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EphrinB ligands B2a and B3b, the Ephb4a (show EPHB4 ELISA Kits) receptor and the Pak2a kinase are required for the development of pharyngeal pouches and the segmentation of the posterior facial skeleton.
Essential in vivo role for betaPix (show ARHGEF7 ELISA Kits) and Pak2a during embryonic development and a previously unrecognized pathway specifically involved in cerebrovascular stabilization. [BetaPix (show ARHGEF7 ELISA Kits) AND Pak2a]
Data provide evidence for a critical function of Pak2 in vascular integrity and demonstrate a severe disease phenotype resulting from loss of Pak2 function.
leukaemic cells explicitly require PAK2 to grow towards an extracellular matrix. PAK2-deficient cells fail to form colonies in methylcellulose and to induce lymphomas in vivo. PAK2 might therefore be the critical isoform in leukaemic cells by controlling tumour growth
Results show that PAK2 kinase plays an alternative anti-apoptotic role, phosphorylating caspase-7 (show CASP7 ELISA Kits) and promoting unfettered cell growth and chemotherapeutic resistance.
We found that overexpression of miR (show MLXIP ELISA Kits)-137 inhibited the proliferation of melanoma cells, which could be phenocopied by knockdown of PAK2 using siRNAs.
PAK2 is a direct effector of TSC1 (show TSC1 ELISA Kits)-TSC2 (show TSC2 ELISA Kits)-RHEB (show RHEB ELISA Kits) signaling and a new target for rational drug therapy in TSC (show SLC12A3 ELISA Kits).
Nef exploits PAK2 in a stepwise mechanism in which its kinase activity cooperates with an adaptor function for the exocyst complex to inhibit host cell actin dynamics.
Cytoplasmic Pak2 may promote cell proliferation in normal endometrium during menstrual cycle.
Further analyses show that HDAC6 (show HDAC6 ELISA Kits) may promote growth of GBM cells through inhibition of SMAD2 (show SMAD2 ELISA Kits) phosphorylation to downregulate p21 (show CDKN1A ELISA Kits)
Pak1 (show PAK1 ELISA Kits) and Pak2 counteract centrosome separation in a kinase-dependent manner.
Findings indicate that repression of microRNA miR (show MLXIP ELISA Kits)-134 and consequent up-regulation of p21-activated kinase 2 (Pak2) might contribute to paclitaxel resistance.
Inhibition of PAK activation at late G2-phase centrosomes caused by Rac1 inactivation coincides with impeded activation of Aurora A (show AURKA ELISA Kits) and the CyclinB (show CCNB1 ELISA Kits)/Cdk1 (show CDK1 ELISA Kits) complex and delayed mitotic entry.
PAK2 acts as a Rac1-dependent negative regulator of neuronal glucose uptake and insulin (show INS ELISA Kits) sensitivity.
These results identify Pak1 (show PAK1 ELISA Kits) and Pak2 as redundant regulators of myoblast differentiation in vitro and in vivo and as components of the promyogenic Ncad (show CDH2 ELISA Kits)/Cdo (show CDO1 ELISA Kits)/Cdc42 (show CDC42 ELISA Kits) signaling pathway.
PAK-mediated phosphorylation of PKD1 at Ser203 triggers its membrane dissociation and subsequent entry into the nucleus, thereby regulating the phosphorylation of PKD1 nuclear targets, including class IIa histone deacetylases.
Data indicate that resveratrol treatment inhibits neuronal glucose uptake via P21-activated kinase 2 (PAK2).
Mechanistic insights into the role of Pak2 in hematopoietic stem cells migration and homing.
Pak2 disruption decreased the survival and proliferation of multicytokine stimulated immature progenitors.
The data suggest that Pak2 controls thymic Natural Killer T-cell development by providing a signal that links Egr2 (show EGR2 ELISA Kits) to induce PLZF, in part by regulating signaling lymphocyte activation molecule (show SLAMF1 ELISA Kits) 6 expression.
In adult endothelial cells, Pak2 depletion leads to severe apoptosis and acute angiogenesis defects, and in adult mice, endothelial Pak2 deletion leads to increased vascular permeability.
Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance
Failure to induce proper actin cytoskeletal remodeling impaired PLCgamma1 and Erk1/2 signaling in the absence of Pak2, uncovering the critical function of Pak2 as an essential regulator that governs the actin cytoskeleton-dependent signaling
Basement membrane proteins promote PAK2 Ser (show SIGLEC1 ELISA Kits)-20 phosphorylation through enhanced eNOS (show NOS3 ELISA Kits) activation and NO production.
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
p21 (CDKN1A)-activated kinase 2
, p21-activated kinase 2
, serine/threonine-protein kinase PAK 2
, p21 activated kinase 2
, S6/H4 kinase
, p21-activated kinase I
, p21-activated protein kinase I