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|Application / Reactivity||Monkey||Human|
|Immunohistochemistry (IHC)||2 Antibodies||14 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||1 Antibodies||6 Antibodies|
|Western Blotting (WB)||3 Antibodies||34 Antibodies|
|Dot Blot (DB)||1 Antibodies|
|Flow Cytometry (FACS)||1 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunofluorescence (IF)||2 Antibodies|
|Antigen||Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 6 (RPS6KA6) Antibodies|
|Epitope||AA 15-45, N-Term Alternatives|
|Reactivity||Human, Monkey Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|2 references available|
|Supplier||Log in to see|
Product Details anti-RPS6KA6 AntibodyTarget Details RPS6KA6 Application Details Handling References for anti-RPS6KA6 Antibody (ABIN1882127) Images
|Purification||This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. Purified Rabbit Polyclonal Antibody (Pab)|
|Immunogen||This RSK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-45 amino acids from the N-terminal region of human RSK4.|
Target Details RPS6KA6Product Details anti-RPS6KA6 Antibody Application Details Handling References for anti-RPS6KA6 Antibody (ABIN1882127) Images back to top
|Alternative Name||RSK4 (RPS6KA6 Antibody Abstract)|
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK). The calcium/calmodulin-dependent kinase (CAMK) group consists of 75 kinases regulated by Ca2+/CaM and close relative family (CAMK, CAMKL, DAPK, MAPKAPK).
Synonyms: RPS6KA6, RSK4, Ribosomal protein S6 kinase alpha-6, 90 kDa ribosomal protein S6 kinase 6, Ribosomal S6 kinase 4, pp90RSK4
Application DetailsProduct Details anti-RPS6KA6 Antibody Target Details RPS6KA6 Handling References for anti-RPS6KA6 Antibody (ABIN1882127) Images back to top
|Application Notes||WB: 1:1000,IHC (p): 1:50-100|
|Restrictions||For Research Use only|
HandlingProduct Details anti-RPS6KA6 Antibody Target Details RPS6KA6 Application Details References for anti-RPS6KA6 Antibody (ABIN1882127) Images back to top
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.|
|Precaution of Use||WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.|
References for anti-RPS6KA6 Antibody (ABIN1882127)Product Details anti-RPS6KA6 Antibody Target Details RPS6KA6 Application Details Handling Images back to top
|Product cited in:||
Thakur, Sun, Bollig et al.: "Anti-invasive and antimetastatic activities of ribosomal protein S6 kinase 4 in breast cancer cells." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 14, pp. 4427-36, 2008 (PubMed).
Yntema, van den Helm, Kissing et al.: "A novel ribosomal S6-kinase (RSK4; RPS6KA6) is commonly deleted in patients with complex X-linked mental retardation." in: Genomics, Vol. 62, Issue 3, pp. 332-43, 2000 (PubMed).
ImagesProduct Details anti-RPS6KA6 Antibody Target Details RPS6KA6 Application Details Handling References for anti-RPS6KA6 Antibody (ABIN1882127) back to top