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|Antigen||Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) Antibodies|
|Epitope||AA 1-184 Alternatives|
|Reactivity||Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This RPS6KA1 antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-RPS6KA1 AntibodyTarget Details RPS6KA1 Application Details Handling ProductDetails: References for anti-RPS6KA1 antibody (ABIN967837) Images
|Cross-Reactivity||Dog (Canine), Rat (Rattus), Mouse (Murine), Chicken|
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|Immunogen||Human p90[rsk] aa. 1-184|
Target Details RPS6KA1Product Details anti-RPS6KA1 Antibody Application Details Handling ProductDetails: References for anti-RPS6KA1 antibody (ABIN967837) Images back to top
|Alternative Name||Rsk (RPS6KA1 Antibody Abstract)|
|Background||The p90[rsk] (Rsk) and p70[s6k] kinases were first identified based on their ability to phosphorylate the 40S ribosomal protein S6 in vitro. Both of these enzymes are differentially regulated by serine/threonine phosphorylation in response to mitogenic stimulation. ERK1 and ERK2 have been shown to regulate Rsk activity. Once activated by this phosphorylation, a significant amount of Rsk can be found in the nucleus, suggesting that it has a role in nuclear signaling events. The regulation of nuclear Rsk and ERK activities by growth factors is coordinated with the induction of several early response genes. Rsk has also been shown to be activated by ionizing radiation, presumably through an activated MAP kinase. Studies in Xenopus oocytes and mouse NIH/3T3 cells indicate that inactive Rsk and ERK2 exist in a complex of approximately 110kDa. Upon phosphorylation of Rsk and ERK2, the heterodimer dissociates and at least a portion of these activated kinases translocate to the nucleus.|
|Molecular Weight||90 kDa|
|Pathways||MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades|
Application DetailsProduct Details anti-RPS6KA1 Antibody Target Details RPS6KA1 Handling ProductDetails: References for anti-RPS6KA1 antibody (ABIN967837) Images back to top
Related Products: ABIN967389, ABIN968533
|Restrictions||For Research Use only|
HandlingProduct Details anti-RPS6KA1 Antibody Target Details RPS6KA1 Application Details ProductDetails: References for anti-RPS6KA1 antibody (ABIN967837) Images back to top
|Buffer||Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at -20° C.|
ProductDetails: References for anti-RPS6KA1 antibody (ABIN967837)Product Details anti-RPS6KA1 Antibody Target Details RPS6KA1 Application Details Handling Images back to top
|Product cited in:||
Moor, Gan, Karmazyn, Fliegel: "Activation of Na+/H+ exchanger-directed protein kinases in the ischemic and ischemic-reperfused rat myocardium." in: The Journal of biological chemistry, Vol. 276, Issue 19, pp. 16113-22, 2001
Morrione, Navarro, Romano, Dews, Reiss, Valentinis, Belletti, Baserga: "The role of the insulin receptor substrate-1 in the differentiation of rat hippocampal neuronal cells." in: Oncogene, Vol. 20, Issue 35, pp. 4842-52, 2001
Majka, Janowska-Wieczorek, Ratajczak, Kowalska, Vilaire, Pan, Honczarenko, Marquez, Poncz, Ratajczak: "Stromal-derived factor 1 and thrombopoietin regulate distinct aspects of human megakaryopoiesis." in: Blood, Vol. 96, Issue 13, pp. 4142-51, 2000
Hsiao, Chou, Shih, Ferrell: "Evidence that inactive p42 mitogen-activated protein kinase and inactive Rsk exist as a heterodimer in vivo." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 12, pp. 5480-4, 1994
Chung, Pelech, Blenis: "Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 11, pp. 4981-5, 1991
ImagesProduct Details anti-RPS6KA1 Antibody Target Details RPS6KA1 Application Details Handling ProductDetails: References for anti-RPS6KA1 antibody (ABIN967837) back to top