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anti-Human Paxillin antibody for Immunohistochemistry (Formalin-fixed Sections)

Recommended Paxillin Antibody (supplied by: Log in to see )

Antigen
Paxillin (PXN) Antibodies
  • AW108311
  • AW123232
  • CG18061
  • CG18576
  • CG31794
  • CT40481
  • CT42454
  • Dmel\\CG31794
  • dPax
  • Dpax
  • DpaxA
  • DPaxillin
  • DPxn
  • DPxn37
  • LOC100220858
  • pax
  • Pax
  • PDLP
  • PXN
  • wu:fw71f12
Epitope
AA 1-557
60
50
25
24
19
17
13
13
9
8
7
7
7
6
5
5
5
4
4
4
4
4
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
366
163
149
24
5
4
3
3
2
1
1
1
1
1
Host
Mouse
333
47
2
Clonality
Monoclonal
Conjugate
This Paxillin antibody is un-conjugated
7
7
7
5
5
5
5
5
5
5
5
5
2
2
2
1
1
Application
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
291
102
91
56
47
45
25
22
8
8
3
2
2
1
1
1
Supplier
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Catalog No. ABIN967711
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.00086434494 ABIN967712 IHC (f) IF IP WB Mouse IgG1 AA 1-557 Log in to see 349-Paxillin 5
0.00086434494 ABIN1027474 IHC (f) IHC (p) Rabbit IgG AA 356-558 Log in to see Polyclonal
0.00086434494 ABIN1027473 IHC (f) IHC (p) Rabbit IgG AA 356-558 Log in to see Polyclonal

Top referenced anti-Paxillin antibody for Immunohistochemistry (Formalin-fixed Sections)

Similar anti-Paxillin Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Rattus) Chicken Dog (Canine)
Western Blotting (WB) 286 Antibodies 114 Antibodies 102 Antibodies 21 Antibodies 6 Antibodies
Proximity Ligation Assay (PLA) 1 Antibodies
Intracellular Flow Cytometry (ICFC) 1 Antibodies 1 Antibodies
Immunoprecipitation (IP) 23 Antibodies 11 Antibodies 11 Antibodies 12 Antibodies 6 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 47 Antibodies 24 Antibodies 24 Antibodies
Immunohistochemistry (IHC) 102 Antibodies 43 Antibodies 36 Antibodies 7 Antibodies

General

Antigen Paxillin (PXN) Antibodies
Epitope AA 1-557
(60), (50), (25), (24), (19), (17), (13), (13), (9), (8), (7), (7), (7), (6), (5), (5), (5), (4), (4), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(366), (163), (149), (24), (5), (4), (3), (3), (2), (1), (1), (1), (1), (1)
Host Mouse
(333), (47), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This Paxillin antibody is un-conjugated
(7), (7), (7), (5), (5), (5), (5), (5), (5), (5), (5), (5), (2), (2), (2), (1), (1)
Application Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(291), (102), (91), (56), (47), (45), (25), (22), (8), (8), (3), (2), (2), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-Paxillin Antibody

Target Details Paxillin Application Details Handling References for anti-Paxillin Antibody (ABIN967711) Images
Cross-Reactivity Human, Dog (Canine), Mouse (Murine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Chicken Paxillin aa. 1-557
Clone 349-Paxillin
Isotype IgG1

Target Details Paxillin

Product Details anti-Paxillin Antibody Application Details Handling References for anti-Paxillin Antibody (ABIN967711) Images back to top
Antigen
Alternative Name Paxillin (PXN Antibody Abstract)
Background A number of cytoskeletal proteins are tyrosine phosphorylated in Rous sarcoma virus-transformed chick embryo fibroblasts. One of these is the 68 kDa paxillin protein. Paxillin is a cytoskeletal component that localizes to the focal adhesions at the ends of actin stress fibers. It is also present in the focal adhesions of Madin-Darby canine kidney epithelial cells, but is absent from the cell adherens junctions of these cells. Paxillin purified from chicken gizzard migrates as a diffuse band on SDS-PAGE with molecular weight of 65-70 kDa. It binds to the rod domain of vinculin, another focal adhesion protein. It is thought that phosphorylation of paxillin may have a role in that disassembly of focal adhesions and stress fibers during transformation. This antibody is routinely tested by Western blot analysis.
Molecular Weight 68 kDa
Research Area Cancer, Extracellular Matrix
Pathways MAPK Signaling, EGFR Signaling Pathway

Application Details

Product Details anti-Paxillin Antibody Target Details Paxillin Handling References for anti-Paxillin Antibody (ABIN967711) Images back to top
Comment

Related Products: ABIN968533, ABIN967389

Restrictions For Research Use only

Handling

Product Details anti-Paxillin Antibody Target Details Paxillin Application Details References for anti-Paxillin Antibody (ABIN967711) Images back to top
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.

References for anti-Paxillin Antibody (ABIN967711)

Product Details anti-Paxillin Antibody Target Details Paxillin Application Details Handling Images back to top
Product cited in:

Even-Ram, Maoz, Pokroy, Reich, Katz, Gutwein, Altevogt, Bar-Shavit: "Tumor cell invasion is promoted by activation of protease activated receptor-1 in cooperation with the alpha vbeta 5 integrin." in: The Journal of biological chemistry, Vol. 276, Issue 14, pp. 10952-62, 2001

Nikolopoulos, Turner: "Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion." in: The Journal of cell biology, Vol. 151, Issue 7, pp. 1435-48, 2001

van de Water, Houtepen, Huigsloot, Tijdens: "Suppression of chemically induced apoptosis but not necrosis of renal proximal tubular epithelial (LLC-PK1) cells by focal adhesion kinase (FAK). Role of FAK in maintaining focal adhesion organization after acute renal cell injury." in: The Journal of biological chemistry, Vol. 276, Issue 39, pp. 36183-93, 2001

Wine, Chapin: "Adhesion and signaling proteins spatiotemporally associated with spermiation in the rat." in: Journal of andrology, Vol. 20, Issue 2, pp. 198-213, 1999

Background publications

Glenney, Zokas: "Novel tyrosine kinase substrates from Rous sarcoma virus-transformed cells are present in the membrane skeleton." in: The Journal of cell biology, Vol. 108, Issue 6, pp. 2401-8, 1989

Images

Product Details anti-Paxillin Antibody Target Details Paxillin Application Details Handling References for anti-Paxillin Antibody (ABIN967711) back to top
Supplier Images
Western Blotting (WB) image for anti-Paxillin antibody (PXN) (AA 1-557) (ABIN967711) Western blot analysis of Paxillin on a A431 lysate. Lane 1: 1:10,000, lane 2: 1:20,00...
Immunofluorescence (IF) image for anti-Paxillin antibody (PXN) (AA 1-557) (ABIN967711) Immunofluoresence staining of human fibroblasts.