Browse our RPS6KA3 Proteins (RPS6KA3)

Full name:
Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 Proteins (RPS6KA3)
On are 14 Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) Proteins from 6 different suppliers available. Additionally we are shipping RPS6KA3 Antibodies (253) and RPS6KA3 Kits (9) and many more products for this protein. A total of 287 RPS6KA3 products are currently listed.
90kDa, CLS, D17Wsu134e, HU-3, ISPK-1, MAPKAPK1B, MPK-9, MRX19, p90-RSK2, p90rsk, pp90rsk, pp90RSK2, RPS6KA, Rps6ka-rs1, RSK, Rsk2, Rsk3, S6K-alpha3
list all proteins Gene Name GeneID UniProt
RPS6KA3 6197 P51812
RPS6KA3 20112 Q9WUT3

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RPS6KA3 Proteins (RPS6KA3) by Origin

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More Proteins for RPS6KA3 Interaction Partners

Mouse (Murine) Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) interaction partners

  1. The expressions of PDK1, p-PDK1, RSK2 and p-RSK2 were all up-regulated (show PDPK1 Proteins)in collagen-induced arthritis compared with normal. This indicated that P (show PDPK1 Proteins)DK1/RSK2 may participate in inflammatory progress of (show PDPK1 Proteins) RA.

  2. The purified protein can be fully activated in vitro by phosphorylation with protein kinases ERK2 (show MAPK1 Proteins) and PDK1 (show PDPK1 Proteins).

  3. Downregulation of Rps6ka3 is a promising strategy for the treatment of multiple sclerosis.

  4. Data show that the phosphoinositide-dependent kinase 1 (PDK1 (show PDPK1 Proteins))-p90 (show GPAM Proteins) kDa ribosomal S6 kinases (Rsks) Rsk1 (show RPS6KA1 Proteins)/2 pathway is critical for establishment and maintenance of a normal Langerhans cells (LC) network.

  5. RSK2 regulates craniofacial development including tooth development and patterning via novel transcriptional targets

  6. The results of this study show that RSK2 loss-of-function is associated in the dentate gyrus with multi-level alterations that encompass modifications of glutamate (show GRIN1 Proteins) receptor channel properties, synaptic transmission.

  7. We propose that loss of function mutations in RSK2 that lead to Coffin-Lowry syndrome are related to defects in neuronal growth due to impaired RSK2-dependent PLD1 activity resulting in a reduced vesicle fusion rate and membrane supply.

  8. RSK2 interacted and phosphorylated GSK-3beta at Ser9. Notably, GSK-3beta phosphorylation at Ser9 was suppressed in RSK2(-/-) mouse embryonic fibroblasts.

  9. Pin1 (show PIN1 Proteins) plays a critical role in tumorigenesis plausibly via physical interaction with RSK2 and reciprocal phosphorylation

  10. This study showed that RSK2 signaling contributes to morphine analgesia in the tail withdrawal response.

Human Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) interaction partners

  1. Inhibition of RSK2 was used to investigate the function of RSK2 on PDK1 (show PDK1 Proteins)-induced inflammation. The phosphorylation of RSK2 was detected when PDK1 (show PDK1 Proteins) was inhibited. Inhibition of RSK2 reduced the PDK1 (show PDK1 Proteins)-induced cell invasion and cytokines secretion in human rheumatoid arthritis synovial MH7A cells. In response to TNF-alpha (show TNF Proteins), PDK1 (show PDK1 Proteins) could phosphorylate RSK2 and activated RSK2, then promoting the activation of NF-kappaB (show NFKB1 Proteins).

  2. Our finding demonstrates that RSK2 directly phosphorylates stathmin (show STMN1 Proteins) and regulates microtubule polymerization to provide a pro-invasive and pro-metastatic advantage to cancer cells. Therefore, the RSK2-stathmin (show STMN1 Proteins) pathway represents a promising therapeutic target and a prognostic marker for metastatic human cancers.

