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anti-Human RPS6KA3 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended RPS6KA3 Antibody (supplied by: Log in to see )

Antigen
Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) Antibodies
  • MPK-9
  • Rsk2
  • S6K-alpha3
  • pp90RSK2
  • CLS
  • HU-3
  • ISPK-1
  • MAPKAPK1B
  • MRX19
  • RSK
  • RSK2
  • p90-RSK2
  • ribosomal protein S6 kinase polypeptide 3
  • ribosomal protein S6 kinase, 90kDa, polypeptide 3
  • Rps6ka3
  • RPS6KA3
Epitope
pTyr529
22
15
15
14
13
7
6
4
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
142
64
42
7
7
6
4
4
2
2
2
1
1
1
1
1
1
1
1
1
Host
Rabbit
126
28
Clonality
Polyclonal
Conjugate
This RPS6KA3 antibody is un-conjugated
6
6
6
5
4
4
2
2
2
2
2
2
2
2
2
2
2
Application
Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
99
46
27
26
21
20
18
15
8
8
3
2
2
Options
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Catalog No. ABIN745283
$ 317.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
12.082015 ABIN4351281 ICC IF IHC IHC (p) WB Rabbit IgG Log in to see Polyclonal
1 ABIN392457 IHC (p) WB Rabbit Ig AA 13-42, N-Term Log in to see Polyclonal
1 ABIN2856119 IHC (p) WB Rabbit IgG Center Log in to see Polyclonal
1 ABIN745268 IF (p) IHC (p) WB Rabbit IgG AA 210-260, pSer227 Log in to see Polyclonal
1 ABIN1738951 IHC (p) IP WB Rabbit IgG AA 604-617 Log in to see Polyclonal
1 ABIN700720 IF (p) IHC (p) WB Rabbit IgG AA 80-130 Log in to see Polyclonal
1 ABIN745292 IHC (p) HRP Rabbit IgG pTyr529 Log in to see Polyclonal
1 ABIN1959892 ICC FACS IF IHC (p) ELISA WB Mouse IgG1 Log in to see 4E10
1 ABIN745285 IHC (p) Biotin Rabbit IgG pTyr529 Log in to see Polyclonal
1 ABIN700729 IHC (p) WB HRP Rabbit IgG AA 80-130 Log in to see Polyclonal
1 ABIN700722 IHC (p) WB Biotin Rabbit IgG AA 80-130 Log in to see Polyclonal
1 ABIN1841471 IHC (p) WB Rabbit N-Term Log in to see Polyclonal
1 ABIN713126 IF (p) IHC (p) WB Rabbit IgG pSer369 Log in to see Polyclonal
1 ABIN1932039 IF IHC (p) WB Rabbit IgG AA 1-50 Log in to see Polyclonal
1 ABIN1932040 IF IHC (p) Rabbit IgG AA 1-50 Log in to see Polyclonal
1 ABIN1738952 IHC (p) WB Rabbit IgG C-Term Log in to see Polyclonal

Similar anti-RPS6KA3 Antibodies

Application / Reactivity Mouse (Murine) Human
ELISA 1 Antibodies 46 Antibodies
Flow Cytometry (FACS) 14 Antibodies 21 Antibodies
Immunocytochemistry (ICC) 3 Antibodies 8 Antibodies
Immunofluorescence (IF) 4 Antibodies 15 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 28 Antibodies 28 Antibodies
Immunohistochemistry (IHC) 10 Antibodies 24 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 16 Antibodies
Immunoprecipitation (IP) 8 Antibodies
Western Blotting (WB) 35 Antibodies
Dot Blot (DB) 18 Antibodies
Enzyme Immunoassay (EIA) 3 Antibodies
Immunochromatography (IC) 2 Antibodies

General

Antigen Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) Antibodies
Epitope pTyr529
(22), (15), (15), (14), (13), (7), (6), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine)
(142), (64), (42), (7), (7), (6), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Host Rabbit
(126), (28)
Clonality
Polyclonal
Conjugate This RPS6KA3 antibody is un-conjugated
(6), (6), (6), (5), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(99), (46), (27), (26), (21), (20), (18), (15), (8), (8), (3), (2), (2)
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Product Details anti-RPS6KA3 Antibody

Target Details RPS6KA3 Application Details Handling Images
Specificity This phosphorylation site is homologous in the listed cross reactive species at the specified location.
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human RSK2 around the phosphorylation site of Tyr529
Isotype IgG

Target Details RPS6KA3

Product Details anti-RPS6KA3 Antibody Application Details Handling Images back to top
Antigen
Alternative Name Rsk2 (RPS6KA3 Antibody Abstract)
Background

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4).

Subcellular location: Cytoplasm, Nucleus


Synonyms: CLS, RSK, HU-3, RSK2, MRX19, ISPK-1, p90-RSK2, pp90RSK2, MAPKAPK1B, S6K-alpha3, Ribosomal protein S6 kinase alpha-3, S6K-alpha-3, 90 kDa ribosomal protein S6 kinase 3, p90-RSK 3, p90RSK3, Insulin-stimulated protein kinase 1, MAP kinase-activated protein kinase 1b, MAPK-activated protein kinase 1b, MAPKAP kinase 1b, MAPKAPK-1b, Ribosomal S6 kinase 2, RSK-2, RPS6KA3, ISPK1
Gene ID 6197
UniProt P51812
Research Area Signaling
Pathways MAPK Signaling, Neurotrophin Signaling Pathway

Application Details

Product Details anti-RPS6KA3 Antibody Target Details RPS6KA3 Handling Images back to top
Application Notes FCM(1:20-100), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Restrictions For Research Use only

Handling

Product Details anti-RPS6KA3 Antibody Target Details RPS6KA3 Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-RPS6KA3 Antibody Target Details RPS6KA3 Application Details Handling back to top
Supplier Images
Flow Cytometry (FACS) image for anti-RPS6KA3 antibody (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3) (pTyr529) (ABIN745283) Mouse brain probed with Rabbit Anti-RSK2 (Tyr529) Polyclonal Antibody, Unconjugated (...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-RPS6KA3 antibody (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3) (pTyr529) (ABIN745283) Formalin-fixed and paraffin embedded human kidney labeled with Rabbit Anti-RSK2(Tyr52...