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|Application / Reactivity||Mouse (Murine)||Human|
|Dot Blot (DB)||2 Antibodies||69 Antibodies|
|ELISA||125 Antibodies||338 Antibodies|
|Enzyme Immunoassay (EIA)||2 Antibodies||14 Antibodies|
|Immunochromatography (IC)||2 Antibodies|
|Immunocytochemistry (ICC)||11 Antibodies|
|Immunofluorescence (IF)||56 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||127 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||26 Antibodies|
|Immunoprecipitation (IP)||12 Antibodies|
|Western Blotting (WB)||398 Antibodies|
|Cellular Assay (CA)||12 Antibodies|
|Flow Cytometry (FACS)||4 Antibodies|
|Immunoassay (IA)||12 Antibodies|
|Antigen||Microtubule-Associated Protein tau (MAPT) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This MAPT antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|4 references available|
|Supplier||Log in to see|
Product Details anti-MAPT AntibodyTarget Details MAPT Application Details Handling References for anti-MAPT Antibody (ABIN357423) Images
|Specificity||This antibody detects TAU at C-term.|
|Purification||Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human TAU.|
Target Details MAPTProduct Details anti-MAPT Antibody Application Details Handling References for anti-MAPT Antibody (ABIN357423) Images back to top
|Alternative Name||MAPT / tau (MAPT Antibody Abstract)|
|Background||The microtubule-associated protein tau (MAPT) gene transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau|
|Molecular Weight||78746 Da|
|Gene ID||4137, 9606|
|Pathways||MAPK Signaling, Microtubule Dynamics|
Application DetailsProduct Details anti-MAPT Antibody Target Details MAPT Handling References for anti-MAPT Antibody (ABIN357423) Images back to top
ELISA 1: 1,000. Western blot 1: 50 - 1: 100. Immunohistochemistry on paraffin sections 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MAPT Antibody Target Details MAPT Application Details References for anti-MAPT Antibody (ABIN357423) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.|
References for anti-MAPT Antibody (ABIN357423)Product Details anti-MAPT Antibody Target Details MAPT Application Details Handling Images back to top
Yoshiyama, Zhang, Bruce et al.: "Reduction of detyrosinated microtubules and Golgi fragmentation are linked to tau-induced degeneration in astrocytes." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 23, Issue 33, pp. 10662-71, 2003 (PubMed).
Yancopoulou, Crowther, Chakrabarti et al.: "Tau protein in frontotemporal dementia linked to chromosome 3 (FTD-3)." in: Journal of neuropathology and experimental neurology, Vol. 62, Issue 8, pp. 878-82, 2003 (PubMed).
Horiguchi, Uryu, Giasson et al.: "Nitration of tau protein is linked to neurodegeneration in tauopathies." in: The American journal of pathology, Vol. 163, Issue 3, pp. 1021-31, 2003 (PubMed).
Kraemer, Zhang, Leverenz et al.: "Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 17, pp. 9980-5, 2003 (PubMed).
ImagesProduct Details anti-MAPT Antibody Target Details MAPT Application Details Handling References for anti-MAPT Antibody (ABIN357423) back to top