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|Antigen||Microtubule-Associated Protein tau (MAPT) Antibodies|
|Conjugate||This MAPT antibody is un-conjugated Alternatives|
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-MAPT AntibodyTarget Details MAPT Application Details Handling Images
|Specificity||This antibody reacts with Tau in both the phosphorylated and non-phosphorylated form. It recognises an epitope between amino acids 95 - 108 of bovine Tau. It does not react with other Microtubule associated proteins or tubulin.|
|Immunogen||Bovine microtubule associated proteins.|
Target Details MAPTProduct Details anti-MAPT Antibody Application Details Handling Images back to top
|Alternative Name||MAPT / tau (MAPT Antibody Abstract)|
|Background||Tau is a neuronal microtubule associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of Tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate Tau.Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau|
|Pathways||MAPK Signaling, Microtubule Dynamics, M Phase, Regulation of Cell Size|
Application DetailsProduct Details anti-MAPT Antibody Target Details MAPT Handling Images back to top
Western Blot: 1/250 - 1/1000. Immunohistochemistry on frozen and paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MAPT Antibody Target Details MAPT Application Details Images back to top
|Buffer||PBS, pH 7.2 containing 0.09 % Sodium Azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage Comment||Store the antibody at -20 °C. Can be shipped at 2 - 8 °C.|