKAP kinases MK2 (show KCNA2 Proteins)/3 cooperatively phosphorylate epithelial keratins.
The swine MAPKAPK3 gene might play an important role in the growth and development differences between mini-type Diannan small-ear pigs and large-type Diannan small-ear pigs.
This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein.
mitogen-activated protein kinase-activated protein kinase 3
, MAP kinase-activated protein kinase 3
, MAP kinase-activated protein kinase 3-like
, MAPK-activated protein kinase 3
, MAPKAP kinase 3
, chromosome 3p kinase
, mitogen activated protein kinase-activated protein kinase 3