  3. we discuss the function of the RSK2 signaling axis by interactions with binding partners in cancer development--{REVIEW}

  4. Results showed that RSK2 gene was overexpressed in osteosarcoma patients cells and its knockdown increased cell apoptosis, enhanced cell chemosensitivity, inhibits proliferation and migration, and weakened tumor formation.

  5. Upregulated expression of RSK2 is associated with breast cancer.

  6. Data show that the 90 kDa ribosomal protein S6 (show RPS6 Proteins) kinases RSK1 (show RPS6KA1 Proteins) and RSK2 play a key role in the homing of ovarian cancer cells in metastatic sites by regulating cell adhesion and invasion.

  7. RSK1 (show RPS6KA1 Proteins) and 3 but not RSK2 are down-regulated in breast tumour and are associated with disease progression. RSK (show RPS6KA1 Proteins) may be a key component in the progression and metastasis of breast cancer.

  8. This case is one of the few examples where RPS6KA3 mutations are associated with a non-specific X-linked mental retardation.

  9. Results indicate that the phosphorylation of EphA2 (show EPHA2 Proteins) at Ser (show SIGLEC1 Proteins)-897 is controlled by RSK (show RPS6KA1 Proteins) and the RSK (show RPS6KA1 Proteins)-EphA2 (show EPHA2 Proteins) axis might contribute to cell motility and promote tumour malignant progression.

  10. miR (show MLXIP Proteins)-191 represses proliferation in primary human fibroblasts via targeting multiple proto-oncogenes, including CDK9 (show CDK9 Proteins), NOTCH2 (show NOTCH2 Proteins), and RPS6KA3.

RPS6KA3 Protein Profile

Protein Summary

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).

Alternative names and synonyms associated with RPS6KA3

  • ribosomal protein S6 kinase, 90kDa, polypeptide 3 (RPS6KA3)
  • ribosomal protein S6 kinase, 90kDa, polypeptide 1 (RPS6KA1)
  • ribosomal protein S6 kinase, polypeptide 2 (Rps6ka2)
  • ribosomal protein S6 kinase polypeptide 3 (Rps6ka3)
  • 90kDa protein
  • CLS protein
  • D17Wsu134e protein
  • HU-3 protein
  • ISPK-1 protein
  • MAPKAPK1B protein
  • MPK-9 protein
  • MRX19 protein
  • p90-RSK2 protein
  • p90rsk protein
  • pp90rsk protein
  • pp90RSK2 protein
  • RPS6KA protein
  • Rps6ka-rs1 protein
  • RSK protein
  • Rsk2 protein
  • Rsk3 protein
  • S6K-alpha3 protein

Protein level used designations for RPS6KA3

MAP kinase-activated protein kinase 1b , MAPK-activated protein kinase 1b , MAPKAP kinase 1b , MAPKAPK-1b , RSK-2 , S6K-alpha-3 , insulin-stimulated protein kinase 1 , p90-RSK 3 , ribosomal S6 kinase 2 , ribosomal protein S6 kinase alpha-3 , MAP kinase-activated protein kinase 1 , MAPK-activated protein kinase 1 , MAPKAP kinase 1 , MAPKAPK-1 , S6KII-alpha , p90-RSK , ribosomal protein S6 kinase 2 alpha , ribosomal protein S6 kinase II alpha , 90 kDa ribosomal protein S6 kinase 2 , MAP kinase-activated protein kinase 1c , MAPK-activated protein kinase 1c , MAPKAP kinase 1c , MAPKAPK-1c , RSK-3 , S6K-alpha 2 , S6K-alpha-2 , p90-RSK 2 , p90RSK2 , pp90RSK3 , protein-tyrosine kinase Mpk-9 , ribosomal S6 kinase 3 , ribosomal protein S6 kinase alpha 2 , ribosomal protein S6 kinase alpha-2 , ribosomal protein S6 kinase, 90kD, polypeptide 2 , 90 kDa ribosomal protein S6 kinase 3 , p90RSK3 , ribosomal protein S6 kinase 2

6197 Homo sapiens
386579 Gallus gallus
20112 Mus musculus
110651 Mus musculus
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