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|Antigen||Microtubule-Associated Protein tau (MAPT) Antibodies|
|Reactivity||Chicken, Cow (Bovine), Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This MAPT antibody is un-conjugated Alternatives|
Western Blotting (WB)
|Supplier||Log in to see|
Product Details anti-MAPT AntibodyTarget Details MAPT Application Details Handling Images
|Blocking Peptide||Blocking peptide for this product available: ABIN412930|
The antibody recognizes mainly the truncated Tau (~30 kDa) in sample from human, mouse and rat origins.
Reactivity to other species has not been tested.
|Immunogen||Synthetic peptide surrounding amino acid 395 of rat Tau|
Target Details MAPTProduct Details anti-MAPT Antibody Application Details Handling Images back to top
|Alternative Name||tau (MAPT Antibody Abstract)|
Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyperphosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer's disease. Hyperphosphorylation of Tau is thoμght to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK3. This presents the possibility that miscues in GSK3 signaling contribute to the onset of Alzheimer's disease.
Synonyms: tau , TAU , MAPT , MAPTL , FTDP-17 , MSTD , MGC138549 , PPND , MTBT2
|Research Area||Neurology, Cytoskeleton, Alzheimer's Disease|
|Pathways||MAPK Signaling, Microtubule Dynamics, M Phase, Regulation of Cell Size|
Application DetailsProduct Details anti-MAPT Antibody Target Details MAPT Handling Images back to top
|Application Notes||Western blotting (0.5-4 μg/mL). However, the optimal conditions should be determined individually. Other applications have not been determined. The antibody recognizes mainly the truncated Tau (~30 kDa) in sample from human, mouse and rat origins. Other isoforms of Tau at 35 kDa, 60 kDa and 80 kDa can also be recognized. Reactivity to other species has not been tested.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-MAPT Antibody Target Details MAPT Application Details Images back to top
|Buffer||100 μg (0.5 mg/mL) affinity purified rabbit anti-TAU polyclonal antibody in phosphate-buffered saline (PBS) containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal.|
|Precaution of Use||This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||The antibody solution should be gently mixed before use.|
|Storage Comment||For long-term storage, aliquot and freeze at -70 °C.|
|Expiry Date||12 months|
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