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|Application / Reactivity||Human|
|Dot Blot (DB)||20 Antibodies|
|Enzyme Immunoassay (EIA)||7 Antibodies|
|Flow Cytometry (FACS)||1 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||10 Antibodies|
|Immunofluorescence (IF)||34 Antibodies|
|Immunofluorescence (Cultured Cells) (IF (cc))||1 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||43 Antibodies|
|Immunohistochemistry (IHC)||88 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||46 Antibodies|
|Immunoprecipitation (IP)||39 Antibodies|
|Western Blotting (WB)||218 Antibodies|
|Antigen||Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) Antibodies|
|Conjugate||This RPS6KA1 antibody is un-conjugated Alternatives|
Dot Blot (DB), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-RPS6KA1 AntibodyTarget Details RPS6KA1 Application Details Handling References for anti-RPS6KA1 Antibody (ABIN1881765) Images
|Predicted Reactivity||Chicken,Xenopus laevis|
|Purification||This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Immunogen||This RPS6KA1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T359 of human RPS6KA1.|
Target Details RPS6KA1Product Details anti-RPS6KA1 Antibody Application Details Handling References for anti-RPS6KA1 Antibody (ABIN1881765) Images back to top
|Alternative Name||RPS6KA1 (RPS6KA1 Antibody Abstract)|
RPS6KA1 is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation.
Synonyms: RPS6KA1, MAPKAPK1A, RSK1, Ribosomal protein S6 kinase alpha-1, 90 kDa ribosomal protein S6 kinase 1, MAP kinase-activated protein kinase 1a, Ribosomal S6 kinase 1
|NCBI Accession||NP_002944, NP_001006666|
|Pathways||MAPK Signaling, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-RPS6KA1 Antibody Target Details RPS6KA1 Handling References for anti-RPS6KA1 Antibody (ABIN1881765) Images back to top
|Application Notes||WB: 1:2000,DB: 1:500|
|Restrictions||For Research Use only|
HandlingProduct Details anti-RPS6KA1 Antibody Target Details RPS6KA1 Application Details References for anti-RPS6KA1 Antibody (ABIN1881765) Images back to top
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.|
|Precaution of Use||WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.|
References for anti-RPS6KA1 Antibody (ABIN1881765)Product Details anti-RPS6KA1 Antibody Target Details RPS6KA1 Application Details Handling Images back to top
|Product cited in:||
Roux, Ballif, Anjum et al.: "Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 37, pp. 13489-94, 2004 (PubMed).
Fernando, Wimalasena: "Estradiol abrogates apoptosis in breast cancer cells through inactivation of BAD: Ras-dependent nongenomic pathways requiring signaling through ERK and Akt." in: Molecular biology of the cell, Vol. 15, Issue 7, pp. 3266-84, 2004 (PubMed).
Hu, Fang, Dunham et al.: "90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling." in: The Journal of biological chemistry, Vol. 279, Issue 28, pp. 29325-35, 2004 (PubMed).
Bohuslav, Chen, Kwon et al.: "p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1." in: The Journal of biological chemistry, Vol. 279, Issue 25, pp. 26115-25, 2004 (PubMed).
Cavet, Lehoux, Berk: "14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity." in: The Journal of biological chemistry, Vol. 278, Issue 20, pp. 18376-83, 2003 (PubMed).
ImagesProduct Details anti-RPS6KA1 Antibody Target Details RPS6KA1 Application Details Handling References for anti-RPS6KA1 Antibody (ABIN1881765) back to top