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Browse our RPS6KA3 Proteins (RPS6KA3)

Full name:
Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 Proteins (RPS6KA3)
On are 12 Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) Proteins from 5 different suppliers available. Additionally we are shipping RPS6KA3 Antibodies (139) and many more products for this protein. A total of 160 RPS6KA3 products are currently listed.
CLS, HU-3, ISPK-1, MAPKAPK1B, MPK-9, MRX19, p90-RSK2, pp90RSK2, RSK, RSK2, S6K-alpha3
list all proteins Gene Name GeneID UniProt
RPS6KA3 110651 P18654
RPS6KA3 6197 P51812

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RPS6KA3 Proteins (RPS6KA3) by Origin

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More Proteins for RPS6KA3 Interaction Partners

Mouse (Murine) Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) interaction partners

  1. Downregulation of Rps6ka3 is a promising strategy for the treatment of multiple sclerosis.

  2. Data show that the phosphoinositide-dependent kinase 1 (PDK1 (show PDPK1 Proteins))-p90 (show GPAM Proteins) kDa ribosomal S6 kinases (Rsks) Rsk1 (show RPS6KA1 Proteins)/2 pathway is critical for establishment and maintenance of a normal Langerhans cells (LC) network.

  3. RSK2 regulates craniofacial development including tooth development and patterning via novel transcriptional targets

  4. The results of this study show that RSK2 loss-of-function is associated in the dentate gyrus with multi-level alterations that encompass modifications of glutamate (show GRIN1 Proteins) receptor channel properties, synaptic transmission.

  5. We propose that loss of function mutations in RSK2 that lead to Coffin-Lowry syndrome are related to defects in neuronal growth due to impaired RSK2-dependent PLD1 activity resulting in a reduced vesicle fusion rate and membrane supply.

  6. RSK2 interacted and phosphorylated GSK-3beta at Ser9. Notably, GSK-3beta phosphorylation at Ser9 was suppressed in RSK2(-/-) mouse embryonic fibroblasts.

  7. Pin1 (show PIN1 Proteins) plays a critical role in tumorigenesis plausibly via physical interaction with RSK2 and reciprocal phosphorylation

  8. This study showed that RSK2 signaling contributes to morphine analgesia in the tail withdrawal response.

  9. Results show increased protein levels of Rsk1 (show RPS6KA1 Proteins) and Rsk2 in the striatum of Huntington disease (show HTT Proteins) mice and and striatal cells transfected with full-length mutant Huntingtin (show HTT Proteins).

  10. The study demonistrated that revealed a novel role for RSK2 in cognitive processes and uncovers the critical implication of an intriguing brain structure in place aversion learning.

Human Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) interaction partners

  1. Results indicate that the phosphorylation of EphA2 (show EPHA2 Proteins) at Ser (show SIGLEC1 Proteins)-897 is controlled by RSK (show RPS6KA1 Proteins) and the RSK (show RPS6KA1 Proteins)-EphA2 (show EPHA2 Proteins) axis might contribute to cell motility and promote tumour malignant progression.

  2. miR (show MLXIP Proteins)-191 represses proliferation in primary human fibroblasts via targeting multiple proto-oncogenes, including CDK9 (show CDK9 Proteins), NOTCH2 (show NOTCH2 Proteins), and RPS6KA3.

  3. This is the first report of exon skipping from an exonic mutation of RPS6KA3, demonstrating that a missense mutation and concomitant disruption of normal splicing contribute to the manifestation of CLS

  4. SL0101 and BI-D1870 induce distinct off-target effects in mTORC1-p70S6K (show RPS6KB1 Proteins) signaling, and thus, the functions previously ascribed to RSK1 (show RPS6KA1 Proteins)/2 based on these inhibitors should be reassessed.

  5. Rsk2-mediated inhibition of hyperplasia has now been demonstrated to occur in the arthritic synovium.

  6. Study identifies RSK2 as a new kinase that regulates NHE3 (show SLC9A3 Proteins) activity by direct phosphorylation.

  7. RPS6KA3 in three unrelated Coffin-Lowry syndrome patients including one from the historical Coffin-Lowry syndrome family and found two novel mutations, were analyzed.

  8. Activated RSK2 directly interacts with and phosphorylates FGFR1 (show FGFR1 Proteins), thereby modulating receptor signaling through regulation of endocytosis.

  9. 14-3-3 (show YWHAQ Proteins) binding promotes PDCD4 (show PDCD4 Proteins) degradation, suggesting an important role for RSK (show RPS6KA1 Proteins) in the inactivation of PDCD4 (show PDCD4 Proteins) in melanoma.

  10. Kaposi's sarcoma-associated herpesvirus ORF45 mediates activation of the HIV-1 long terminal repeat via RSK2.

RPS6KA3 Protein Profile

Protein Summary

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).

Alternative names and synonyms associated with RPS6KA3

  • ribosomal protein S6 kinase polypeptide 3 (Rps6ka3)
  • ribosomal protein S6 kinase, 90kDa, polypeptide 3 (RPS6KA3)
  • CLS protein
  • HU-3 protein
  • ISPK-1 protein
  • MAPKAPK1B protein
  • MPK-9 protein
  • MRX19 protein
  • p90-RSK2 protein
  • pp90RSK2 protein
  • RSK protein
  • RSK2 protein
  • S6K-alpha3 protein

Protein level used designations for RPS6KA3

90 kDa ribosomal protein S6 kinase 3 , MAP kinase-activated protein kinase 1b , MAPK-activated protein kinase 1b , MAPKAP kinase 1b , MAPKAPK-1b , RSK-2 , S6K-alpha-3 , p90-RSK 3 , p90RSK3 , ribosomal S6 kinase 2 , ribosomal protein S6 kinase 2 , ribosomal protein S6 kinase alpha-3 , insulin-stimulated protein kinase 1

110651 Mus musculus
6197 Homo sapiens
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