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|Antigen||Peroxisome Proliferator-Activated Receptor gamma (PPARG) Antibodies|
|Epitope||Isoform 1, AA 255-268 Alternatives|
|Reactivity||Dog (Canine), Duck, Guinea Pig, Hamster, Human, Mink, Monkey, Mouse (Murine), Rabbit, Rat (Rattus) Alternatives|
|Conjugate||This PPARG antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA)
|1 reference available|
|Supplier||Log in to see|
Product Details anti-PPARG AntibodyTarget Details PPARG Application Details Handling ProductDetails: References for anti-PPARG antibody (ABIN318834) Images
|Specificity||This antibody detects human peroxisome proliferator-activated receptor gamma (PPARG).|
|Immunogen||Synthetic peptide corresponding to amino acids 255 - 268 of human PPAR gamma isoform 1.|
Target Details PPARGProduct Details anti-PPARG Antibody Application Details Handling ProductDetails: References for anti-PPARG antibody (ABIN318834) Images back to top
|Alternative Name||PPAR-gamma (PPARG Antibody Abstract)|
|Background||PPARG is a member of the nuclear hormone receptor subfamily of transcription factors. Upon activation, PPARG forms heterodimers with retinoid X receptors (RXRs), and functions to regulate transcription of specific gene sequences. PPARG is principally involved in the cellular assimilation of lipids, with key roles in adipocyte differentiation and adipogenesis. Two alternatively spliced isoforms of PPARG exist, termed PPARG1 and PPARG2, which are identical except for an additional 30 amino acids at the N-terminus of PPARG2. This results in a predominant adipocyte localisation for PPARG2, whilst PPARG1 is ubiquitously expressed. PPARG has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer.Synonyms: NR1C3, PPARG, Peroxisome proliferator-activated receptor gamma|
|Pathways||MAPK Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Endopeptidase Activity, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation|
Application DetailsProduct Details anti-PPARG Antibody Target Details PPARG Handling ProductDetails: References for anti-PPARG antibody (ABIN318834) Images back to top
ELISA: 1: 8000 - 1: 32000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-PPARG Antibody Target Details PPARG Application Details ProductDetails: References for anti-PPARG antibody (ABIN318834) Images back to top
|Buffer||Phosphate buffered saline pH 7.2 containing 0.01 % Sodium Azide (NaN3)|
|Precaution of Use||This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
ProductDetails: References for anti-PPARG antibody (ABIN318834)Product Details anti-PPARG Antibody Target Details PPARG Application Details Handling Images back to top
Lazar: "PPAR gamma, 10 years later." in: Biochimie, Vol. 87, Issue 1, pp. 9-13, 2005