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REVIEW of the functions of paxillin in pathological conditions, particularly in cell migration
This study showed that the PXN plays as an oncogene (show RAB1A ELISA Kits) in glioma progression and suggests a new potential biotarget for therapy
Recruitment of Paxillin, Cdc42 and N-WASP is necessary for cell adhesion, migration and invasion induced by Estradiol in breast cancer cells.
the administration of 10(-6) M retinoic acid (10-20 min) induces the activation of the migration-related proteins Moesin (show MSN ELISA Kits), FAK (show PTK2 ELISA Kits), and Paxillin in T-47D breast cancer cells.
The MBNL3 splicing factor promotes hepatocellular carcinoma by increasing paxillin expression through the alternative splicing of lncRNA-PXN-AS1.
These data suggest that paxillin appears to influence major cell functions in a diverse range of prostate and breast cancer models. The responsiveness of cells to environmental factors such as HGF (show HGF ELISA Kits) or BME may be influenced by paxillin status, although this seems to be dependent on cell type
Knocking out FAK (show PTK2 ELISA Kits) (also known as PTK2 (show PTK2 ELISA Kits)) and vinculin (show VCL ELISA Kits) caused an increase in nuclear paxillin. This could be reversed by rescue with wild-type FAK (show PTK2 ELISA Kits) but not by FAK (show PTK2 ELISA Kits) with a mutated FAT domain, which inhibits paxillin binding.
The role of paxillin in the aging process of skin cells is reviewed.
interactions between Cat-1 (show CRAT ELISA Kits) and its binding partner paxillin are necessary to ensure sufficient Akt (show AKT1 ELISA Kits) activation so that cancer cells are able to grow under anchorage-independent conditions
FAK (show PTK2 ELISA Kits)/SRC (show SRC ELISA Kits) and paxillin play a role in the pathophysiological aspects of mobile tongue squamous cell carcinoma and could constitute therapeutic targets
paxillin may function in adhesion during the morphogenesis of the early zebrafish embryo
Kindlin-2 (show FERMT2 ELISA Kits) is a key protein that couples cell adhesion by activating integrins and the induction of membrane protrusions by activating Rac1 and supplying Rac1 with the Arp2 (show AICDA ELISA Kits)/3 complex.
paxillin and FAK (show PTK2 ELISA Kits) function cell-autonomously to control migrating neuron morphology and speed during cortical development.
paxillin interacts with processed LC3 (show MAP1LC3A ELISA Kits) through a conserved LIR (show CD300C ELISA Kits) motif in the amino-terminal end of paxillin and that this interaction is regulated by oncogenic SRC (show SRC ELISA Kits) activity.
Data show that actomyosin cytoskeletal contractility is required for paxillin localization to developing somite boundaries.
paxillin and Hic-5 (show TGFB1I1 ELISA Kits) have both redundant and distinctive functions in invadosome formation.
Fyn (show FYN ELISA Kits) mediates high glucose-induced actin cytoskeleton remodeling of podocytes via promoting ROCK activation and paxillin phosphorylation
Lithium therapy abrogated GSK3beta overactivity, blunted paxillin hyperphosphorylation, and reinstated actin cytoskeleton integrity in glomeruli associated with an early attenuation of podocyte foot process effacement.
Suggest paxillin up-regulation and phosphorylation as an important mechanism of vascular remodelling underlying pulmonary hypertension.
LPS-induced paxillin phosphorylation at Y31 and Y118 was mediated by c-Abl tyrosine kinase
Study provides evidence that phosphorylation of PXN is required for cisplatin resistance in lung cancer cells.
Data indicate that tramtrack69 regulates ovary epithelial tube morphogenesis through Paxillin, Dynamin (show DNM1 ELISA Kits), and the homeobox protein (show HOXA1 ELISA Kits) Mirror.
New insights from hemichordate genomes: prebilaterian origin and parallel modifications in the paired domain of the Pax gene eyegone
Results identify a link between the focal adhesion protein paxillin and the Atg1 (show ULK1 ELISA Kits) kinase, which has been previously implicated in autophagy.
Data show that Pax genes are involved in the development of the anterior/posterior brain boundary zone during embryonic CNS development in Drosophila.
Paxillin has a role in meiosis and may be a general modulator of mitogen-activated protein kinase (show MAPK1 ELISA Kits) signaling
RING finger protein (show TRIM31 ELISA Kits) XRNF185 (show RNF185 ELISA Kits), which physically binds to paxillin and the proteasome. XRNF185 (show RNF185 ELISA Kits) destabilizes paxillin at focal adhesions and promotes mesodermal cell migration during convergent extension.
Role of Y118 paxillin phosphorylation and stimulated actin polymerization in carotid artery contraction.
This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445).
, Paxillin-derived LIM-only protein
, myocardial ischemic preconditioning associated protein 7