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MSK1 Proteins

(Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5))
Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential. Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto- oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro- inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti- inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury.
MSK1 Protein (AA 1-549) (GST tag) MSK1 Protein (AA 1-549) (GST tag) MSK1 Protein (AA 1-549) (GST tag) (ABIN1318830)

RPS6KA5 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA, KAA

MSK1 Protein (AA 372-470) (GST tag) MSK1 Protein (AA 372-470) (GST tag) MSK1 Protein (AA 372-470) (GST tag) (ABIN1318834)

RPS6KA5 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA

MSK1 Protein (AA 271-370) (GST tag) MSK1 Protein (AA 271-370) (GST tag) MSK1 Protein (AA 271-370) (GST tag) (ABIN1318832)

RPS6KA5 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA

MSK1 Proteins by Grade

Find MSK1 Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

MSK1 Proteins by Origin

Find MSK1 Proteins for a variety of species such as anti-Human MSK1, anti-Mouse MSK1. The species listed below are among those available. Click on a link to go to the corresponding products.

MSK1 Proteins by Source

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MSK1 Proteins by Protein Type

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MSK1 Proteins by Application

Find MSK1 Proteins validated for a specific application such as WB, ELISA, AP, AA. Some of the available applications are listed below. Click on a link to go to the corresponding products.

MSK1 Proteins by Biological Activity

Find MSK1 Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular MSK1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (2)
Cat. No. ABIN1318830
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1318834
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1318832
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3093500
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3136336
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN2731176
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN5509024
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7420789
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2731177
Quantity 20 μg
Datasheet Datasheet

Aliases for MSK1 Proteins

ribosomal protein S6 kinase A5 (RPS6KA5) Proteins
ribosomal protein S6 kinase, polypeptide 5 (Rps6ka5) Proteins
ribosomal protein S6 kinase A5 (Rps6ka5) Proteins
3110005L17Rik Proteins
6330404E13Rik Proteins
AI854034 Proteins
MSK1 Proteins
Msk1 Proteins
MSPK1 Proteins
RLPK Proteins
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